Imperial College London
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ProfessorDenisDoorly

Faculty of Engineering, Department of Aeronautics

Professor of Fluid Mechanics
 
 
 
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Contact

 

d.doorly

 
 
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Location

 

313ACity and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rose:2019:10.1002/mrm.27561,
author = {Rose, JN and Nielles-Vallespin, S and Ferreira, PF and Firmin, DN and Scott, AD and Doorly, DJ},
doi = {10.1002/mrm.27561},
journal = {Magnetic Resonance in Medicine},
pages = {2759--2773},
title = {Novel insights into in-vivo diffusion tensor cardiovascular magnetic resonance using computational modelling and a histology-based virtual microstructure},
url = {http://dx.doi.org/10.1002/mrm.27561},
volume = {81},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeTo develop histologyinformed simulations of diffusion tensor cardiovascular magnetic resonance (DTCMR) for typical invivo pulse sequences and determine their sensitivity to changes in extracellular space (ECS) and other microstructural parameters.MethodsWe synthesised the DTCMR signal from Monte Carlo random walk simulations. The virtual tissue was based on porcine histology. The cells were thickened and then shrunk to modify ECS. We also created idealised geometries using cuboids in regular arrangement, matching the extracellular volume fraction (ECV) of 16–40%. The simulated voxel size was 2.8 × 2.8 × 8.0 mm3 for pulse sequences covering short and long diffusion times: Stejskal–Tanner pulsedgradient spin echo, secondorder motioncompensated spin echo, and stimulated echo acquisition mode (STEAM), with clinically available gradient strengths.ResultsThe primary diffusion tensor eigenvalue increases linearly with ECV at a similar rate for all simulated geometries. Mean diffusivity (MD) varies linearly, too, but is higher for the substrates with more uniformly distributed ECS. Fractional anisotropy (FA) for the histologybased geometry is higher than the idealised geometry with low sensitivity to ECV, except for the long mixing time of the STEAM sequence. Varying the intracellular diffusivity (DIC) results in large changes of MD and FA. Varying extracellular diffusivity or using stronger gradients has minor effects on FA. Uncertainties of the primary eigenvector orientation are reduced using STEAM.ConclusionsWe found that the distribution of ECS has a measurable impact on DTCMR parameters. The observed sensitivity of MD and FA to ECV and DIC has potentially interesting applications for interpreting invivo DTCMR parameters.
AU  - Rose,JN
AU  - Nielles-Vallespin,S
AU  - Ferreira,PF
AU  - Firmin,DN
AU  - Scott,AD
AU  - Doorly,DJ
DO  - 10.1002/mrm.27561
EP  - 2773
PY  - 2019///
SN  - 0740-3194
SP  - 2759
TI  - Novel insights into in-vivo diffusion tensor cardiovascular magnetic resonance using computational modelling and a histology-based virtual microstructure
T2  - Magnetic Resonance in Medicine
UR  - http://dx.doi.org/10.1002/mrm.27561
UR  - http://hdl.handle.net/10044/1/64823
VL  - 81
ER  -
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