Imperial College London
Alternate

DrXavierDidelot

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3622x.didelot

 
 
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Location

 

G30Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Mostowy:2017:10.1101/098335,
author = {Mostowy, RJ and Croucher, NJ and De, Maio N and Chewapreecha, C and Salter, SJ and Turner, P and Aanensen, DM and Bentley, SD and Didelot, X and Fraser, C},
doi = {10.1101/098335},
title = {Frequent recombination of pneumococcal capsule highlights future risks of emergence of novel serotypes},
url = {http://dx.doi.org/10.1101/098335},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Abstract</jats:title><jats:p>Capsular diversity of<jats:italic>Streptococcus pneumoniae</jats:italic>constitutes a major obstacle in eliminating the pneumococcal disease. Such diversity is genetically encoded by almost 100 variants of the capsule polysaccharide locus (<jats:italic>cps</jats:italic>). However, the evolutionary dynamics of the capsule – the target of the currently used vaccines – remains not fully understood. Here, using genetic data from 4,469 bacterial isolates, we found<jats:italic>cps</jats:italic>to be an evolutionary hotspot with elevated substitution and recombination rates. These rates were a consequence of altered selection at this locus, supporting the hypothesis that the capsule has an increased potential to generate novel diversity compared to the rest of the genome. Analysis of twelve serogroups revealed their complex evolutionary history, which was principally driven by recombination with other serogroups and other streptococci. We observed significant variation in recombination rates between different serogroups. This variation could only be partially explained by the lineage-specific recombination rate, the remaining factors being likely driven by serogroup-specific ecology and epidemiology. Finally, we discovered two previously unobserved mosaic serotypes in the densely sampled collection from Mae La, Thailand, here termed 10X and 21X. Our results thus emphasise the strong adaptive potential of the bacterium by its ability to generate novel serotypes by recombination.</jats:p>
AU  - Mostowy,RJ
AU  - Croucher,NJ
AU  - De,Maio N
AU  - Chewapreecha,C
AU  - Salter,SJ
AU  - Turner,P
AU  - Aanensen,DM
AU  - Bentley,SD
AU  - Didelot,X
AU  - Fraser,C
DO  - 10.1101/098335
PY  - 2017///
TI  - Frequent recombination of pneumococcal capsule highlights future risks of emergence of novel serotypes
UR  - http://dx.doi.org/10.1101/098335
ER  -
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