Julian Marchesi graduated from Cardiff University with a PhD in biochemistry (1992) and became interested in the role bacteria play in ecosystem function. During his post-doctoral years he developed an interest in the contribution of uncultured microbes to the maintenance and function of ecosystems i.e. molecular microbial ecology. He subsequently secured a Wellcome Trust Fellowship which extended his molecular microbial ecology interest and investigated, with culture independent methods, the diversity and distribution of genes involved in biodegradation of priority pollutants in pristine environments. After a short time investigating the deep biosphere he obtained a Lectureship (2001) in the Department of Microbiology, University College Cork, Ireland where he transferred these “omic” skills into the human gut and started to investigate the human gut ecosystem in health and disease. After 7 years in UCC, he moved back to Cardiff University in 2008 to a senior lectureship, where he investigates the role of the gut microbiome in maintaining host health and initiating diseases not only of the gut, but throughout the host system. In 2015 he was promoted to Professor at Cardiff and in 2016 to Professor at Imperial College London.
His work uses a variety of “omic” approaches such as metagenomics, metatranscriptomics, metabonomics and molecular ecology. Over his 22 year career he has authored over 190 journal articles and peer-reviewed publications and is a senior editor for ISME Journal. He is the current chair of the BSG's Gut Microbiota for Health Expert Panel and chaired the Microbiology Society's "Unlocking the Microbiome " working group and the subsequent publication.
et al., 2021, Identifying the factors influencing outcome in probiotic studies in overweight and obese patients – host or microbiome?, Gut, ISSN:0017-5749
et al., 2020, Letter: Intestinal Microbiota Transfer – Updating the Nomenclature to Increase Acceptability, Alimentary Pharmacology and Therapeutics, ISSN:0269-2813
et al., 2020, Multiomic features associated with mucosal healing and inflammation in paediatric Crohn's disease., Aliment Pharmacol Ther
et al., 2020, Metabonomics and the Gut Microbiome Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease., J Crohns Colitis, Vol:14, Pages:1090-1102
et al., 2020, Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial derived metabolites, Gut Microbes, Vol:12, ISSN:1949-0976