Publications
258 results found
Schapira A, 1998, More on malaria transmissibility, PARASITOLOGY TODAY, Vol: 14, Pages: 293-293, ISSN: 0169-4758
Maitland K, Williams TN, 1998, Malaria mortality: The Pacific enigma, PARASITOLOGY TODAY, Vol: 14, Pages: 258-259, ISSN: 0169-4758
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- Citations: 14
Williams TN, Maitland K, Martin PMV, et al., 1998, Splenic size in homozygous α<SUP>+</SUP> thalassaemia, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 100, Pages: 611-612, ISSN: 0007-1048
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- Citations: 1
Barnardo MCNM, Welsh KI, Vilches C, et al., 1998, Allele-specific HLA-B(*)15 typing by PCR-SSP and its application to four distinct ethnic populations, Tissue Antigens, Vol: 51, Pages: 293-300, ISSN: 0001-2815
We present a set of primer mixes for the allele-specific typing of the HLA-B(*)15 group by PCR-SSP. The set comprises 46 primer mixes which are designed to unequivocally resolve all but two of the 666 possible combinations of the B(*)15 alleles, B(*)1501-37 (B(*)1536 sequence unavailable). A core subset of 34 of the 46 mixes can be used alone to give a high resolution B(*)15 typing set. This allows for the identification of each B(*)15 allele when present as the only B(*)15 allele and the majority of the possible B(*)15 homozygotic combinations. The method was validated using reference DNA samples and the B(*)15 allele frequency in 4 distinct ethnic populations was investigated. The results show that these populations contain predominantly mutually exclusive sets of B(*)15 alleles.
Rees DJ, 1998, Alpha thalassaemia is associated with increased soluble transferrin receptor levels, British Journal of Haematology, Vol: 103, Pages: 365-369
Maitland K, Williams TN, Kotecka BM, et al., 1997, Plasma chloroquine concentrations in young and older malaria patients treated with chloroquine, ACTA TROPICA, Vol: 66, Pages: 155-161, ISSN: 0001-706X
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- Citations: 7
Maitland K, Williams TN, Peto TEA, et al., 1997, Absence of malaria-specific mortality in children in an area of hyperendemic malaria, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 91, Pages: 562-566, ISSN: 0035-9203
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- Citations: 37
Williams TN, Maitland K, Phelps L, et al., 1997, Plasmodium vivax: a cause of malnutrition in young children, QJM, Vol: 90, Pages: 751-757, ISSN: 1460-2725
We studied the aetiology of malnutrition in a cohort of 1511 children < 10 years old in Espiritu Santo, Vanuatu. Malnutrition was categorized using standard anthropometric criteria as: underweight [weight-for-age (WA) Z score < -2], wasting [weight-for-height (WH) Z < -2], or stunting [height-for-age (HA) Z < -2]. On multiple logistic regression analysis, the only factors significantly associated with wasting were age < 5 years [OR (95% CI) 1.8 (1.2-2.9), p = 0.01] and having suffered one or more episodes of clinical P. vivax malaria in the 6 months preceding nutritional assessment [OR 2.4 (1.3-4.4), p = 0.006]. The incidence of P. vivax infection was significantly higher during the 6 months preceding assessment in underweight vs. non-underweight children [incidence rate ratio (IRR) 2.6 (1.5-4.4), p < or = 0.0001). These groups had similar incidences of clinical P. falciparum infection during the same period [IRR 1.1 (0.57-2.1) p = 0.8] and of either species during the 6 months following assessment [IRR P. vivax 1.3 (0.9-2.0) p = 0.2; IRR P. falciparum 1.3 (0.9-1.9) p = 0.2]. In these children, P. vivax malaria was a major predictor of acute malnutrition; P. falciparum was not. Wasting neither predisposed to nor protected against malaria of either species. Although P. vivax malaria is generally regarded as benign, it may produce considerable global mortality through malnutrition.
Maitland CI, 1997, Plasmodium vivax and P. falciparum: Biological interactions and the possibility of cross-species immunity, Parasitology Today, Vol: 13, Pages: 227-230
Bryan JH, Burwell C, Maitland K, et al., 1996, Culicine mosquitoes (Diptera: Culicidae) attracted to humans on Espiritu Santo, Vanuatu, MEDICAL AND VETERINARY ENTOMOLOGY, Vol: 10, Pages: 101-102, ISSN: 0269-283X
Williams DK, 1996, Red blood cell phenotypes in the α + thalassaemias from early childhood to maturity, British Journal of Haematology, Vol: 95, Pages: 266-272
Williams JB, 1996, High incidence of malaria in α-thalassaemic children, Nature, Vol: 383, Pages: 522-525
Maitland K, Williams TN, Bennett S, et al., 1996, The interaction between Plasmodium falciparum and P. vivax in children on Espiritu Santo island, Vanuatu, Trans R Soc Trop Med Hyg, Vol: 90, Pages: 614-620, ISSN: 0035-9203
Studies of the prevalence and incidence of malaria were conducted in children < 10 years old living in 10 rural villages on the island of Espiritu Santo, Vanuatu, south-west Pacific. Malaria prevalence remained stable at 30% throughout the year but the relative contributions of the 2 major species were highly dependent on season. Plasmodium falciparum predominated in the long wet season (November-May) and P. vivax in the dry season (June-October). Case definitions for malaria, derived using a multiple logistic regression method, showed that parasite densities associated with clinical disease were low; case definitions for P. falciparum (> 1000 parasites/microL in children > 1 year old and > 500 microL in infants) and P. vivax (> 500 parasites/microL at all ages) were both associated with a specificity and sensitivity of > 90%. Like prevalence data, malaria morbidity was highly seasonal; 80% of clinical P. falciparum infections occurred in the wet season and 66% of clinical P. vivax in the dry season. Mixed infections were rare. Malaria was important cause of morbidity with children < 5 years old experiencing 1.3-3.0 episodes of clinical malaria per year and 23% of fevers being attributable to malaria in this age group. Children aged 5-9 years continued to suffer one episode of clinical malaria per year. The peak incidence of P. vivax malaria occurred earlier in life than the peak incidence of P. falciparum malaria. The possible interactions between these 2 parasite species are discussed.
BRINDLE PM, MAITLAND K, WILLIAMS TN, et al., 1995, A SURVEY FOR THE RARE BLOOD-GROUP ANTIGEN VARIANTS, EN(A-), GERBICH NEGATIVE AND DUFFY NEGATIVE ON ESPIRITU-SANTO, VANUATU IN THE SOUTH-PACIFIC, HUMAN HEREDITY, Vol: 45, Pages: 211-214, ISSN: 0001-5652
Williams DH, 1995, Malaria sporozoite rates for Anopheles farauti s.s. Laveran (Diptera: Culicidae) from Vanuatu, Annals of Tropical Medicine and Parasitology, Vol: 89, Pages: 305-307
Ganczakowski DJ, 1995, Thalassaemia in Vanuatu, South-West Pacific: Frequency and haematological phenotypes of young children, British Journal of Haematology, Vol: 89, Pages: 485-495
Maitland K, How Do We Treat Children with Severe Malaria?, Advances in Experimental Medicine and Biology, Publisher: Springer US, Pages: 9-21, ISBN: 9780387317830
Maitland K, Wills B, Tropical infections: malaria and dengue, Infectious Diseases in the Pediatric Intensive Care Unit, Editors: Nadel, Giroir P, London, Publisher: Springer-Verlag
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