Sequence alignment of CTLDs from D melanogaster

Regions of secondary structure are indicated at the top of the alignment: alpha-helices and beta-strands are denoted by H and S respectively. Residues marked 1, 2 or 3 are ligands for Ca2+ ions.  Residues highlighted in green are ligands for Ca2+ ion 1.  Residues highlighted in red are ligands for Ca2+ ion 2.  Cysteine residues are highlighted in yellow.  Residues highlighted in blue are conserved residues in the core of the CTLD fold.  Predicted sugar-binding specificity is indicated at the right-hand side of the alignment. 
 
Abbreviations: RHL-1, rat hepatic lectin 1; CHL, chicken hepatic lectin; MBP-A, rat serum mannose binding protein; MMR CRD-4, human macrophage mannose receptor carbohydrate recognition domain 4; Gal, galactose; GlcNAc, N-acetylglucosamine; Man, mannose; Fuc, fucose.
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Database of CTLD-containing proteins in D melanogaster

 

 

STRUCTURE                   S1--------      H1---------  H2-----------                   S2---- L1------

 

MOTIF                                       F  A   C      A    A O  E  HA                   FAGA 1   1   

 

AGGRECA       VCEEGWNKYQ-G-HCYRHFPDRE------TWVDAERRCREQQSHLSS--IVTPEEQEFVNNNAQ-----------DYQWIGLNDRTIEG--

RHL-1         CCPINWVEYE-G-SCYWFSSSVK------PWTEADKYCQLENAHLVV--VTSWEEQRFVQQHMGP----------LNTWIGLTDQ  NG--

CHL           AQSRQWEYYE-G-RCYYFSLSRM------SWHKAKAECEEMHSHLII--IDSYAKQNFVMFRTRN----------ERFWIGLTDENQEG--

MBP-A         LHAFSMGKKS-GKKFFVTNHERM------PFSKVKALCSELRGTVAI--PRNAEENKAIQEVAK-----------TSAFLGITDEVTEG--

E-SELECTIN       LVLLIKESGAWSFNTSTEAM------TYDEASAYCQQRYTHLVA--IQNKEEIEYLNSILSYSP--------SYYWIGIRKVNN----

MMR-4         KCPEDWGASSRTSLCFKLYAKGK--HEKKTWFESRDFCRALGGDLAS--INNKEYQQTIWRLITSYH--------KLFWIGLTYGSPSE--

PA TC14                         DYEILFSDETMNYADAGTYCQSRGMALVSSAMRDSTMVKAILAFTEVKG--------HDYWVGADNLQDGAY-

                    F                      N        R  G   A                L            

 Q9VIX1*     ALVKAEPFTKI-NDGYYFFGTESL------NWYEAYEKCRELNSELVT--FETDQEFDAVTAFLTANGSR------LTYWTSGNDLAKTG--

Q9VIX0A      LTVDMTPFIKI-NESYYVFGQTKV------NWYVAYENCRRLQSELVT--FETAEEFDAIAAFLNARGDR------SEHWTSGNDLGKTGT-

Q9VIX0B      SLFKYIYNLEI-GEKQYYISLAKT------NWFEASNHCRQNGGFLLN--LESREELELLSPHLHPA---------YSYWLSINDLGERG--

 Q9VQX3      TKVFWPKYERI-GSRLFYINHKDAY-----DWQSAVDFCRDMGGYIAA--IKDQEELDAISARLDD----------KSYWLGINDLQSSN--

 Q9W0I2*     PNKWTMPLLKL-GEKRYYLGIFFKA-----NWFKATQYCRYHGMHLAS--ISSQEENDRLEKHIRDFGLGH-----EHFWISGTDLADEG--

 Q9VYR4*DRCLSPKIGVDTVVTTFSKTCYDFHITKGE-----SFDKAQAICKQTGGDLVH--DFRGATSSYILSELERRKSELKP---QLVWIGAQKEPGITSR

 Q9W3D8      SEIDTTPFVRI-GDNYYYIEPMNKV-----NWFQAAGACRMMNAHLAS--IEDKPEMEALIKYMKAKGFKNN----DYFWISGNDLGTEG-- 

 Q9VQ53      RKIVAPKFELI-GSRFFYIEDETRR-----NWTSAGSACRQMGTQLAT--IRSAEELAALRAKLNKE---------RHYWLDITDLEKEG-- 

 Q9VM07      VSLETPQENDF-VKQRIARNVRY-------IWTSGR-KCNFAGCDRPD--LQPPNENGWFWSGS------------GAKIGPTSQRNTG---

 Q9VGA3      ISTTILFVDASPAFSCYINENTTLTLQVKYIWTSGR-LCDFKGCDRPD--LQPTNINGWFWTAT------------LQKLAPTTERNQG---

 Q9V5B6      GPCGKPYLREL-NGKCFYVGIKKI------NWFGAQNNCLRKGLNLAD--VSTMEDFKAVVHYVTSQVGF------DDFWFGGNDLQSEG-- 

 Q9V5Z6      KLEENEIFQQL-GSKYYYIEKEEKL-----NWHDALDKCHKMGGHLAS--LQSQEELDRFNNQLNGL---------NRYWIDVTNQFNES-- 

 Q9VIY0      TRCRNPYERVR-ENYCYFVADEEP------LHTSFHNFCYQDKRTSRVC-LDSDEEMRVLAHHLANLGYPNG----TQFWSAGHRWPGDN-- 

 Q9V3Q5      NNIKMRRFEKV-GSRHFHIEKNLMQ-----TWFEAYVTCRKMNGHLAN--IQDEMELDGILALAPN----------NSYWIDISKLVENGG- 

 Q9VXX7 ERCPTFRDQPPGALASYNGKCYIFYNRQPL-----NFLDALSFCRSRGGTLIS--ESNPALQGFISWELWRRHRSDVS---SQYWMGAVRDGSDRS- 

 Q9Y102      ALCP-PKFHRV-GTDCYSLVDQRS------SWLEAHFFCKDKNANLTEPGKHADRKLRLFLQKQDALSGEN-----DPIWLGATYDHHNN-- 

 Q9V9L3      QKCN-PLL------QCNAYFSVAGF--AEVNWLEANHVCNRVGAVLAT--VRNEEQHQLMLHYVNRKERIFGN---RTFWLGATNLVDRSY- 

 Q9VPS3      KVSLHPEFEKV-GSRFFYIERHVKQ-----NWFDAMTKCREMGGHLAS--PQNEEELHLISQKLDT----------ESYWLDLSDLTDHG-- 

 Q9VPS2      KTEIPSQFQKI-GWRHFFIEKKHKV-----DWFKATSMCHKMGAHLLT--IQSEDELDAIRTELKDINDGS-----HDFWLDINDIAKWG-- 

 Q9VLD5      HRINPALFQRM-GTRRFYIEKENKQ-----NWFGASNTCRQLGGHIAT--IRDEQEFNEIFSRAPA----------GVFWIDMNAMFKNG-- 

 Q9VQ68      TKIKYLGFEQI-GSKYYYIEKVSEK-----NWSTASKTCRNMGGHLAD--IKDEADLAAIKANLKED---------THYWLGINDLDHEG-- 

 Q9VLM0      NKIKMSVFKKI-GSRHFYLEKQKKM-----PWDSAYDTCRQMGGHLAN--ILDEKELNEIFSEETK----------KKYWVDINSRANDGA- 

 Q9V8E1      TLCP-TNFTQV-ADKCLLVDGSWK------NFYESDRHCRSLNAGLLS--ISNPTEFNVINEWLPIIAPYQ-----PEFWTSGNKLGGTS-- 

 Q9V5B5      PPCP-RRYLRRINGKCYYFSVKKM------NWFGALNNCLRKGLTLAD--LSNQRDFDGAIGFLSGLGNT------EDFWFGGNDLYHEG-- 

 Q9VM16      RKLVLQRYQQI-GSRYFYIEHNLQV-----NWRTAEQRCIEMGGHLAA--FQNAEEYNAIVGQLNK----------ANYWLGVNDLAKQG-- 

 Q9VLW1      KINILHRFKRI-GSRYLHIEDIVQQ-----NWTSALSACQKMGGNLAS--IINEADFNAIVSQLSKD---------NTYMIGISDLAEKG-- 

 Q9VQU4      VQCLQPGFEKI-GDRYFYIEEDVEL-----NWLDAQAKCRRMGGHLAS--IKTKQEFDAIVEKLDDS---------KSYFLGVNENTKTG-- 

 Q9VPS1      TGKPHPEFQKL-GSRYFYIERHVRQ-----NWFDAADKCRRMGGHLAT--PQDEDELYLIRKQLEA----------RWFWLDISNLVDKD-- 

 Q9V827      QRITTIHLDGV-QYFISRMNPYSPEL----NYFLAYQYCRSLGLQLAS--FETKEKAESMTTYLKNAGYGN-----YDFWTSGNRLGTG--- 

 Q9VN14      NFCP-EHYVSF-RQTCYRFIRSPKR-----NWAEAKKICKAHNADLIN--VDNVEKHSFILKNLILQNQRQ-----NRFFISARQTGPL--- 

 Q9V9L2      PQLPAFSPFSL-RDGRFAIGAFAKV-----NWFQAQATCAAYGYTLVS--ITSEQDQRSLRNFLFNYARNQQDLLTDPLWTSGTDLASDN-- 

 Q9VF94      DPCP-ANFTRI-SDNCYYINSQQQV-----NWKTANSACKGLNSHLAE--FEKVSENEEIMAYLLNQPTHRG----RDYWLGGLNPGL---- 

 Q9W468      NVSNTWTMPQE-GLNVFYRFFRDRI-----SWFEADAVCQFHHANLVT--VDNSFQFDATRDLLRELDVN------DIVWIGLMRPQNSD--

 

 

STRUCTU       L2-----       L3------- L4----------    S3--       S4---         S5-----

 

MOTIF       F H   G       H  W      2P2*+ 3      21CA3H+        G W22  C         H C 

 

AGGRECA    DFRWS-DGHP---MQFENWR---PNQPYNFFAA----GEDCVVMIWH----EKGEWNDVPCNY----HLPFTCKK 4 5 Gal

RHL-1      PWKWV-DGTD-YETGFKNWR---PGQPDDWYGHGLGGGEDCAHFT------TDGHWNDDVCRR----PYRWVCET 4 5 Gal

CHL        EWQWV-DGTD-TRSSFTFWK---EGEPNNRGFN-----EDCAHVW------TSGQWNDVYCTY----ECYYVCEK 4 5 GlcNAc

MBP-A      QFMYV-TGGR---LTYSNWK---KDEPNDHGSG-----EDCVTIV------DNGLWNDISCQA----SHTYVCEF 4 5 Man/GlcNAc

E-SELECTIN VWVWV-GTQKPLTEEAKNWA---PGEPNNRQKD-----EDCVEIYIKREK-DVGMWNDERCSK----KKLYLCYT   5 Fuc +

MMR-4      GFTWS-DGSP---VSYENWA---YGEPNNYQNV-----EYCGELKGD----PTMSWNDINCEH----LNNWICQI   5 Man/GlcNAc

PA TC14    NFLWN-DGVS-LPTDSDLWSPNEPSNPQSW--------QLCVQIWSK----YYNLLDDVGCGG----ARRVICEK   5 Gal

                                                                                                  

 Q9VIX1    SHRWFTNAQR---ISSLRWA---RNQPDNAGQ-----KEHCIHLGYIYKDSRKFELNDRPCSQDPNSLFKYICEA 1 5 Gal

Q9VIX0A    HYWFS-NAQL---VTIKRWA---PKQPDNAGG-----REHCIHLGYIYGYSTEFQLNDRPCHNHASSLFKYIYNL 1 5 Gal

Q9VIX0B    VYVSEATGLE---APFLNWS---AGEPDNSSG-----YDRCVELWLST---TSFQMNDLPCYSS----VAFICQL 1 5 Gal?

 Q9VQX3    TYVSVASGRE---VEFLNWN---AGEPNHGNE-----DENCVEL-------IRSKMNDDPCHRK----KHVICQT 2 5 Man/GlcNAc

 Q9W0I2    NFFWMATGRP---ITFTNWN---AGEPNNFRYENGE-EENCLELWNRDG--KGLKWNDSPCSFE----TYFVCEV 4 5 GlcNAc/Man

 Q9VYR4    TWKWV-NGDV---VQKPTWG---KDQPNNYNG-----EQNCVVLDGG----RNWLWNDVGCNLD---YLHFICQH 2 5 ?

 Q9W3D8    AFYWMSNGRP---MTYAPWN-GPKQMPDNYGG-----NENCVHMFA-----TREMINDANCKIQ----MLYVCEA 4 4

 Q9VQ53    DFRISASGKR---PNFLKWR---AGQPNNFSG-----NQHCVDLL------DGLLMYDNKCESL----SYFICQS 3 4

 Q9VM07    DWSST-GGYQ-------------QPQPDNREAAQGN-DESCLSILNNFYN-DGIKWHDVACHHI----KPFVCED 1 4

 Q9VGA3    DWSPT-GGIG-------------LPQPDNREYKQNGAPENCLALLNQFYN-DGVNWHDVACHHK----KSFVCEE 2 4

 Q9V5B6    RFKYISSGKL---VRYMGDS--NIVEPTQRSN-----LDDCLEIRIRP---NVTVVLDVNCQEK----KYFICEQ 4 4

 Q9V5Z6    EFVSVTKGSK---ANFLSWA---DGEPTK--------DGECVDIRTFN---GKTTMNDNSCFAN----LYFICEK 3 4

 Q9VIY0    RFYWNYFGRA-RPLNYSNWA---VDEPTPQM------GRNCLILTLQG---GELIMSSESCYTR----AVDICEQ 3 4

 Q9V3Q5    TFVSTLTGRE---PFFVKWK---SNQDTKK-------KNQCVYI-------YAKEMSYDECFEK----KSFVCQA 2 4

 Q9VXX7    SWKWV-NGDE---LTVSFWS-----HPGG--------DEDCARFDGS----KGWLWSDTNCNTL----LNFICQH 2 3

 Q9Y102    RWQWSMSGRN---LSTDSFSRTDSAQPL---------DNNCAIYDPS----LKYRWSARPCSDK----LRFICQH 2 3

 Q9V9L3    FWTWMSTGIP---VTYAQWS---RREPKSDRTG----QDACLVLG------TDNLWHSEPCQRK----HNFICEN 1 3

 Q9VPS3    QYISLVSGSK---APFLKWN---KGQPNRE-------NAQCVRV-------KGGLYQTFQCDHR----VLFICQA 2 3

 Q9VPS2    EFISLATGMN---PPFLKWH---KHRPQVQI------HQRCVHL-------RGGEMMDGKCSEQ----FLFICQL 1 3

 Q9VLD5    LFASSLTGRS---PPFFKWK---KEERGN--------KFDCVNV-------YNKEMYNENCFNT----HLFICQA 3 3

 Q9VQ68    KFLSMPTGKQ---TTFLKWA---SGRPSQLD------TLNCVFL-------YNGEMYDYPCHYT----FRFICQT 4 3

 Q9VLM0    SWISTLSGRD---VPFLKWK---PNLATNI-------HNHCVYI-------NSNEMYFENCAND----NYFACQA 2 3

 Q9V8E1    DYYWQSTGQK---AVYLPWS---AGQPTTT-------AGDCLTLMANVT**SVHRLTVKPCTQW----APHICQA 2 3

 Q9V5B5    RFQYISNGRL---VRYYSNY--SNVLPLEHSE-----CDDCLEVRIRS---EINMVSADNCHER----QYFICSE 4 2

 Q9VM16    EFISLASGKR---ATYFKWR---KNEPKYNNP-----TQHCAYVFG-----HENIMIVLSCTTD---VMHFICQS 2 2

 Q9VLW1    VFISVSSGKR---APFLKWN---PGEPLYEHV-----DQRCVSI-------HNGGMWVASCTSD----FKYICEA 1 2

 Q9VQU4    DFVSAASGKS---CLYHEWG---PGEPHHNND-----QERCVSI-------LRKLMHVGNCTYE----KRFICQY 1 2

 Q9VPS1    QYISLATGKE---VSYLKWR---HGEPKKSS------TANCAYL-------YAGDYYTYQCSDR----NFFICQA 2 2

 Q9V827    MFLWMSTGLP-FNATFDFFEN**NTSPQRTARDSS***KGCVILKQ-----PTLKWMPEDCSAV----KDFICEQ 0 2

 Q9VN14    NWVNDDNTQL---VQIEDSF-SMDEQPYGDNR----YVRDRVVYAFSK---KRDRWMFMPAYEI--ELNLFICES 2 1

 Q9V9L2    NWVWFSKGRA---VNYRNFQ---NGLPGYSSD-----NRHCLGING-----INGLWVNENCSEL----RYFVCEK 2 1

 Q9VF94    LWIWSNSAKP--VNPNMNLTS**AAEEATGEDVLN***GRCLRLSYNAGK-HSYVYYGQECTSR----HYYICEH 0 1

 Q9W468    RFMWSNSRPL---VADTGYWA--ESLPLMD-------APLCAVIDPI----RDYRWHALRCGGP--ETASFLCEM 0 0

 

 

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This page last updated:
Wednesday, 01 January 2014
Animal lectins home
Contact information: This site is supported by:
 
Kurt Drickamer
Division of Molecular Biosciences
Faculty of Natural Sciences
Imperial College London
 
Email: k.drickamer@imperial.ac.uk