Imperial College London
Alternate

Walter Distaso

Business School

Professor of Financial Econometrics
 
 
 
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Contact

 

+44 (0)20 7594 3293w.distaso Website

 
 
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Location

 

3.0253 Prince's GateSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alonso:2024:10.1016/j.molmet.2024.101895,
author = {Alonso, AM and Cork, SC and Phuah, P and Hansen, B and Norton, M and Cheng, S and Xu, X and Suba, K and Ma, Y and Dowsett, GK and Tadross, JA and Lam, BY and Yeo, GS and Herzog, H and Bloom, SR and Arnold, M and Distaso, W and Murphy, KG and Salem, V},
doi = {10.1016/j.molmet.2024.101895},
journal = {Molecular Metabolism},
title = {The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake},
url = {http://dx.doi.org/10.1016/j.molmet.2024.101895},
volume = {81},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Peptide YY (PYY3-36) is a post-prandially released gut hormone with potent appetite-reducing activity, the mechanism of action of which is not fully understood. Unravelling how this system physiologically regulates food intake may help unlock its therapeutic potential, whilst minimising unwanted effects. Here we demonstrate that germline and post-natal targeted knockdown of the PYY3-36 preferring receptor (neuropeptide Y (NPY) Y2 receptor (Y2R)) in the afferent vagus nerve is required for the appetite inhibitory effects of physiologically-released PYY3-36, but not peripherally administered pharmacological doses. Post-natal knockdown of the Y2R results in a transient body weight phenotype that is not evident in the germline model. Loss of vagal Y2R signalling also results in altered meal patterning associated with accelerated gastric emptying. These results are important for the design of PYY-based anti-obesity agents.
AU  - Alonso,AM
AU  - Cork,SC
AU  - Phuah,P
AU  - Hansen,B
AU  - Norton,M
AU  - Cheng,S
AU  - Xu,X
AU  - Suba,K
AU  - Ma,Y
AU  - Dowsett,GK
AU  - Tadross,JA
AU  - Lam,BY
AU  - Yeo,GS
AU  - Herzog,H
AU  - Bloom,SR
AU  - Arnold,M
AU  - Distaso,W
AU  - Murphy,KG
AU  - Salem,V
DO  - 10.1016/j.molmet.2024.101895
PY  - 2024///
SN  - 2212-8778
TI  - The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake
T2  - Molecular Metabolism
UR  - http://dx.doi.org/10.1016/j.molmet.2024.101895
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38340808
UR  - http://hdl.handle.net/10044/1/109774
VL  - 81
ER  -
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