Pain Medicine
Persistent pain results in suffering and poor quality of life. In addition, the lack of proper control of persistent pain may lead to the development of physical and mental disabilities, which further devastate the patient’s quality of life. The main goal of our research activities is to identify pivotal mechanisms in neuronal processing of information induced by various persistent painful conditions, which could be used to develop new pain killers. Hence, our activities will ultimately improve patients’ quality of life.
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Journal articleSantha P, Jenes A, Somogyi C, et al., 2010,
The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons
, ACTA PHYSIOLOGICA HUNGARICA, Vol: 97, Pages: 149-158, ISSN: 0231-424X- Author Web Link
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- Citations: 25
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Journal articleLever IJ, Robinson M, Cibelli M, et al., 2009,
Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury
, J.Neurosci., Vol: 29, Pages: 3766-3780Fatty acid amide hydrolase (FAAH) is a degradative enzyme for a group of endogenous signaling lipids that includes anandamide (AEA). AEA acts as an endocannabinoid and an endovanilloid by activating cannabinoid and vanilloid type 1 transient receptor potential (TRPV1) receptors, respectively, on dorsal root ganglion (DRG) sensory neurons. Inhibition of FAAH activity increases AEA concentrations in nervous tissue and reduces sensory hypersensitivity in animal pain models. Using immunohistochemistry, Western blotting, and reverse transcription-PCR, we demonstrate the location of the FAAH in adult rat DRG, sciatic nerve, and spinal cord. In naive rats, FAAH immunoreactivity localized to the soma of 32.7 {+/-} 0.8% of neurons in L4 and L5 DRG. These were small-sized (mean soma area, 395.96 {+/-} 5.6 {micro}m2) and predominantly colabeled with peripherin and isolectin B4 markers of unmyelinated C-fiber neurons; 68% colabeled with antibodies to TRPV1 (marker of nociceptive DRG neurons), and <2% colabeled with NF200 (marker of large myelinated neurons). FAAH-IR was also present in small, NF200-negative cultured rat DRG neurons. Incubation of these cultures with the FAAH inhibitor URB597 increased AEA-evoked cobalt uptake in a capsazepine-sensitive manner. After sciatic nerve axotomy, there was a rightward shift in the cell-size distribution of FAAH-immunoreactive (IR) DRG neurons ipsilateral to injury: FAAH immunoreactivity was detected in larger-sized cells that colabeled with NF200. An ipsilateral versus contralateral increase in both the size and proportion of FAAH-IR DRG occurred after spinal nerve transection injury but not after chronic inflammation of the rat hindpaw 2 d after injection of complete Freund's adjuvant. This study reveals the location of FAAH in neural tissue involved in peripheral nociceptive transmission
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Journal articleBaiou D, Santha P, Avelino A, et al., 2007,
Neurochemical characterization of insulin receptor-expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice
, JOURNAL OF COMPARATIVE NEUROLOGY, Vol: 503, Pages: 334-347, ISSN: 0021-9967- Author Web Link
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- Citations: 34
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Journal articleDinis P, Charrua A, Avelino A, et al., 2005,
The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate
, EUROPEAN UROLOGY, Vol: 48, Pages: 162-167, ISSN: 0302-2838- Author Web Link
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- Citations: 43
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Journal articleTahim AS, Sántha P, Nagy I, 2005,
Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons
, NEUROSCIENCE, Vol: 136, Pages: 539-548, ISSN: 0306-4522- Author Web Link
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- Citations: 67
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Journal articleDinis P, Charrua A, Avelino A, et al., 2004,
Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis
, JOURNAL OF NEUROSCIENCE, Vol: 24, Pages: 11253-11263, ISSN: 0270-6474- Author Web Link
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- Citations: 154
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Journal articleNagy I, Sántha P, Jancsó G, et al., 2004,
The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology
, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 500, Pages: 351-369, ISSN: 0014-2999- Author Web Link
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- Citations: 219
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Journal articleSathianathan V, Avelino A, Charrua A, et al., 2003,
Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons
, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 18, Pages: 2477-2486, ISSN: 0953-816X- Author Web Link
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- Citations: 41
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Journal articleAhluwalia J, Urban L, Bevan S, et al., 2003,
Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 <i>in vitro</i>
, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 17, Pages: 2611-2618, ISSN: 0953-816X- Author Web Link
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- Citations: 143
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Journal articleAhluwalia J, Rang H, Nagy I, 2002,
The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons
, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 16, Pages: 1483-1489, ISSN: 0953-816X- Author Web Link
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- Citations: 54
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