Imperial College London
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Dr James A Bull

Faculty of Natural Sciences, Department of Chemistry

Reader in Synthetic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5811j.bull Website

 
 
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Location

 

501bMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Higham:2023:10.1021/acs.orglett.3c01783,
author = {Higham, J and Ma, T and Bull, J},
doi = {10.1021/acs.orglett.3c01783},
journal = {Organic Letters},
pages = {5285--5290},
title = {Dual copper and aldehyde catalyzed transient C-H sulfonylation of benzylamines},
url = {http://dx.doi.org/10.1021/acs.orglett.3c01783},
volume = {25},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This study reports the first example of using a dual catalytic system with copper(II) acetate and 2-hydroxynicotinaldehyde to achieve transient C(sp2)–H sulfonylation of benzylamines with sulfinate salts via a dynamically formed imine directing group. Manganese(IV) oxide was identified as an effective oxidant and base. Computational DFT investigations suggest that the TDG lowers the energy barrier for an acetate-mediated, turnover limiting C–H activation step and subsequent combination of the cupracycle with a RSO2 radical.
AU  - Higham,J
AU  - Ma,T
AU  - Bull,J
DO  - 10.1021/acs.orglett.3c01783
EP  - 5290
PY  - 2023///
SN  - 1523-7052
SP  - 5285
TI  - Dual copper and aldehyde catalyzed transient C-H sulfonylation of benzylamines
T2  - Organic Letters
UR  - http://dx.doi.org/10.1021/acs.orglett.3c01783
UR  - https://pubs.acs.org/doi/10.1021/acs.orglett.3c01783
UR  - http://hdl.handle.net/10044/1/105377
VL  - 25
ER  -
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