Imperial College London
Alternate

ProfessorKathMaitland

Faculty of Medicine, Department of Surgery & Cancer

Professor of Tropical Paediatric Infectious Disease
 
 
 
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Contact

 

k.maitland CV

 
 
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Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaQueen Elizabeth and Queen Mary HospitalSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Obonyo:2019:10.1016/j.mex.2019.05.005,
author = {Obonyo, NG and Byrne, L and Tung, J-P and Simonova, G and Diab, SD and Dunster, KR and Passmore, MR and Boon, A-C and See, Hoe L and Engkilde-Pedersen, S and Esguerra-Lallen, A and Fauzi, MH and Pimenta, LP and Millar, JE and Fanning, JP and Van, Haren F and Anstey, CM and Cullen, L and Suen, J and Shekar, K and Maitland, K and Fraser, JF},
doi = {10.1016/j.mex.2019.05.005},
journal = {MethodsX},
pages = {1124--1132},
title = {Pre-clinical study protocol: Blood transfusion in endotoxaemic shock},
url = {http://dx.doi.org/10.1016/j.mex.2019.05.005},
volume = {6},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The Surviving Sepsis Campaign (SCC) and the American College of Critical Care Medicine (ACCM) guidelines recommend blood transfusion in sepsis when the haemoglobin concentration drops below 7.0 g/dL and 10.0 g/dL respectively, while the World Health Organisation (WHO) guideline recommends transfusion in septic shock ‘if intravenous (IV) fluids do not maintain adequate circulation’, as a supportive measure of last resort. Volume expansion using crystalloid and colloid fluid boluses for haemodynamic resuscitation in severe illness/sepsis, has been associated with adverse outcomes in recent literature. However, the volume expansion effect(s) following blood transfusion for haemodynamic circulatory support, in severe illness remain unclear with most previous studies having focused on evaluating effects of either different RBC storage durations (short versus long duration) or haemoglobin thresholds (low versus high threshold) pre-transfusion.•    We describe the protocol for a pre-clinical randomised controlled trial designed to examine haemodynamic effect(s) of early volume expansion using packed RBCs (PRBCs) transfusion (before any crystalloids or colloids) in a validated ovine-model of hyperdynamic endotoxaemic shock.•    Additional exploration of mechanisms underlying any physiological, haemodynamic, haematological, immunologic and tissue specific-effects of blood transfusion will be undertaken including comparison of effects of short (≤5 days) versus long (≥30 days) storage duration of PRBCs prior to transfusion.
AU  - Obonyo,NG
AU  - Byrne,L
AU  - Tung,J-P
AU  - Simonova,G
AU  - Diab,SD
AU  - Dunster,KR
AU  - Passmore,MR
AU  - Boon,A-C
AU  - See,Hoe L
AU  - Engkilde-Pedersen,S
AU  - Esguerra-Lallen,A
AU  - Fauzi,MH
AU  - Pimenta,LP
AU  - Millar,JE
AU  - Fanning,JP
AU  - Van,Haren F
AU  - Anstey,CM
AU  - Cullen,L
AU  - Suen,J
AU  - Shekar,K
AU  - Maitland,K
AU  - Fraser,JF
DO  - 10.1016/j.mex.2019.05.005
EP  - 1132
PY  - 2019///
SN  - 2215-0161
SP  - 1124
TI  - Pre-clinical study protocol: Blood transfusion in endotoxaemic shock
T2  - MethodsX
UR  - http://dx.doi.org/10.1016/j.mex.2019.05.005
UR  - http://hdl.handle.net/10044/1/74086
VL  - 6
ER  -
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