Imperial College London
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Dr Aubrey Cunnington

Faculty of Medicine, Department of Infectious Disease

Professor of Paediatric Infectious Disease
 
 
 
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Contact

 

+44 (0)20 7594 3695a.cunnington

 
 
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Location

 

244Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patel:2023:10.1001/jamanetworkopen.2023.14291,
author = {Patel, H and Sintou, A and Chowdhury, RA and Rothery, S and Iacob, AO and Prasad, S and Rainer, PP and Martinón-Torres, F and Sancho-Shimizu, V and Shimizu, C and Dummer, K and Tremoulet, AH and Burns, JC and Sattler, S and Levin, M and DIAMONDS, consortium},
doi = {10.1001/jamanetworkopen.2023.14291},
journal = {JAMA Network Open},
pages = {1--11},
title = {Evaluation of autoantibody binding to cardiac tissue in multisystem inflammatory syndrome in children and COVID-19 vaccination-induced myocarditis.},
url = {http://dx.doi.org/10.1001/jamanetworkopen.2023.14291},
volume = {6},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IMPORTANCE: Cardiac dysfunction and myocarditis have emerged as serious complications of multisystem inflammatory syndrome in children (MIS-C) and vaccines against SARS-CoV-2. Understanding the role of autoantibodies in these conditions is essential for guiding MIS-C management and vaccination strategies in children. OBJECTIVE: To investigate the presence of anticardiac autoantibodies in MIS-C or COVID-19 vaccine-induced myocarditis. DESIGN, SETTING, AND PARTICIPANTS: This diagnostic study included children with acute MIS-C or acute vaccine myocarditis, adults with myocarditis or inflammatory cardiomyopathy, healthy children prior to the COVID-19 pandemic, and healthy COVID-19 vaccinated adults. Participants were recruited into research studies in the US, United Kingdom, and Austria starting January 2021. Immunoglobulin G (IgG), IgM, and IgA anticardiac autoantibodies were identified with immunofluorescence staining of left ventricular myocardial tissue from 2 human donors treated with sera from patients and controls. Secondary antibodies were fluorescein isothiocyanate-conjugated antihuman IgG, IgM, and IgA. Images were taken for detection of specific IgG, IgM, and IgA deposits and measurement of fluorescein isothiocyanate fluorescence intensity. Data were analyzed through March 10, 2023. MAIN OUTCOMES AND MEASURES: IgG, IgM and IgA antibody binding to cardiac tissue. RESULTS: By cohort, there were a total of 10 children with MIS-C (median [IQR] age, 10 [13-14] years; 6 male), 10 with vaccine myocarditis (median age, 15 [14-16] years; 10 male), 8 adults with myocarditis or inflammatory cardiomyopathy (median age, 55 [46-63] years; 6 male), 10 healthy pediatric controls (median age, 8 [13-14] years; 5 male), and 10 healthy vaccinated adults (all older than 21 years, 5 male). No antibody binding above background was observed in human cardiac tissue treated with sera from pediatric patients with MIS-C or vaccine myocarditis. One of the 8 adult patients with myocarditi
AU  - Patel,H
AU  - Sintou,A
AU  - Chowdhury,RA
AU  - Rothery,S
AU  - Iacob,AO
AU  - Prasad,S
AU  - Rainer,PP
AU  - Martinón-Torres,F
AU  - Sancho-Shimizu,V
AU  - Shimizu,C
AU  - Dummer,K
AU  - Tremoulet,AH
AU  - Burns,JC
AU  - Sattler,S
AU  - Levin,M
AU  - DIAMONDS,consortium
DO  - 10.1001/jamanetworkopen.2023.14291
EP  - 11
PY  - 2023///
SN  - 2574-3805
SP  - 1
TI  - Evaluation of autoantibody binding to cardiac tissue in multisystem inflammatory syndrome in children and COVID-19 vaccination-induced myocarditis.
T2  - JAMA Network Open
UR  - http://dx.doi.org/10.1001/jamanetworkopen.2023.14291
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37200028
UR  - https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805011
UR  - http://hdl.handle.net/10044/1/104647
VL  - 6
ER  -
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