Dr Asad Jamal

This webinar will be held on zoom. The structure of the event will be a presentation followed by audience Q&A. Please register to be sent the joining instructions. You can pre-submit questions for the Q&A section when registering.

This webinar is part of the series

Molecular Level Understanding is Crucial for Targeted Drug Delivery in the Brain

The theme discussed in this webinar will be:

Biomechanical and biochemical aspects of infusion-based targeted drug delivery in brain


Glioblastoma multiforme (GBM), a grade IV glioma, is the most aggressive and frequently diagnosed form of primary central nervous system (CNS) tumour in adults, with an average age of 64. The GBM leads to 250,000 deaths per year worldwide and have poor prognosis due to their location and fast development.

The conventional therapies suffer from limitations e.g., passing drugs through the blood-brain barrier (BBB), unwanted drugs distribution throughout the tissue due to passive diffusion and poor delivery to the target or are not viable because of severe side effects e.g., localised tissue damage.

The infusion-based targeted drug delivery by robotically steerable needles provides an opportunity to overcome these challenges. Advances have been made; however, ultimate success in the clinical applications remains a challenge due to poor understanding of drug flow and distribution behaviour in complex brain tissue.

The focus of this webinar is biomechanics of infusion-based drug delivery and importance of molecular level processes that influence the flow and distribution mechanisms in complex brain tissue.


Dr. Asad Jamal

Faculty of Engineering, Department of Mechanical Engineering, Research Associate

Dr Asad Jamal is in the Tribology Group, Department of Mechanical Engineering, Imperial College London. He is interested in experimental research on biomechanics and drug delivery in soft tissues. He is collaborating with colleagues from Department of Bioengineering and investigating the consequences of molecular processes on the mechanisms of infusion-based drug delivery. His seminal work on biomechanical aspects of infusion mechanisms in brain white matter tissue has been previously featured on Imperial’s main page and selected as featured article by IEEE TBME.

Other webinars in the Molecular Level Understanding is Crucial for Targeted Drug Delivery in the Brain series

About The Institute for Molecular Science and Engineering

The Institute for Molecular Science and Engineering (IMSE) is one of Imperial College London’s Global Institutes, drawing on the strength of its four faculties to address some of the grand challenges facing the world today. The Institute’s activities are focused on tackling problems where molecular innovation plays an important role.

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