Our team aims to use multi-disciplinary approaches and cutting-edge techniques to respond to key global challenges in Nutrition, Food and Health"
Professor Gary Frost
Head of Section
Lifestyle and particularly diet play a fundamental role in the development of a large number of non-communicable diseases. The Section of Nutrition Research brings together a multidisciplinary group to investigate the interplay between nutrition and human physiology and in doing so seek answers to some of the most intractable public health problems facing humanity such as obesity, type 2 diabetes, undernutrition, gastrointestinal disease.
The group has a focus on the role of the gastrointestinal tract. By integrating clinical, dietary, microbiota/microbiome, gene expression and metabolite data, we aim to identify mechanisms through nutrition and diets that influence human health. This new understanding will help to find targeted means of manipulating diets to improve population-based human health.
The section aims to use multidisciplinary cutting-edge methodology to answer the most challenging health problems. It has a broad focus on obesity, type 2 diabetes, undernutrition, ageing and gastrointestinal disease.
Key studies, research groups and collaborations
- The centre for Translational Nutrition and Food Research
- Microbiome@Imperial Network
- Gut Health
- Centre for Digestive and Gut Health
Head of Nutrition Research - Professor Gary Frost
Prof Frost qualified as a dietitian in 1982 and has always maintained a clinical input throughout his career. He was appointed to Professor of Nutrition and Dietetics at Imperial College Jan 2008. Prior to this, for 18 years, Gary had worked at Hammersmith Hospital. Over his time at Hammersmith, he gained his PhD in Nutrition and was appointed Honorary Reader in Nutrition at Imperial College.
Research group leads
Research group leads
Professor Gary Frost
Professor Frost is working on a number of projects and studies, including:
- BBSRC collaborative project between the Quadram Institute and Imperial College - aims to investigate how food structure affect the gastrointestinal environment is up and running (PI Prof Gary Frost)
Prof Kath Maitland and Prof Gary Frost have recently received an Imperial College Confidence in Concept Award to develop a new feed to support gut health in undernourished children in East Africa. This will build on their ongoing work on intestinal permeability which has the ambition to decrease gut-derived sepsis.
Professor Elaine Holmes
Professor Holmes is a Professor of Chemical Biology and has over 25 years’ experience in metabonomic technology and its applications. Her focus is on the discovery and development of metabolic biomarkers of health and disease in personalised healthcare and population studies with significant contributions to cardiovascular, neuroscience and infectious disease research. Recently she has driven large-scale profiling efforts defining the concept of the metabolome-wide association study (MWAS) in molecular epidemiology, specifically exploring the link between hypertension, diet and metabolic profiles. She has also developed methods for characterizing gut microbiome host metabolic interactions and has applied these to the study of gastrointestinal related diseases including colorectal cancer, obesity and IBD.
Dr Jonathan Swann
Dr Swann's research group focuses on developing metabolomic tools to investigate the biochemical interplay between the microbiome and the mammalian host and how this cross-talk can influence the development and health of the host. Dr Swann’s team is also exploring the impact of malnutrition and infections on the infant metabolic system and their long-term consequences for health and disease and how these outcomes can be modulated through various interventions.
Dr Isabel Garcia-Perez
Dr Garcia-Perez is an expert in analytical chemistry and multiplatform metabolic profiling analysis. She has built a bridge between analytical chemistry techniques and clinical nutrition in order to pursue her passion to adapt analytical technology to beneficially impact public health. Specifically, she has developed tools for monitoring individuals and their response to diet and lifestyle interventions. For example, a urine test, which can give an instant profile of an individual’s diet. As an NIHR Fellow, her main research focuses on Precision nutrition and its role in the prevention and management of non-communicable diseases.
Dr Simon Gabe
Dr Gabe's group at St Mark's investigates the interplay between the bowel itself and the gut microbiome. Surgery to remove parts of the bowel has a devastating effect on nutrient absorption as well as on the microbiome and metabolism. We are looking at specific diseases, different bowel anatomies, the effect of intravenous nutrition and feeding different parts of the bowel as well as the adaptive processes after re-joining parts of the intestine together.
Dr Edward Chambers
Dr Chambers's research investigates the interplay between dietary fibre intake and the functional role of the gut microbiome in human health. This work primarily focuses on the effects of gut-derived short chain fatty acids on metabolic responses in the liver and skeletal muscle.
Dr Jia Li
Dr Li's research group employs functional microbiomics approaches to investigate the metabolic crosstalk of host-gut microbiota-diet. The research focuses on gene-environmental interactions and how they can help predict disease risk and personalise interventions.
Dr Christina Prechtl (Project Management and Clinical Trials)
Dr Prechtl has many years of experience in the field of obesity and diabetes and helps with the coordination and management of commercially and publicly funded clinical trials and studies.