Imperial College London
Portrait Picture

Professor Hashim Ahmed

Faculty of Medicine, Department of Surgery & Cancer

Chair in Urology (Clinical)
 
 
 
//

Contact

 

hashim.ahmed

 
 
//

Location

 

5L28Lab BlockCharing Cross Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Santaolalla:2021:10.3389/frai.2021.769582,
author = {Santaolalla, A and Hulsen, T and Davis, J and Ahmed, HU and Moore, CM and Punwani, S and Attard, G and McCartan, N and Emberton, M and Coolen, A and Van, Hemelrijck M},
doi = {10.3389/frai.2021.769582},
journal = {Frontiers in Artificial Intelligence},
title = {The ReIMAGINE multimodal warehouse: using artificial intelligence for accurate risk stratification of prostate cancer},
url = {http://dx.doi.org/10.3389/frai.2021.769582},
volume = {4},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction. Prostate cancer (PCa) is the most frequent cancer diagnosis in men worldwide. Our ability to identify those men whose cancer will decrease their lifespan and/or quality of life remains poor. The ReIMAGINE Consortium has been established to improve PCa diagnosis. Materials and methods. MRI will likely become the future cornerstone of the risk-stratification process for men at risk of early prostate cancer. We will, for the first time, be able to combine the underlying molecular changes in PCa with the state-of-the-art imaging. ReIMAGINE Screening invites men for MRI and PSA evaluation. ReIMAGINE Risk includes men at risk of prostate cancer based on MRI, and includes biomarker testing. Results. Baseline clinical information, genomics, blood, urine, fresh prostate tissue samples, digital pathology and radiomics data will be analysed. Data will be de-identified, stored with correlated mpMRI disease endotypes and linked with long term follow-up outcomes in an instance of the Philips Clinical Data Lake, consisting of cloud-based software. The ReIMAGINE platform includes application programming interfaces and a user interface that allows users to browse data, select cohorts, manage users and access rights, query data, and more. Connection to analytics tools such as Python allows statistical and stratification method pipelines to run profiling regression analyses. Discussion. The ReIMAGINE Multimodal Warehouse comprises a unique data source for PCa research, to improve risk stratification for PCa and inform clinical practice. The de-identified dataset characterized by clinical, imaging, genomics and digital pathology PCa patient phenotypes will be a valuable resource for the scientific and medical community.
AU  - Santaolalla,A
AU  - Hulsen,T
AU  - Davis,J
AU  - Ahmed,HU
AU  - Moore,CM
AU  - Punwani,S
AU  - Attard,G
AU  - McCartan,N
AU  - Emberton,M
AU  - Coolen,A
AU  - Van,Hemelrijck M
DO  - 10.3389/frai.2021.769582
PY  - 2021///
SN  - 2624-8212
TI  - The ReIMAGINE multimodal warehouse: using artificial intelligence for accurate risk stratification of prostate cancer
T2  - Frontiers in Artificial Intelligence
UR  - http://dx.doi.org/10.3389/frai.2021.769582
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34870187
UR  - http://hdl.handle.net/10044/1/93501
VL  - 4
ER  -
Download