Imperial College London

ProfessorKathrynMaitland

Faculty of MedicineDepartment of Medicine

Professor of Tropical Paediatric Infectious Diseases
 
 
 
//

Contact

 

+44 (0)025 4417 525044k.maitland CV

 
 
//

Assistant

 

Dr Peter Norsworthy +44 (0)20 7594 3891

 
//

Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaNorfolk PlaceSt Mary's Campus

//

Summary

 

Summary

She is a Professor of Paediatric Tropical Infectious Diseases at the Faculty of Medicine Imperial College, London, Director of the ICCARE at the Institute of Global Health Innovtion, Imperial College, London and an Honorary Fellow at MRC Clinical Trials Unit, University College, London. Over the last 15 years she has been based full-time at the East Africa, where she leads a research group whose major research portfolio includes severe malaria, bacterial sepsis and severe malnutrition in children and clinical trials in emergency care. Her team have highlighted the unique importance of emergency-care research as a highly targeted and cost-effective means of tackling childhood mortality in resource-limited sub-Saharan Africa, previously neglected as an area for specific funder or policy investment. Her group have undertaken pioneering clinical investigative research in resource-poor settings by undertaking high-quality physiological studies and clinical trials, generating the essential evidence base for patient management and informing both national and international policy. To enable such translational research to occur, she has built up a network of African sites, investing in both training and local capacity development, bringing sophisticated technologies and applying them in real-life circumstances to study common and important diseases of Africa.

Her team conducted the largest trial of critically children ever undertaken in Africa, (FEAST trial) examining fluid resuscitation strategies in children with severe febrile illness, showing that fluid boluses increased mortality, which went on to win the prestigious BMJ Research Paper of the Year award.  

Current work

Her team is currently running the TRACT trial, which is investigating transfusion and other treatment strategies in 4000 African children severe life-threatening anaemia.   In 2017 her group will start the COAST trial (Children Oxygenation Administration Strategies Trial) which will examine the optimum oxygen saturation threshold for which oxygen should be targeted and how best to administer oxygen, by high flow or low flow, in 4200 severely ill African children.  Currently, her group have active collaborations across Africa, within Europe, South East Asia and Australia. 

Key References

 

Clinical TrialS

Maitland K, George EC, Evans JA, Kiguli S, Olupot-Olupot P, Akech SO, Opoka RO, Engoru C, Nyeko R, Mtove G et al: Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med 2013, 11:68.10.1186/1741-7015-11-68

Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T et al: Mortality after fluid bolus in African children with severe infection. The New England journal of medicine 2011, 364:2483-2495.10.1056/NEJMoa1101549

Maitland K, Akech SO, Russell EC: Mortality after Fluid Bolus in African Children with Sepsis: Reply. The New England journal of medicine 2011, 365:1348-1353.10.1056/NEJMc1108712

Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, Bojang K, Olaosebikan R, Anunobi N, Maitland K et al: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010, 376:1647-1657.10.1016/S0140-6736(10)61924-1

Akech SO, Karisa J, Nakamya P, Boga M, Maitland K: Phase II trial of isotonic fluid resuscitation in Kenyan children with severe malnutrition and hypovolaemia. BMC pediatrics 2010, 10:71.10.1186/1471-2431-10-71

Akech SO, Jemutai J, Timbwa M, Kivaya E, Boga M, Fegan G, Maitland K: Phase II trial on the use of Dextran 70 or starch for supportive therapy in Kenyan children with severe malaria. Critical care medicine 2010, 38:1630-1636.10.1097/CCM.0b013e3181e81165

Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, Newton CR, Levin M, Maitland K: Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial. PLoS clinical trials 2006, 1:e21.10.1371/journal.pctr.0010021

Maitland K, Pamba A, English M, Peshu N, Marsh K, Newton C, Levin M: Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005, 40:538-545.10.1086/427505

Maitland K, Pamba A, English M, Peshu N, Levin M, Marsh K, Newton CR: Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion. British journal of haematology 2005, 128:393-400.10.1111/j.1365-2141.2004.05312.x

Malaria

 

Olupot-Olupot P, Urban BC, Jemutai J, Nteziyaremye J, Fanjo HM, Karanja H, Karisa J, Ongodia P, Bwonyo P, Gitau EN et al: Endotoxaemia is common in children with Plasmodium falciparum malaria. BMC infectious diseases 2013, 13:117.10.1186/1471-2334-13-117

Yacoub S, Lang HJ, Shebbe M, Timbwa M, Ohuma E, Tulloh R, Maitland K: Cardiac function and hemodynamics in Kenyan children with severe malaria. Critical care medicine 2010, 38:940-945.10.1097/CCM.0b013e3181cd114a

Ogetii GN, Akech S, Jemutai J, Boga M, Kivaya E, Fegan G, Maitland K: Hypoglycaemia in severe malaria, clinical associations and relationship to quinine dosage. BMC infectious diseases 2010, 10:334.10.1186/1471-2334-10-334

Malnutrition

Talbert A, Thuo N, Karisa J, Chesaro C, Ohuma E, Ignas J, Berkley JA, Toromo C, Atkinson S, Maitland K: Diarrhoea complicating severe acute malnutrition in Kenyan children: a prospective descriptive study of risk factors and outcome. PloS one 2012, 7:e38321.10.1371/journal.pone.0038321

Thuo N, Ungphakorn W, Karisa J, Muchohi S, Muturi A, Kokwaro G, Thomson AH, Maitland K: Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation. The Journal of antimicrobial chemotherapy 2011, 66:2336-2345.10.1093/jac/dkr314

Bejon P, Mohammed S, Mwangi I, Atkinson SH, Osier F, Peshu N, Newton CR, Maitland K, Berkley JA: Fraction of all hospital admissions and deaths attributable to malnutrition among children in rural Kenya. The American journal of clinical nutrition 2008, 88:1626-1631.10.3945/ajcn.2008.26510

Seaton C, Ignas J, Muchohi S, Kokwaro G, Maitland K, Thomson AH: Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition. The Journal of antimicrobial chemotherapy 2007, 59:681-689.10.1093/jac/dkl561

Maitland K, Berkley JA, Shebbe M, Peshu N, English M, Newton CR: Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol? PLoS medicine 2006, 3:e500.10.1371/journal.pmed.0030500

Berkley J, Mwangi I, Griffiths K, Ahmed I, Mithwani S, English M, Newton C, Maitland K: Assessment of severe malnutrition among hospitalized children in rural Kenya: comparison of weight for height and mid upper arm circumference. JAMA : the journal of the American Medical Association 2005, 294:591-597.10.1001/jama.294.5.591

Selected Publications

Journal Articles

Maitland K, 2015, Management of severe paediatric malaria in resource-limited settings., Bmc Med, Vol:13

Church J, Maitland K, 2014, Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review., Bmc Med, Vol:12

Kiguli S, Akech SO, Mtove G, et al., 2014, WHO guidelines on fluid resuscitation in children: missing the FEAST data., Bmj, Vol:348

Maitland K, George EC, Evans JA, et al., 2013, Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial, BMC Medicine, Vol:11, ISSN:1741-7015

Dondorp AM, Fanello CI, Hendriksen ICE, et al., 2010, Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial, The Lancet, Vol:376, ISSN:0140-6736, Pages:1647-1657

Maitland K, Akech SO, Russell EC, 2011, Mortality after Fluid Bolus in African Children with Sepsis REPLY, New England Journal of Medicine, Vol:365, ISSN:0028-4793, Pages:1351-1353

Maitland K, Kiguli S, Opoka RO, et al., 2011, Mortality after Fluid Bolus in African Children with Severe Infection, New England Journal of Medicine, Vol:364, ISSN:0028-4793, Pages:2483-2495

Akech S, Ledermann H, Maitland K, 2010, Choice of fluids for resuscitation in children with severe infection and shock: systematic review, British Medical Journal, Vol:341, ISSN:0959-535X

Khor CC, Vannberg FO, Chapman SJ, et al., 2010, CISH and Susceptibility to Infectious Diseases, New England Journal of Medicine, Vol:362, ISSN:0028-4793, Pages:2092-2101

Akech SO, Jemutai J, Timbwa M, et al., 2010, Phase II trial on the use of Dextran 70 or starch for supportive therapy in Kenyan children with severe malaria, Critical Care Medicine, Vol:38, ISSN:0090-3493, Pages:1630-1636

Maitland K, Pamba A, Newton CR, et al., 2003, Response to volume resuscitation in children with severe malaria., Pediatric Critical Care Medicine, Vol:4, ISSN:1529-7535, Pages:426-431

More Publications