Imperial College London
Alternate

DrXavierDidelot

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 3622x.didelot

 
 
//

Location

 

G30Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Didelot:2016:10.1038/nrmicro.2015.13,
author = {Didelot, X and Walker, AS and Peto, TE and Crook, DW and Wilson, DJ},
doi = {10.1038/nrmicro.2015.13},
journal = {Nature Reviews Microbiology},
pages = {150--162},
title = {Within-host evolution of bacterial pathogens},
url = {http://dx.doi.org/10.1038/nrmicro.2015.13},
volume = {14},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Whole-genome sequencing has opened the way for investigating the dynamics and genomic evolution of bacterial pathogens during the colonization and infection of humans. The application of this technology to the longitudinal study of adaptation in an infected host — in particular, the evolution of drug resistance and host adaptation in patients who are chronically infected with opportunistic pathogens — has revealed remarkable patterns of convergent evolution, suggestive of an inherent repeatability of evolution. In this Review, we describe how these studies have advanced our understanding of the mechanisms and principles of within-host genome evolution, and we consider the consequences of findings such as a potent adaptive potential for pathogenicity. Finally, we discuss the possibility that genomics may be used in the future to predict the clinical progression of bacterial infections and to suggest the best option for treatment.
AU  - Didelot,X
AU  - Walker,AS
AU  - Peto,TE
AU  - Crook,DW
AU  - Wilson,DJ
DO  - 10.1038/nrmicro.2015.13
EP  - 162
PY  - 2016///
SN  - 1740-1526
SP  - 150
TI  - Within-host evolution of bacterial pathogens
T2  - Nature Reviews Microbiology
UR  - http://dx.doi.org/10.1038/nrmicro.2015.13
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000370469800009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60213
VL  - 14
ER  -
Download