Imperial College London

Dr Chris Cantwell

Faculty of EngineeringDepartment of Aeronautics

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 5123c.cantwell Website

 
 
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Location

 

Department of Aeronautics, Room 217City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

38 results found

Cantwell CD, Nielsen AS, 2018, A Minimally Intrusive Low-Memory Approach to Resilience for Existing Transient Solvers, Journal of Scientific Computing, ISSN: 0885-7474

JOURNAL ARTICLE

Chowdhury RA, Tzortzis KN, Dupont E, Selvadurai S, Perbellini F, Cantwell CD, Ng FS, Simon AR, Terracciano CM, Peters NSet al., 2018, Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Handa BS, Roney CH, Houston C, Qureshi NA, Li X, Pitcher DS, Chowdhury RA, Lim PB, Dupont E, Niederer SA, Cantwell CD, Peters NS, Ng FSet al., 2018, Analytical approaches for myocardial fibrillation signals., Comput Biol Med

Atrial and ventricular fibrillation are complex arrhythmias, and their underlying mechanisms remain widely debated and incompletely understood. This is partly because the electrical signals recorded during myocardial fibrillation are themselves complex and difficult to interpret with simple analytical tools. There are currently a number of analytical approaches to handle fibrillation data. Some of these techniques focus on mapping putative drivers of myocardial fibrillation, such as dominant frequency, organizational index, Shannon entropy and phase mapping. Other techniques focus on mapping the underlying myocardial substrate sustaining fibrillation, such as voltage mapping and complex fractionated electrogram mapping. In this review, we discuss these techniques, their application and their limitations, with reference to our experimental and clinical data. We also describe novel tools including a new algorithm to map microreentrant circuits sustaining fibrillation.

JOURNAL ARTICLE

Houston C, Tzortzis KN, Roney C, Saglietto A, Pitcher DS, Cantwell CD, Chowdhury RA, Ng FS, Peters NS, Dupont Eet al., 2018, Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 119, Pages: 155-164, ISSN: 0022-2828

JOURNAL ARTICLE

Kim M-Y, Sikkel MB, Hunter RJ, Haywood GA, Tomlinson DR, Tayebjee MH, Ali R, Cantwell CD, Gonna H, Sandler B, Limb E, Furniss G, Mrcp DP, Begg G, Dhillon G, Hill NJ, O'Neill J, Francis DP, Lim PB, Peters NS, Linton NWF, Kanagaratnam Pet al., 2018, A Novel Approach to Mapping the Atrial Ganglionated Plexus Network by Generating a Distribution Probability Atlas., J Cardiovasc Electrophysiol

INTRODUCTION: The ganglionated plexuses (GPs) of the intrinsic cardiac autonomic system are implicated in arrhythmogenesis. GP localization by stimulation of the epicardial fat pads to produce atrioventricular dissociating (AVD) effects is well described. We determined the anatomical distribution of the left atrial GPs that influence AV dissociation. METHODS AND RESULTS: High frequency stimulation was delivered through a Smart-Touch™ catheter in the left atrium of patients undergoing atrial fibrillation (AF) ablation. 3D locations of points tested throughout the entire chamber were recorded on the CARTO™ system. Impact on the AV conduction was categorized as ventricular asystole, bradycardia or no effect. CARTO™ maps were exported, registered and transformed onto a reference left atrial geometry using a custom software, enabling data from multiple patients to be overlaid. In 28 patients, 2108 locations were tested and 283 sites (13%) demonstrated atrioventricular dissociation effects (AVD-GP). There were 10 AVD-GPs (IQR 11.5) per patient. 80% (226) produced asystole and 20% (57) showed bradycardia. The distribution of the two groups were very similar. Highest probability of AVD-GPs (>20%) were identified in: infero-septal portion (41%) and right inferior pulmonary vein base (30%) of the posterior wall, right superior pulmonary vein antrum (31%). CONCLUSION: It is feasible to map the entire left atrium for AVD-GPs prior to AF ablation. Aggregated data from multiple patients, producing a distribution probability atlas of AVD-GPs, identified three regions with a higher likelihood for finding AVD-GPs and these matched the histological descriptions. This approach could be used to better characterise the autonomic network. This article is protected by copyright. All rights reserved.

JOURNAL ARTICLE

Leong KMW, Ng FS, Roney C, Cantwell C, Shun-Shin MJ, Linton NWF, Whinnett ZI, Lefroy DC, Davies DW, Harding SE, Lim PB, Francis D, Peters NS, Varnava AM, Kanagaratnam Pet al., 2018, Repolarization abnormalities unmasked with exercise in sudden cardiac death survivors with structurally normal hearts, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 29, Pages: 115-126, ISSN: 1045-3873

JOURNAL ARTICLE

Xu H, Cantwell CD, Monteserin C, Eskilsson C, Engsig-Karup AP, Sherwin SJet al., 2018, Spectral/hp element methods: Recent developments, applications, and perspectives, JOURNAL OF HYDRODYNAMICS, Vol: 30, Pages: 1-22, ISSN: 1001-6058

JOURNAL ARTICLE

Cantwell C, Sherwin S, 2017, Nektar++

Nektar++ is a tensor product based finite element package designed to allow one to construct efficient classical low polynomial order h-type solvers (where h is the size of the finite element) as well as higher p-order piecewise polynomial order solvers.

SOFTWARE

Moxey D, Cantwell CD, Mengaldo G, Serson D, Ekelschot D, Peiró J, Sherwin SJ, Kirby RMet al., 2017, Towards p-Adaptive Spectral/hp Element Methods for Modelling Industrial Flows, Pages: 63-79, ISSN: 1439-7358

© 2017, Springer International Publishing AG. There is an increasing requirement from both academia and industry for high-fidelity flow simulations that are able to accurately capture complicated and transient flow dynamics in complex geometries. Coupled with the growing availability of high-performance, highly parallel computing resources, there is therefore a demand for scalable numerical methods and corresponding software frameworks which can deliver the next-generation of complex and detailed fluid simulations to scientists and engineers in an efficient way. In this article we discuss recent and upcoming advances in the use of the spectral/hp element method for addressing these modelling challenges. To use these methods efficiently for such applications, is critical that computational resolution is placed in the regions of the flow where it is needed most, which is often not known a priori. We propose the use of spatially and temporally varying polynomial order, coupled with appropriate error estimators, as key requirements in permitting these methods to achieve computationally efficient high-fidelity solutions to complex flow problems in the fluid dynamics community.

CONFERENCE PAPER

Roney CH, Cantwell CD, Bayer JD, Qureshi NA, Lim PB, Tweedy JH, Kanagaratnam P, Peters NS, Vigmond EJ, Ng FSet al., 2017, Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 10, ISSN: 1941-3149

JOURNAL ARTICLE

Roney CH, Cantwell CD, Qureshi NA, Chowdhury RA, Dupont E, Lim PB, Vigmond EJ, Tweedy JH, Ng FS, Peters NSet al., 2017, Rotor Tracking Using Phase of Electrograms Recorded During Atrial Fibrillation, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 45, Pages: 910-923, ISSN: 0090-6964

JOURNAL ARTICLE

Bolls A, Cantwell CD, Moxey D, Serson D, Sherwin SJet al., 2016, An adaptable parallel algorithm for the direct numerical simulation of incompressible turbulent flows using a Fourier spectral/hp element method and MPI virtual topologies, COMPUTER PHYSICS COMMUNICATIONS, Vol: 206, Pages: 17-25, ISSN: 0010-4655

JOURNAL ARTICLE

Cantwell C, Sherwin S, 2016, Nektar++

Nektar++ is a tensor product based finite element package designed to allow one to construct efficient classical low polynomial order h-type solvers (where h is the size of the finite element) as well as higher p-order piecewise polynomial order solvers.

SOFTWARE

Moxey D, Cantwell CD, Kirby RM, Sherwin SJet al., 2016, Optimising the performance of the spectral/hp element method with collective linear algebra operations, COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, Vol: 310, Pages: 628-645, ISSN: 0045-7825

JOURNAL ARTICLE

Ali RL, Cantwell CD, Qureshi NA, Roney CH, Lim PB, Sherwin SJ, Siggers JH, Peters NSet al., 2015, Automated fiducial point selection for reducing registration error in the co-localisation of left atrium electroanatomic and imaging data, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Publisher: IEEE, Pages: 1989-1992, ISSN: 1557-170X

CONFERENCE PAPER

Cantwell C, Sherwin SJ, Moxey D, 2015, Nektar++

Nektar++ is a tensor product based finite element package designed to allow one to construct efficient classical low polynomial order h-type solvers (where h is the size of the finite element) as well as higher p-order piecewise polynomial order solvers.

SOFTWARE

Cantwell C, sherwin SJ, moxey DM, 2015, Nektar++

Nektar++ is a tensor product based finite element package designed to allow one to construct efficient classical low polynomial order h-type solvers (where h is the size of the finite element) as well as higher p-order piecewise polynomial order solvers.

SOFTWARE

Cantwell CD, Moxey D, Comerford A, Bolis A, Rocco G, Mengaldo G, De Grazia D, Yakovlev S, Lombard J-E, Ekelschot D, Jordi B, Xu H, Mohamied Y, Eskilsson C, Nelson B, Vos P, Biotto C, Kirby RM, Sherwin SJet al., 2015, Nektar plus plus : An open-source spectral/hp element framework, COMPUTER PHYSICS COMMUNICATIONS, Vol: 192, Pages: 205-219, ISSN: 0010-4655

JOURNAL ARTICLE

Cantwell CD, Roney CH, Ng FS, Siggers JH, Sherwin SJ, Peters NSet al., 2015, Techniques for automated local activation time annotation and conduction velocity estimation in cardiac mapping, COMPUTERS IN BIOLOGY AND MEDICINE, Vol: 65, Pages: 229-242, ISSN: 0010-4825

JOURNAL ARTICLE

Claus S, Cantwell CD, Phillips TN, 2015, Spectral/hp element methods for plane Newtonian extrudate swell, COMPUTERS & FLUIDS, Vol: 116, Pages: 105-117, ISSN: 0045-7930

JOURNAL ARTICLE

Cohen J, Cantwell C, Moxey D, Austing P, Darlington J, Sherwin S, Nowell J, Guo Xet al., 2015, TemPSS: A service providing software parameter templates and profiles for scientific HPC, IEEE International Conference On eScience, Publisher: IEEE, Pages: 78-87, ISSN: 2325-372X

CONFERENCE PAPER

Cohen J, Moxey D, Cantwell C, Austing P, Darlington J, Sherwin Set al., 2015, POSITION PAPER: Ensuring an Effective User Experience when Managing and Running Scientific HPC Software, IEEE ACM 1st International Workshop on Software Engineering for High Performance Computing in Science (SE4HPCS), Publisher: IEEE, Pages: 56-59

CONFERENCE PAPER

Roney CH, Tzortzis KN, Cantwell CD, Qureshi NA, Ali RL, Lim PB, Siggers JH, Ng FS, Peters NSet al., 2015, A Technique for Visualising Three-Dimensional Left Atrial Cardiac Activation Data in Two Dimensions with Minimal Distance Distortion, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Publisher: IEEE, Pages: 7296-7299, ISSN: 1557-170X

CONFERENCE PAPER

Tzortzis KN, Roney CH, Qureshi NA, Ng FS, Phang BL, Sherwin SJ, Peters NS, Cantwell CDet al., 2015, Influence of Left Atrial Geometry on Rotor Core Trajectories in a Model of Atrial Fibrillation, 2015 Comp in Cardiol Conference (CinC), Publisher: IEEE, Pages: 481-484, ISSN: 0276-6574

CONFERENCE PAPER

Ali RL, Cantwell CD, Roney CH, Qureshi NA, Lim PB, Siggers JH, Sherwin SJ, Peters NSet al., 2014, A novel method for quantifying localised correlation of late-gadolinium intensity with conduction velocity, 41st Computing in Cardiology Conference (CinC), Publisher: IEEE, Pages: 193-196, ISSN: 0276-6574

CONFERENCE PAPER

Bolis A, Cantwell CD, Kirby RM, Sherwin SJet al., 2014, From h to p efficiently: optimal implementation strategies for explicit time-dependent problems using the spectral/hp element method, INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Vol: 75, Pages: 591-607, ISSN: 0271-2091

JOURNAL ARTICLE

Cantwell CD, Roney CH, Ali RL, Qureshi NA, Lim PB, Peters NSet al., 2014, A Software Platform for the Comparative Analysis of Electroanatomic and Imaging Data including Conduction Velocity Mapping, 36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Publisher: IEEE, Pages: 1591-1594, ISSN: 1557-170X

CONFERENCE PAPER

Cantwell CD, Sherwin SJ, Moxey D, 2014, Nektar++

Nektar++ is a tensor product based finite element package designed to allow one to construct efficient classical low polynomial order h-type solvers (where h is the size of the finite element) as well as higher p-order piecewise polynomial order solvers.

SOFTWARE

Cantwell CD, Yakovlev S, Kirby RM, Peters NS, Sherwin SJet al., 2014, High-order spectral/hp element discretisation for reaction-diffusion problems on surfaces: Application to cardiac electrophysiology, JOURNAL OF COMPUTATIONAL PHYSICS, Vol: 257, Pages: 813-829, ISSN: 0021-9991

JOURNAL ARTICLE

Roney CH, Cantwell CD, Qureshi NA, Ali RL, Chang ETY, Lim PB, Sherwin SJ, Peters NS, Siggers JH, Ng FSet al., 2014, An Automated Algorithm for Determining Conduction Velocity, Wavefront Direction and Origin of Focal Cardiac Arrhythmias Using a Multipolar Catheter, 36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Publisher: IEEE, Pages: 1583-1586, ISSN: 1557-170X

CONFERENCE PAPER

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