Group V - NK cell receptors

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

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CYTOPLASMIC DOMAIN

 

LDLR                                                               MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWW

Dectin                                                    MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWR

CLEC1                                                 MQAKYSSTRDMLDDDGDTTMSLHSQASATTRHPEPRRTEHRAPSSTWR

CLEC2                                                                  MQDEDGYITLNIKTRKPALVSVGSASSSWWR

CLEC1D                                                        MSEEVNYATLTFQDSAGARNNRDGNNLRKRGHPAPSPIWR

MAFA                                                                  MTDSVIYSMLELPTATQAQNDYGPQQKSSSSR

KLRG2 ...QLLLRAPSQGGTWGRRSPLAAARTESGCDAEGRASPAEGSAGSPGSPTCCRCKELGLEKEDAALLPRAGLDGDEKLPRAVTLTGLPMYVKSLY

CD94                                                                                        MAVFKTTLWR

Ocil                                                             MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWR

HNKRP1                                                     MD-QQAIYAELNLPTDSGPESSSPSSLPRDVCQGSPWHQFALK

KLRF1                                                           MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVTLHWYK

MDL-1                            MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGT

AICL                                                                                           MMTKHKK

CD69                                                            MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQ

CLEC2L   MSHTILLIQTTKRPEGRTYADYESVNECMEGVCKMYEEHVKRMNPNSPSIKYDISQLFDFINDLADLSCLWDWRWDGRWDVEPLSLLLDTTTR

NKG2A                       MDNQGVIYSDLNLPPNPKRQQRKPKGNKSSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVG

NKG2C                       MSKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAE

NKG2E                       MNKQRGTFSEVSLAQDPKPQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAE

NKG2H                       MNKQRGTFSEVSLAQDPKPQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAE

NKG2D                                   MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCREN-------------

DCAL1                              MVSNFFHVIQVFEKSATLISKTEHIGFVIYSWRKSTTHLGSRRKFAISIYLSEVSLQKYDCPFSGTS

CD72    MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLR

 

ITIM     LL     YXXL

 

 

 

TRANSMEMBRANE DOMAIN and NECK REGION

 

LDLR            CLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSA

Dectin           LIAVILGILCLVILVIAVVLGTMGVLSS

CLEC1            PVALTLLTLCLVLLIGLAAWGLLFFQYYQLSNTGQDTISQMEERLGNTSQELQSLQVQNIKLAGSLQHVAEKLCRELYNKA-GAHRCS

CLEC2         VMALILLILYVGMVVGLVALGIWSVMQRNYL-------------------QDENENRTGTLQQLAKRFCQYVVKQSELKGTFKG-HKCS

CLEC1D           HAALGLVTLCLMLLIGLVTLGMMFLQISNDINSDSEKLSQLQKTIQQQQDNLSQQLGNSNNLSMEEEFLKSQISSLLKRQEQMAIKLCQELIIHTSDHRCN

MAFA        PSCSCLVAIALGLLTAVLLSVLL-YQWILCQGSNY--------------------------------------------------STCASCP

KLRG2              YWALA-FMAVLLAVSGVVIVVLASRAGARCQQCPPGWVL

CD94             LISGTLGIICLSLMATLGILLKNSFT-----------------------------------KLSIEPAFTPGPNIELQKDSDCC

Ocil            LFFLIMFLTIIVCGMVAALSAIRA---------------------------------------------------NCHQEPSVCLQA

HNKRP1        LSCAGIILLVLVVTGLSVSVTSLIQKSSIEK-CSVDIQQSRNKTTERPGLL

KLRF1          ILLGISGTVNGILTLTLISLILLVL

AICL                  CFIIVGVLITTNIITLIVKLTRDSQS

CD69         VPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVS

CLEC2L             LLLGAIAVLLFAILVVMSILASKGCIKCEA

NKG2A            ILG-IICLI--LMASVVTIVVIPSTLIQRHNNSSLNTRTQK---------ARHCG

NKG2C            VLG-IICIV--LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARHCG     

NKG2E            VLG-IICIV--LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARPCG

NKG2H            VLG-IICIV--LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARPCG

NKG2D     ASPFFFCCFIAVAMGIRFII---MVAIWSAVFLNS-LFN-------Q-EVQIPLTES--YCG

DCAL1      FVVFSLFLICAMAGDVVY ADIKTVRTSPLELAFPLQRSVSFNFSTVHKS
CD72       YLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQA

                                 DRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADT

 

 

 

CTLD - N-TERMINAL

 

LDLR        PCPQDWIWHGENCYLFSS-GSFNWEKSQEKCLSLDAK---LLKINST-ADLDFIQQAI-SYSS-FPFWMGL

Dectin      PCPPNWIIYEKSCYLFSM-SLNSWDGSKRQCWQLGSN---LLKIDSS-NELGFIVKQV-SSQPDNSFWIGL

CLEC1       PCTEQWKWHGDNCYQFYK-DSKSWEDCKYFCLSENST---MLKINKQ-EDLEFAASQS-YSEFFYSYWTGL

CLEC2       PCDTNWRYYGDSCYGFFR-HNLTWEESKQYCTDMNAT---LLKIDNR-NIVEYIK-----ARTHLIRWVGL

CLEC1B2     PCDANWTYYGDSCYGFFK-HNLTWKESEQYCTDMKAT---LLKTDNQ-NILEYIKA-----RTGLIHWVRL

CLEC1D      PCPKMWQWYQNSCYYFTTNEEKTWANSRKDCIDKNST----LVKIDSLEEKDFLM--SQPLLMFSFFWLGL

MAFA        SCPDRWMKYGNHCYYFSV-EEKDWNSSLEFCLARDSH---LLVITDN-QEMSLLQ----VFLSEAFCWIGL

KLRG2       QCPPGWVLSEEHCYYFSA-EAQAWEASQAFCSAYHAT---LPLLSHT-QD--FLG----RYPVSRHSWVGA

CD94        SCQEKWVGYRCNCYFISS-EQKTWNESRHLCASQKSS---LLQLQNT-DELDFMS------SSQQFYWIGL

Ocil        ACPESWIGFQRKCFYFSD-DTKNWTSSQRFCDSQDAD---LAQVESF-QELNFLL----RYKGPSDHWIGL

HNKRP1      NCPIYWQQLREKCLLFSH-TVNPWNNSLADCSTKESS---LLLIRDK-DELIHTQ--NLIRDKAILFWIGL

KLRF1       -CQSEWLKYQGKCYWFSN-EMKSWSDSYVYCLERKSH---LLIIHDQ-LEMAFIQ---KNLRQLNYVWIGL

MDL-1       VCPKDWEFYQARCFFLST-SESSWNESRDFCKGKGST---LAIVNTP-EKLKFLQ----DITDAEKYFIGL

AICL        LCPYDWIGFQNKCYYFSK-EEGDWNSSKYNCSTQHAD---LTIIDNI-EEMNFLR----RYKCSSDHWIGL

CD69        SCSEDWVGYQRKCYFIST-VKRSWTSAQNACSEHGAT---LAVIDSE-KDMNFLK----RYAGREEHWVGL

CLEC2L      PCPEDWLLYGRKCYFFSE-EPRDWNTGRQYCHTHEAV---LAVIQSQ-KELEFMF----KFTRR-EPWIGL

NKG2A       HCPEEWITYSNSCYYIGK-ERRTWEESLLACTSKNSS---LLSIDNE-EEMKFLS----IISP--SSWIGV

NKG2C       HCPEEWITYSNSCYYIGK-ERRTWEESLLACTSKNSS---LLSIDNE-EEIKFLA----SILP--SSWIGV

NKG2D       PCPKNWICYKNNCYQFFD-ESKNWYESQASCMSQNAS---LLKVYSK-EDQDLLK----LVKS--YHWMGL

NKG2E       HCPEEWITYSNSCYYIGK-ERRTWEESLQACASKNSSS--LLSIDNE-EEMKFLA----SILP--SSWIGV

NKG2H       HCPEEWITYSNSCYYIGK-ERRTWEESLQACASKNSSS--LLSIDNE-EEMKFLA----SILP--SSWIGV

DCAL1       CPAKDWKVHKGKCYWIAE-TKKSWNKSQNDCAINNSYLMVIQDITAMVRFNI

CD72        CCPSGWIMHQKSCFYISL-TSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGL

  

 

CTLD - C-TERMINAL

 

LDLR         SRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGA----VYAENCILAAFSICQKKANLRAQ

Dectin       SRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSV----IYDQLCSVPSYSICEKKFSM

CLEC1        LRPDSGKAWLWMDGTPFTSELFHIIIDVT-SPRSRDCVAILNGM----IFSKDCKELKRCVCERRAGMVKPESLHVPPETLGEGD

CLEC2        SRQKSNEVWKWEDGSVISENMFEFLED---GKGNMNCAYFHNGK----MHPTFCENKHYLMCERKAGMTKVDQLP

CLEC1B2      SHQNSNEVFFEGIYSTFPIHRFGLSED---GKGNMNCAYFHNQK----RHSTFCENKHYLMCERKAGMAKVDQLP

CLEC1D       SWDSSGRSWFWEDGSVPSPSLFSTKELDQING-SKGCAYFQKGN----IYISRCSAEIFWICEKTAAPVKTEDLD

MAFA         RNNS---GWRWEDGSPLNFSRISS------NSFVQTCGAINKNG----LQASSCEVPLHWVCKKVRL

KLRG2        WRGP--QGWHWIDEAPLPPQLLPEDG---EDNLDINCGALEEGT----LVAANCSTPRPWVCAKGTQ

CD94         SYSEEHTAWLWENGSALSQYLFPSFE----TFNTKNCIAYNPNGN---ALDESCEDKNRYICKQQLI

Ocil         SREQ-GQPWKWINGTEWTRQFPIL--------GAGECAYLNDKG----ASSARHYTERKWICSKSDIHV

HNKRP1       NFSLSEKNWKWINGSFLNSNDLEIRG----DAKENSCISISQTS----VYSEYCSTEIRWICQKELTPVRNKVYPDS

KLRF1        NFTSLKMTWTWVDGSPIDSKIFFIKG----PAKENSCAAIKESK----IFSETCSSVFKWICQY

MDL-1        IYHREEKRWRWINNSVFNGNVTNQ-------NQNFNCATIGLTKT---FDAASCDISYRRICEKNAK

AICL         KMAK-NRTGQWVDGATFTKSFGMR--------GSEGCAYLSDDG----AATARCYTERKWICRKRIH

CD69         KKEP-GHPWKWSNGKEFNNWFNVT--------GSDKCVFLKNTE----VSSMECEKNLYWICNKPYK

CLEC2L       RRVG--DEFHWVNGDPFDPDTFTI-------AGPGECVFVEPTR----LVSTECLMTRPWVCSKMAYT

NKG2A        FRNSSHHPWVTMNGLAFKHEIKDS------DNAELNCAVLQVNR----LKSAQCGSSIIYHCKHKL

NKG2C        FRNSSHHPWVTINGLAFKHKIKDS------DNAELNCAVLQVNR----LKSAQCGSSMIYHCKHKL

NKG2D        VHIPTNGSWQWEDGSILSPNLLTII-----EMQKGDCALYASSFK---GYIENCSTPNTYICMQRTV

NKG2E        FRNSSHHPWVTINGLAFKHEIKDS------DHAERNCAMLHVRG----LISDQCGSSRIIRRGFIMLTRLVLNS

NKG2H        FRNSSHHPWVTINGLAFKHEIKDS------DHAERNCAMLHVRG----LISDQCGSSRIIVSISFRIKALELAVHQIKFYICSNRNDIMIA

CD72         SSNK---DWKLTDDTQRTRTYAQS----------SKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD

              

CONSERVED RESIDUES

 

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This page last updated:	Wednesday, 01 January 2014	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk