Jane Lin

Single Molecule Detection (SMD), which enables measurement of structural and chemical variance of apparently identical single molecules, has been one of the ultimate goals in chemical analysis. With the spatial dimension decreased to that of individual molecules, nanopores and nanopipettes have the capability to analyze charged targets at single-molecule level. I intend to modify aptamers on the surface of nanopipette for single molecule detection of proteins, which might give insight into the interaction between aptamers and target proteins.

Mini-bio

  • PhD in Chemistry (Currently); Department of Chemistry, Imperial College London, Supervisor: Dr. Joshua Edel
  • MSc in Analytical Chemistry (2011-2014); Department of Chemistry, Xiamen University, China. Supervisor: Prof. Chaoyong James Yang
  • BSc in Chemistry (2007-2011); Department of Chemistry, Xiamen University, China.

Publications

  1. Lin, X.; Zhang, C.; Huang, Y.; Zhu, Z.; Chen, X.; Yang, C.*, Backbone Modified Molecular Beacon for Highly Sensitive and Selective Detection of MicroRNA Based on Duplex Specific Nuclease Signal Amplification, Chem. Commun. , 2013, 49, 7243.
  2. Lin, X.; Cui, L.; Huang, Y.; Lin, Y.; Xie, Y.; Zhu, Z.; Yang, C.*, Carbon Nanoparticle-Protected Aptamer Probes for Highly Sensitive and Selective Detection of Biomolecules Based On Nuclease-Assisted Signal Amplification Chem. Commun. , 2014,50, 7646
  3. Cui, L.; Lin, X.; Lin, N.; Song, Y.; Zhu, Z.; Chen, X.; Yang, C.*,Graphene Oxide -Protected DNA Probes for Multiplex MicroRNA Analysis in Complex Biological Samples Based on Cyclic Enzymatic Amplification Method, Chem. Commun. , 2012, 48, 194. (Inside Cover)
  4. Cui, L.; Ke, G.; Lin, X.; Song, Y.; Zhang, H.; Guan, Z.; Zhu, Z.; Yang, C.*, Cyclic Enzymatic Amplification Method (CEAM) Based on Exonuclease III for Highly Sensitive Bioanalysis, Methods, 2013, 63, 202
  5. Cui, L.; Chen, Z.; Zhu, Z.; Lin, X.; Chen, X.; Yang, C.*, Stabilization of ssRNA on Graphene Oxide Surface: An Effective Way to Design Highly Robust RNA Probes, Anal. Chem., 2013, 85, 2269