Group X - Polycystin family

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

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N-TERMINAL REGION inc. SIGNAL SEQUENCE

 

Human PKD1            MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRV

 

Human PK1L2           MSAVGLVLLVLALRLRATTVKPEEGSFCSNSQVAFRDACYEFVPLGRTF

Human PK1L3           MFFKGGSWLWLYIRTSIILGSELNSPAPHGQNNCYQLNRFQCSFEEAQHYCHVQRGFLAH 

 

 

SIGNAL SEQUENCE

 

 

 

 

LEUCINE-RICH REGION

 

Human PKD1          NCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSG

 

Human PKD1          NPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGC

 

LEUCINE-RICH REPEATS

 

WSC DOMAIN and LINKER

 

Human PKD1  WSC     GEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQP

 

Human PKD1  Link    SSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPH

 

 

 

PKD REPEAT

 

Human PKD1         GPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVE

Human PKD1         AAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHP

 

CONSERVED RESIDUES

 

 

CTLD

 

Human PKD1        LCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRCLDVWIGFSTVQGVE

Human PK1L2       FC-SNSQVAF-RDACYEFVPLGRTFRDAQSWCEGQGGHLVFIQD-EGTQWFLQKHISQDREWWIGLTWNLARN

Human PK1L3       GSELNSPAPHGQNNCYQLNRFQCSFEEAQHYCHVQRGFLAHIWNKEVQDLIRDYLEEGKK-WWIGQNVMPLKK

 

Human PKD1       -VGPAPQGEAFSLESCQNWLPGEPHPATAEHC---VRLGPTG-WCNTDLCSAPHSYVCE

Human PK1L2      GTTEGPGTWLDTSNVTYSNWHGGQAAAAPDTCGHIGR-GPSSEWVTSD-CAQTFAFMCE

Human PK1L3      -----------HQDNKYPADVAANGPPKPLSCTYLSR-NFIRISSKGDKCLLKYYFICQ

 

CONSERVED CORE RESIDUES

 

LINKER

 

Human PKD1      LQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNR

 

                TQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGH

 

                PGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLY

 

                VPTNGSALVLQVDSGANATATARWPG

 

 

LDL-RECEPTOR CLASS A ATYPICAL

 

PKD REPEATS

 

Human PKD1  (2)     GSVSARFENVCPALVATFVPGCPWETNDTLFSV--------------------------VALPWLSEGEHVVDVVVENSASRANLSLRVTAE EPICGLRATPSPEA

Human PKD1  (3)     RVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVV---------------------FNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVE RMNRMQGLQVSTVPAVL

Human PKD1  (4)     SPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVR ASLPSVAVGVSDGV

Human PKD1  (5)     LVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPA--------------------ANHTYASRGTYHVRLEVNNTVSGAAAQADVRVF EELRGLSVDM

Human PKD1  (6)     SLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEAT-------------------VEHVYLRAQNCTVTVGAASPAGHLARSLHVLVF VLEVLRVEPAAC

Human PKD1  (7)     IPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPT-------------------VTHNFTRSGTFPLALVLSSRVNRAHYFTSICVE PEVGNVTLQPERQ

Human PKD1  (8)     FVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPE-------------------VTFIYRDPGSYLVTVTASNNISAANDSALVEVQ EPVLVTSIKVNGS

Human PKD1  (9)     LGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPE-----------------------VTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVK RRVRGLVVNASRT

Human PKD1 (10)     VVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPT---------------------ISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVL QLIEGLQVVGGGR--

Human PKD1 (11)     YFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKG-------------------FSLTVLEAGTYHVQLRATNMLGSAWADCTMDFV EPVGWLMVAASPN

Human PKD1 (12)     PAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPF---------------------TTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQ VPVSGLSIRASEPG

Human PKD1 (13)     GSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPH---------------------VTMVFPDAGTFSIRLNASNAVSWVSATYNLTAE EPIVGLVLWASSK

Human PKD1 (14)     VVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPR---------------------FSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVL EAVSGLQVPNCCEP

Human PKD1 (15)     GIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRD----------------VTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQ DAVQYVALQSGP

Human PKD1 (16)     CFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPR--------------------AEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQ VLA

 

 

CONSERVED RESIDUES

 

REJ DOMAIN

 

Human PKD1               CREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANV

                         TVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATN

                         QTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEE

                         EGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGA

                         AVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIA

                         AALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVL

                         NEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNP

    

 

 

 

 

     Human PK1L2         RHRLEIQATGNTTTSTISRNITVHLVELLSGLQASWASDHLELGQDLLITISLAQGTPEELTFEVAGLNATFSHEQVSFGEPFGICRLAVPVEGTFLVTMLVR

                         NAFSNLSLEIGNITITAPSGLQEPSGMNAEGKSKDKGDMEVYIQPGPYVDPFTTVTLGWPDNDKELRFQWSCGSCWALWSSCVERQLLRTDQRELVVPASCLP

                         PPDSAVTLRLAVLRGQELENRAEQCLYVSAPWELRPRVSCERNCRPVNASKDILLRVTMGEDSPVAMFSWYLDNTPTEQAEPLLDACRLRGFWPRSLTLLQSN

                         TSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREVPACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGE

                         ENNDFVLTVVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSLS

                         AVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQWEASLALQHASEALLTVSAKARPEDQRRQAATRDLFQAVGSVLEASLSNRPEEPAEASSSQIATVLRLL

                         RVMEHVQTTLLLGKLPGGLPAMLATPSISVYTNRIQPWSWQGSSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSP

 

 

 

LINKER

 

     Human PKD1          FPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEE

 

                    PEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGL

 

 

GPS DOMAIN

 

Human PKD1        YTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPS-

Human PK1L2       -LSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGSTFLVMSNA

Human PK1L3       -VTQCYYWEIHNQTWSSAGCQVGPQSTILRTQCLCNHLTFFASDFFVVPRT

 

 

MEMBRANE-SPANNING DOMAIN and CYTOPLASMIC TAIL

 

Human PKD1        RWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPP

Human PK1L2       ---------------------------------GPRTSPYQTHCLCNHLTFFGSTFLVMS

Human PK1L3       -----------------------------------------TQCLCNHLTFFASDFFVVP

 

Human PKD1        SHVRFVFPEP---TADVNYIVMLTCAVCLVTYMVM-AAILHKLDQLDASRGRA--IPFCG

Human PK1L2       NAINIHQTAELFATFEDN-PVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVLEDND

Human PK1L3       RTVNVEDTIKLFLRVTNN-PVGVSLLASLLGFYVITVVWARKKDQADMQKVKVTVLADND

 

Human PKD1        QRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDG--DRAFHRNSLDIFRIA

Human PK1L2       PFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLS

Human PK1L3       PSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLT

 

Human PKD1        TPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVE

Human PK1L2       TLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVG--DCVLD

Human PK1L3       TWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLG--DCELD

 

Human PKD1        KEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLF

Human PK1L2       KVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLLCT

Human PK1L3       RVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQFTRVQRLSCCMTLLLCN

 

Human PKD1        LGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKV

Human PK1L2       MLTSIMFWGVPKDPAEQKMDLG-KIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPRV

Human PK1L3       MVINVMFWKINSTTAKRDEQMR-PFAVAWSELLVSIHTAVILFPINLVIGRLFPLIEPQE

 

Human PKD1        AGSPS--------------PTPAGQQVLDIDSCLDSSVLDSSFLTF-S----GLHAEQAF

Human PK1L2       AKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFK------ALKVPSPA

Human PK1L3       TLPLFPPIQASC--LSDASVEPLSATMV-----VEELKETVRFLLRRNTYLLSKCEQPPW

 

Human PKD1        VG-------QMKSDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQA---

Human PK1L2       LGWDSVNLMDINSLLALVEDVIYPQN--TSGQVFWEEAKKREDPVTLTLGSSEMKEKSQC

Human PK1L3       SSWDITKLVKLLSSLVSSHLEGQGCH--QQGERHWARVVP--------------------

 

Human PKD1        ----GHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLS

Human PK1L2       PKPKAARSGPWKDSAYRQCLYLQLE----HVEQELRLVGPRGFSQPHS------HAQAL-

Human PK1L3       ------------ENHHHFCCYLHRV----L-QRLKSHLGTLGLTQGHQ------SCDFLD

 

Human PKD1        SLSSTPGEKTETLALQRL-GELGPPSPGLNWEQPQAAR---LSRTGLVEGLRKRLLPAWC

Human PK1L2       ------------RQLQTLKGGLG--VQPGTWAPAH--------ASALQVSKPPQGLPWWC

Human PK1L3       AA----------SQLQKLQELLETHILPTEQEPSREVTSFAILSSEEGKKPISNGLSKWL

 

Human PKD1        ASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALY

Human PK1L2       ILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAVSFVESMFVTQPLKVLGFAAF

Human PK1L3       TSVCWLLLGFTSLASAFFTALYSLELSKDQATSWMISIILSVLQNIFISQPVKVVFFTFL

 

Human PKD1        FSLVAKRLHPDEDDTLVESPAVT-PV---S--------ARVPRVRPPHGFALFLAKEEAR

Human PK1L2       FALVLKRVDDEEDTVAPLPGHLLGP--DPYALFRARRNSSRDVYQPPLTAAIEKMKTTHL

Human PK1L3       YSLMMSRMPRLNKENEQQTKRILALLAKCSSSVPGSRDKNNPVYVAPAINSPTKHPERTL

 

Human PKD1        KVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEE

Human PK1L2       KEQKAFALIREILAYLGFLWMLLLVAYGQRDP--SAYHLNRHLQ-HSFTRGFSGVLGFRE

Human PK1L3       KKKKLFKLTGDILVQILFLTLLMTAIYSAKNS--NRFYLHQAIW-KTFSHQFSEIKLLQD

 

Human PKD1        LWPWMAHVLLPYVHGNQS-------SPELGPPRLRQVRLQEALYPDPPGPR--VHTCS--

Human PK1L2       FFKWANTTLVSNLYGHPPGFITDGNSKLVGSAQIRQVRVQESSCPLAQQPQAYLNGCRAP

Human PK1L3       FYPWANHILLPSLYGDYRGKNAVL---------------EPSHCKCGVQLIFQIPRTKTY

 

Human PKD1        -AAGGFSTSDYDVGWESPHNGSGTWAYSAPD-LLGAWSWGSCAVYDSGGYVQELGLSLEE

Human PK1L2       YSLDAEDMADYGEGWNATT--LSEWQYQSQDQRQGYPIWGKLTVYRGGGYVVPLGTDRQK

Human PK1L3       EKVDEGQLAFCDNG-----------------HTCGRPK----SLFP------------GL

 

Human PKD1        SRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFA

Human PK1L2       HVKILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIVTLTLETSALGTFFTHAALQSLR

Human PK1L3       HLRRFSYICSPRPMVLIPTDELH-ERLTSKNENG-------FSYIMRGAFFTSLRLESFT

 

Human PKD1        LRRLSAGLSLP-LLTSVCLLLFAVHFAVAEAR-----TWH-REGRWRVLRLGA-WARWLL

Human PK1L2       LYPFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKETWGYFCSKWNLLELAIILASWSA

Human PK1L3       SLQMSKKGCVWSIISQVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFIL

 

Human PKD1        VALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVK

Human PK1L2       LAVFVKRA-------VLAERDLQRC-RNHREEGISFSETAAADAALGYIIAFLVLLSTVK

Human PK1L3       LGLDMKSI-------SLHKKNMARY-RDDQDRFISFYEAVKVNSAATHLVGFPVLLATVQ

 

Human PKD1        AAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVD---SLWSV

Human PK1L2       LWHLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLIFGWKLRSYKTLFDA

Human PK1L3       LWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSS

 

Human PKD1        AQALLVLCPGTGLSTLCPAESWHLSPLLCVGL-------WALRLWGALRLGAVILRWRYH

Human PK1L2       AETMVSLQ----LGIFNYEEVLDYSPVLGSFLIGSCIVFMTFVVL-NLFISVILVAF---

Human PK1L3       AVTVVGLL----MGISHQEEVFALDPVLGTFLILTSVILMVLVVI-NLFVSAILMAF---

 

Human PKD1        ALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRG--S

Human PK1L2       ---SEEQKYYQLSEEGEIVDLLLMKILSFLGIKSKREEPGSSRE-----QPGSLSQTRHS

Human PK1L3       ---GKERKS--LKKEAALIDTLLQKLSNLLGISWPQKTSSEQAA--------TTAVGSDT

 

Human PKD1        KVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRL

Human PK1L2       RPAQALPKD---------------------------------------------------

Human PK1L3       EVLDELP-----------------------------------------------------

 

Human PKD1        NQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSR

Human PK1L2       ------------------------------------------------------------

Human PK1L3       ------------------------------------------------------------

                                                                              

 

 Human PKD1        TPLRAKNKVHPSST

 Human PK1L2       --------------

 Human PK1L3       --------------

 

PREDICTED TRANSMEMBRANE REGIONS

 

PLAT DOMAIN

 

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This page last updated:	Wednesday, 01 January 2014	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk