Imperial College London
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DrVerenaZuber

Faculty of Medicine, School of Public Health

Senior Lecturer in Biostatistics
 
 
 
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v.zuber

 
 
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Location

 

526Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Soremekun:2022:10.1016/j.ebiom.2022.103953,
author = {Soremekun, O and Karhunen, V and He, Y and Rajasundaram, S and Liu, B and Gkatzionis, A and Soremekun, C and Udosen, B and Musa, H and Silva, S and Kintu, C and Mayanja, R and Nakabuye, M and Machipisa, T and Mason, A and Vujkovic, M and Zuber, V and Soliman, M and Mugisha, J and Nash, O and Kaleebu, P and Nyirenda, M and Chikowore, T and Nitsch, D and Burgess, S and Gill, D and Fatumo, S},
doi = {10.1016/j.ebiom.2022.103953},
journal = {EBioMedicine},
title = {Lipid traits and type 2 diabetes risk in African ancestry individuals: a Mendelian Randomization study},
url = {http://dx.doi.org/10.1016/j.ebiom.2022.103953},
volume = {78},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Dyslipidaemia is highly prevalent in individuals with type 2 diabetes mellitus (T2DM). Numerous studies have sought to disentangle the causal relationship between dyslipidaemia and T2DM liability. However, conventional observational studies are vulnerable to confounding. Mendelian Randomization (MR) studies (which address this bias) on lipids and T2DM liability have focused on European ancestry individuals, with none to date having been performed in individuals of African ancestry. We therefore sought to use MR to investigate the causal effect of various lipid traits on T2DM liability in African ancestry individuals. METHODS: Using univariable and multivariable two-sample MR, we leveraged summary-level data for lipid traits and T2DM liability from the African Partnership for Chronic Disease Research (APCDR) (N = 13,612, 36.9% men) and from African ancestry individuals in the Million Veteran Program (Ncases = 23,305 and Ncontrols = 30,140, 87.2% men), respectively. Genetic instruments were thus selected from the APCDR after which they were clumped to obtain independent instruments. We used a random-effects inverse variance weighted method in our primary analysis, complementing this with additional sensitivity analyses robust to the presence of pleiotropy. FINDINGS: Increased genetically proxied low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels were associated with increased T2DM liability in African ancestry individuals (odds ratio (OR) [95% confidence interval, P-value] per standard deviation (SD) increase in LDL-C = 1.052 [1.000 to 1.106, P = 0.046] and per SD increase in TC = 1.089 [1.014 to 1.170, P = 0.019]). Conversely, increased genetically proxied high-density lipoprotein cholesterol (HDL-C) was associated with reduced T2DM liability (OR per SD increase in HDL-C = 0.915 [0.843 to 0.993, P = 0.033]). The OR on T2DM per SD increase i
AU  - Soremekun,O
AU  - Karhunen,V
AU  - He,Y
AU  - Rajasundaram,S
AU  - Liu,B
AU  - Gkatzionis,A
AU  - Soremekun,C
AU  - Udosen,B
AU  - Musa,H
AU  - Silva,S
AU  - Kintu,C
AU  - Mayanja,R
AU  - Nakabuye,M
AU  - Machipisa,T
AU  - Mason,A
AU  - Vujkovic,M
AU  - Zuber,V
AU  - Soliman,M
AU  - Mugisha,J
AU  - Nash,O
AU  - Kaleebu,P
AU  - Nyirenda,M
AU  - Chikowore,T
AU  - Nitsch,D
AU  - Burgess,S
AU  - Gill,D
AU  - Fatumo,S
DO  - 10.1016/j.ebiom.2022.103953
PY  - 2022///
SN  - 2352-3964
TI  - Lipid traits and type 2 diabetes risk in African ancestry individuals: a Mendelian Randomization study
T2  - EBioMedicine
UR  - http://dx.doi.org/10.1016/j.ebiom.2022.103953
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35325778
UR  - http://hdl.handle.net/10044/1/96118
VL  - 78
ER  -
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