Imperial College London
Alternate

Professor Alan Boobis OBE

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Toxicology
 
 
 
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Contact

 

a.boobis Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

597 results found

Boobis AR, 2010, Untitled, FOOD AND CHEMICAL TOXICOLOGY, Vol: 48, Pages: 771-771, ISSN: 0278-6915

Journal article

Boobis AR, Cohen SM, Doerrer NG, Galloway SM, Haley PJ, Hard GC, Hess FG, Macdonald JS, Thibault S, Wolf DC, Wright Jet al., 2009, A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards, TOXICOLOGIC PATHOLOGY, Vol: 37, Pages: 714-732, ISSN: 0192-6233

Journal article

Boobis A, 2009, Critical analysis of literature on low dose synergy for use of TTC in screening chemical mixtures for risk assessment, 46th Congress of the European-Societies-of-Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S51-S51, ISSN: 0378-4274

Conference paper

Burnett K, Boobis A, Pollitt F, Battershill Jet al., 2009, Risk assessment of mixtures of mutagenic and carcinogenic chemicals: A regulatory perspective from the UK, 46th Congress of the European-Societies-of-Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S271-S271, ISSN: 0378-4274

Conference paper

Koh YKK, Chiu TY, Boobis AR, Scrimshaw MD, Bagnall JP, Soares A, Pollard S, Cartmell E, Lester JNet al., 2009, Influence of Operating Parameters on the Biodegradation of Steroid Estrogens and Nonylphenolic Compounds during Biological Wastewater Treatment Processes, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 43, Pages: 6646-6654, ISSN: 0013-936X

Journal article

Culleres DB, Boesten J, Bolognesi C, Boobis A, Büchert A, Capri E, Coggon D, Hardy A, Hart A, Köpp H, Liess M, Luttik R, Meyer O, Michaelidou-Canna S, Montforts M, Moretto A, Müller M, Ossendorp B, Steurbaut W, Tasheva M, Vleminckx Cet al., 2009, Updating the opinion related to the revision of annexes II and III to council directive 91/414/EEC concerning the placing of plant protection products on the market - residues: Scientific opinion of the panel on plant protection products and their residues (PPR), EFSA Journal, Vol: 7

The European Food Safety Authority (EFSA) asked its Panel on Plant Protection Products and their Residues to review the Opinions of the PPR Panel issued in 2006 and 2007 related to the revision of Annexes II and III to Council Directive 91/414/EEC (data requirements) concerning the placing of plant protection products on the market. The present opinion is an update to the existing opinion on Annex II & III - Residues (EFSA, 2006c). The PPR Panel notes that since the publication of it previous opinion, eight OECD test guidelines and four OECD guidance documents in the field of residues have become available and recommends this new information be thoroughly considered in the establishment of the data requirements in annexes II and III to Directive 91/414/EC. Moreover, when the new Regulation of the European Parliament and of the Council on the placing of plant protection products on the market is in place, it may again be necessary to define additional requirements to address certain issues e.g. pesticides which may disrupt the endocrine system, safeners and synergists, co-formulants. In addition, the PPR Panel cannot at present give a definitive statement on whether or not the data requirements given in Annex II and III are sufficient to gauge risks of nanopesticides, since such an assessment would require substantial scientific efforts and time which could not be provided within the frame of the present mandate. The PPR Panel emphasises that the recommendations in its previous opinion still stand.

Journal article

Kapitulnik J, Pelkonen O, Gundert-Remy U, Dahl SG, Boobis ARet al., 2009, Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models, EXPERT OPINION ON THERAPEUTIC TARGETS, Vol: 13, Pages: 867-887, ISSN: 1472-8222

Journal article

Chiu TY, Koh YKK, Paterakis N, Boobis AR, Cartmell E, Richards KH, Lester JN, Scrimshaw MDet al., 2009, The significance of sample mass in the analysis of steroid estrogens in sewage sludges and the derivation of partition coefficients in wastewaters, JOURNAL OF CHROMATOGRAPHY A, Vol: 1216, Pages: 4923-4926, ISSN: 0021-9673

Journal article

Zhu Z, Edwards RJ, Boobis AR, 2009, Increased Expression of Histone Proteins during Estrogen-Mediated Cell Proliferation, Environmental Health Perspectives, Vol: 117, Pages: 928-934, ISSN: 0091-6765

Background: There is concern about the potential risk posed by compounds with estrogen-like activity present in the environment. As previous studies have shown that combined exposure to such compounds results in dose additivity, it should be possible to assess estrogen exposure with suitable biomarkers of effect.Objectives: Our goal was to identify candidate protein biomarkers of effect for estrogenic compounds.Methods: In the search for biomarkers, we assessed the effect of several estrogenic compounds on the expression profile of proteins in breast-derived cell lines varying in their estrogen receptor (ER) phenotype using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. We identified responsive proteins, after separating them by SDS-polyacrylamide gel electrophoresis, and analyzing the trypsin-digested proteins by tandem mass spectrometry.Results: The estrogenic compounds 17β-estradiol, genistein, bisphenol A, and endosulfan produced similar protein profile changes in MCF-7 cells (phenotype: ERα+/ERβ+), but had no effect on MDA-MB-231 (ERα−/ERβ+), MCF-10F (ERα−/ERβ+), or MCF-10A (ERα−/ERβ−) cells. The most responsive proteins in MCF-7 cells were identified as histones H2A, H2B, H3, and H4. Histone levels were not increased in cell lines that showed no proliferative response to estrogens despite their rapid intrinsic growth rate in culture.Conclusion: Our results indicate that ER-mediated cell proliferation results in up-regulation of core histone proteins.

Journal article

Koh YKK, Chiu TY, Paterakis N, Boobis A, Scrimshaw MD, Lester JN, Cartmell Eet al., 2009, Fate and occurrence of alkylphenolic compounds in sewage sludges determined by liquid chromatography tandem mass spectrometry, ENVIRONMENTAL TECHNOLOGY, Vol: 30, Pages: 1415-1424, ISSN: 0959-3330

Journal article

Julien E, Boobis AR, Olin SS, 2009, The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds, CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, Vol: 49, Pages: 682-689, ISSN: 1040-8398

Journal article

Boobis AR, Daston GP, Preston RJ, Olin SSet al., 2009, Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens, CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, Vol: 49, Pages: 690-707, ISSN: 1040-8398

Journal article

Boobis A, Watelet J-B, Whomsley R, Benedetti MS, Demoly P, Tipton Ket al., 2009, Drug interactions, DRUG METABOLISM REVIEWS, Vol: 41, Pages: 486-527, ISSN: 0360-2532

Journal article

Idahosa E, Rushton L, Boobis AR, 2008, Systematic review of epidemiological evidence for use in the framework approach for analysing the human relevance of an animal mode of action, Annual Congress of the British-Toxicological-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 15-15, ISSN: 0300-483X

Conference paper

Martin OV, Shialis T, Lester JN, Scrimshaw MD, Boobis AR, Voulvoulis Net al., 2008, Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis, Environmental Health Perspectives, Vol: 116, Pages: 149-157, ISSN: 1552-9924

Journal article

Cohen SM, Boobis AR, Meek MEB, Preston RJ, McGregor DBet al., 2008, 4-aminobiphenyl and DNA reactivity: Case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action for humans, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 36, Pages: 803-819, ISSN: 1040-8444

Journal article

Dellarco VL, McGregor D, Berry C, Cohen SM, Boobis ARet al., 2008, Thiazopyr and thyroid disruption: Case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 36, Pages: 793-801, ISSN: 1040-8444

Journal article

Boobis AR, Cohen SM, Dellarco V, McGregor D, Meek MEB, Vickers C, Willcocks D, Farland Wet al., 2008, IPCS framework for analyzing the relevance of a cancer mode of action for humans, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 36, Pages: 781-792, ISSN: 1040-8444

Journal article

Zhu Z, Edwards RJ, Boobis AR, 2008, Proteomic analysis of human breast cell lines using SELDI-TOF MS shows that mixtures of estrogenic compounds exhibit simple similar action (concentration additivity), TOXICOLOGY LETTERS, Vol: 181, Pages: 93-103, ISSN: 0378-4274

Journal article

Koh YKK, Chiu TY, Boobis AR, Cartmell E, Pollard SJT, Scrimshaw MD, Lester JNet al., 2008, A sensitive and robust method for the determination of alkylphenol polyethoxylates and their carboxylic acids and their transformation in a trickling filter wastewater treatment plant, CHEMOSPHERE, Vol: 73, Pages: 551-556, ISSN: 0045-6535

Journal article

Martin O, Shialis T, Lester J, Scrimshaw M, Boobis A, Voulvoulis Net al., 2008, Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis., Cien Saude Colet, Vol: 13, Pages: 1601-1618

Male reproductive tract abnormalities such as hypospadias and cryptorchidism, and testicular cancer have been proposed to comprise a common syndrome together with impaired spermatogenesis with a common etiology resulting from the disruption of gonadal development during fetal life, the testicular dysgenesis syndrome (TDS). The only quantitative summary estimate of the link between prenatal exposure to estrogenic agents and testicular cancer was published over 10 years ago; other reviews of the link between estrogenic compounds, other than the potent pharmaceutical estrogen diethylstilbestrol (DES), and TDS end points have remained inconclusive. We conducted a quantitative meta-analysis of the association between the end points related to TDS and prenatal exposure to estrogenic agents. Inclusion in this analysis was based on mechanistic criteria, and the plausibility of an estrogen receptor (ER)-alpha-mediated mode of action was specifically explored. Eight studies were included, investigating the etiology of hypospadias and/or cryptorchidism that had not been identified in previous systematic reviews. Four additional studies of pharmaceutical estrogens yielded a statistically significant updated summary estimate for testicular cancer. Results of the subset analyses point to the existence of unidentified sources of heterogeneity between studies or within the study population.

Journal article

Boobis AR, Ossendorp BC, Banasiak U, Hamey PY, Sebestyen I, Moretto Aet al., 2008, Cumulative risk assessment of pesticide residues in food, TOXICOLOGY LETTERS, Vol: 180, Pages: 137-150, ISSN: 0378-4274

Journal article

Martin OV, Shialis T, Boobis AR, Voulvoulis N, Lester JN, Scrimshaw MDet al., 2008, Defective spermatogenesis: martin et Al. Respond., Environmental Health Perspectives, Vol: 116, Pages: A332-A332, ISSN: 0091-6765

Journal article

Zhu Z, Boobis AR, Edwards RJ, 2008, Identification of estrogen-responsive proteins in MCF-7 human breast cancer cells using label-free quantitative proteomics, PROTEOMICS, Vol: 8, Pages: 1987-2005, ISSN: 1615-9853

Journal article

Koh YKK, Chiu TY, Boobis A, Cartmell E, Scrimshaw MD, Lester JNet al., 2008, Treatment and removal strategies for estrogens from wastewater, ENVIRONMENTAL TECHNOLOGY, Vol: 29, Pages: 245-267, ISSN: 0959-3330

Journal article

Meek MEB, Berry C, Boobis AR, Cohen SM, Hartley M, Munn S, Olin S, Schlatter J, Vickers Cet al., 2008, Re:: !Guyton,Kathryn Z., !Barone,Stanley, Jr., !Brown,Rebecca C., !Euling,Susan Y., !Jinot,Jennifer, !Makris,Susan (2008).: Mode of action frameworks:: A critical analysis.: Journal of toxicology and environmental health, part B, 11(1): 16-31, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, Vol: 11, Pages: 681-683, ISSN: 1093-7404

Journal article

Boobis AR, Doe JE, Heinrich-Hirsch B, Meek MEB, Munn S, Ruchirawat M, Schlatter J, Seed J, Vickers Cet al., 2008, IPCS framework for analyzing the relevance of a noncancer mode of action for humans, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 38, Pages: 87-96, ISSN: 1040-8444

Journal article

Pelkonen O, Kapitulnik J, Gundert-Remy U, Boobis AR, Stockis Aet al., 2008, Local kinetics and dynamics of xenobiotics, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 38, Pages: 697-720, ISSN: 1040-8444

Journal article

Azzi A, Russell RM, Scott JM, Yetley EA, Halliwell B, Rayman M, Boobis AR, Katan MB, Cashman KD, Taylor CL, Shekelle P, Ernst E, Przyrembel H, Coates PM, Wharton B, Aggett PJet al., 2007, Discussion, Pages: 36-45, ISSN: 1528-2511

Conference paper

Aggett PJ, Alexander J, Azzi A, Boobis AR, Coates PM, Manach C, Przyrembel H, Rayman M, Scott JM, Stocker R, Taylor CL, Yetley EA, Yong ELet al., 2007, Final discussion, Pages: 212-218, ISSN: 1528-2511

Conference paper

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