Publications
205 results found
Thum MY, Saso S, Clancy N, et al., 2015, Imaging of organ viability during uterine transplantation surgery, 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 34-34, ISSN: 0268-1161
Borley J, WilhelmBenartzi C, Yazbek J, et al., 2015, Radiological predictors of cytoreductive outcomes in patients with advanced ovarian cancer, BJOG: An International Journal of Obstetrics & Gynaecology, Vol: 122, Pages: 843-849, ISSN: 1470-0328
<jats:sec><jats:title>Objective</jats:title><jats:p>To assess site of disease on preoperative computed tomography (<jats:styled-content style="fixed-case">CT</jats:styled-content>) to predict surgical debulking in patients with ovarian cancer.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Two‐phase retrospective cohort study.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>West London Gynaecological Cancer Centre, <jats:styled-content style="fixed-case">UK</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Population</jats:title><jats:p>Women with stage 3 or 4, ovarian, fallopian or primary peritoneal cancer undergoing cytoreductive surgery.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Preoperative <jats:styled-content style="fixed-case">CT</jats:styled-content> images were reviewed by experienced radiologists to assess the presence or absence of disease at predetermined sites. Multivariable stepwise logistic regression models determined sites of disease which were significantly associated with surgical outcomes in the test (<jats:italic>n</jats:italic> = 111) and validation (<jats:italic>n</jats:italic> = 70) sets.</jats:p></jats:sec><jats:sec><jats:title>Main outcome measures</jats:title><jats:p>Sensitivity and specificity of <jats:styled-content style="fixed-case">CT</jats:styled-content> in predicting surgical outcome.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Stepwise logistic regression identified that the presence of lung metastasis, pleural effusion, deposits on the large‐bowel mesentery
Sayasneh A, Kaijser J, Preisler J, et al., 2015, Accuracy of ultrasonography performed by examiners with varied training and experience in predicting specific pathology of adnexal masses, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 45, Pages: 605-612, ISSN: 0960-7692
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- Citations: 23
Saso S, Sawyer R, O'Neill NM, et al., 2015, Trachelectomy during pregnancy: What has experience taught us?, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, Vol: 41, Pages: 640-645, ISSN: 1341-8076
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- Citations: 1
Wahba J, Natoli M, Whilding L, et al., 2015, Synergistic immuno-chemotherapy for ovarian cancer, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 122, Pages: 362-362, ISSN: 1470-0328
Bourne T, Bennett P, Bobdiwala S, et al., 2015, Surgeon acquittal in female genital mutilation case: Dharmasena case illustrates what is wrong with complaints procedures, BMJ, Vol: 350, ISSN: 1756-1833
Rizzuto I, Stavraka C, Chatterjee J, et al., 2015, Risk of Ovarian Cancer Relapse Score A Prognostic Algorithm to Predict Relapse Following Treatment for Advanced Ovarian Cancer, International Journal of Gynecological Cancer, Vol: 25, Pages: 416-422, ISSN: 1525-1438
Objective: The aim of this study was to construct a prognostic index that predicts risk ofrelapse in women who have completed first-line treatment for ovarian cancer (OC).Methods: A database of OC cases from 2000 to 2010 was interrogated for InternationalFederation of Gynecology and Obstetrics stage, grade and histological subtype of cancer,preoperative and posttreatment CA-125 level, presence or absence of residual disease aftercytoreductive surgery and on postchemotherapy computed tomography scan, and time toprogression and death. The strongest predictors of relapse were included into an algorithm,the Risk of Ovarian Cancer Relapse (ROVAR) score.Results: Three hundred fifty-four cases of OC were analyzed to generate the ROVARscore. Factors selected were preoperative serum CA-125, International Federation ofGynecology and Obstetrics stage and grade of cancer, and presence of residual disease atposttreatment computed tomography scan. In the validation data set, the ROVAR score had asensitivity and specificity of 94% and 61%, respectively. The concordance index for thevalidation data set was 0.91 (95% confidence interval, 0.85-0.96). The score allows patientstratification into low (G0.33), intermediate (0.34Y0.67), and high (90.67) probability ofrelapse.Conclusions: The ROVAR score stratifies patients according to their risk of relapsefollowing first-line treatment for OC. This can broadly facilitate the appropriate tailoring ofposttreatment care and support.
Saso S, Petts G, Thum M-Y, et al., 2015, Achieving uterine auto-transplantation in a sheep model using iliac vessel anastomosis: a short-term viability study, ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol: 94, Pages: 245-252, ISSN: 0001-6349
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- Citations: 19
Saso S, Clarke A, Bracewell-Milnes T, et al., 2015, Survey of perceptions of health care professionals in the United Kingdom toward uterine transplant, PROGRESS IN TRANSPLANTATION, Vol: 25, Pages: 56-63, ISSN: 1526-9248
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- Citations: 15
Saso S, Petts G, David AL, et al., 2015, Achieving an early pregnancy following allogeneic uterine transplantation in a rabbit model, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 185, Pages: 164-169, ISSN: 0301-2115
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- Citations: 22
Parente-Pereira AC, Shmeeda H, Whilding LM, et al., 2014, Adoptive Immunotherapy of Epithelial Ovarian Cancer with Vγ9Vδ2 T Cells, Potentiated by Liposomal Alendronic Acid, JOURNAL OF IMMUNOLOGY, Vol: 193, Pages: 5557-5566, ISSN: 0022-1767
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- Citations: 35
Papakonstantinou K, Kyrgiou M, Lyons D, et al., 2014, Management of stage Ia1 squamous cervical cancer and the importance of excision margins: a retrospective study of long-term outcome after 25 years of follow-up, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, Vol: 211, ISSN: 0002-9378
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- Citations: 10
Castanon A, Landy R, Brocklehurst P, et al., 2014, Risk of preterm delivery with increasing depth of excision for cervical intraepithelial neoplasia in England: nested case-control study, BMJ: British Medical Journal, Vol: 349, Pages: 1-11, ISSN: 0959-535X
Objective To determine the association between depth of excision of cervical intraepithelial neoplasia and risk of preterm birth.Design Case-control study nested in record linkage cohort study.Setting 12 hospitals in England.Participants From a cohort of 11 471 women with at least one histological sample taken at colposcopy and a live singleton birth (before or after colposcopy), 1313 women with a preterm birth (20-36 weeks) were identified and frequency matched on maternal age at delivery, parity, and study site to 1313 women with term births (38-42 weeks).Main outcome measures Risk of preterm birth and very/extreme preterm birth by depth of excisional treatment of the cervical transformation zone.Results After exclusions, 768 preterm births (cases) and 830 term births after colposcopy remained. The risk of preterm birth was no greater in women with a previous small (<10 mm) excision (absolute risk 7.5%, 95% confidence interval 6.0% to 8.9%) than in women with a diagnostic punch biopsy (7.2%, 5.9% to 8.5%). Women with a medium (10-14 mm) (absolute risk 9.6%; relative risk 1.28, 0.98 to 1.68), large (15-19 mm) (15.3%; 2.04, 1.41 to 2.96), or very large (≥20 mm) excision (18.0%; 2.40, 1.53 to 3.75) had a higher risk of preterm delivery than those with small excision. The same pattern was seen in 161 women with very/extremely preterm births (20-31 weeks) and with increasing volume excised. Most births were conceived more than three years after colposcopy, and the risk of preterm delivery did not seem to depend on time from excision to conception.Conclusions The risk of preterm birth is at most minimally affected by a small excision. Larger excisions, particularly over 15 mm or 2.66 cm3, are associated with a doubling of the risk of both preterm and very preterm births. The risk does not decrease with increasing time from excision to conception. Efforts should be made to excise the entire lesion while preserving as much healthy cervical tissue as possible. Close
Saso S, Petts G, Chatterjee J, et al., 2014, Uterine allotransplantation in a rabbit model using aorto-caval anastomosis: a long-term viability study, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 182, Pages: 185-193, ISSN: 0301-2115
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- Citations: 20
Saso S, Bracewell-Milnes T, Ismail L, et al., 2014, Psychological assessment tool for patients diagnosed with absolute uterine factor infertility and planning to undergo uterine transplantation., J Obstet Gynaecol, Vol: 34, Pages: 504-507
Abstract Uterine transplantation (UTn) has been proposed as a treatment option for women diagnosed with absolute uterine factor infertility (AUFI) and who are willing to bear their own child. AUFI renders a woman 'unconditionally infertile'. For AUFI women in general, UTn may offer a way to re-discover their own femininity through the restoration of fertility. Thus, when faced with a patient who may undergo UTn, the 'holistic approach' takes on an extra meaning. This is because the psychological element is two-sided for these patients. On one side lies the psychology of infertility, and on the other and equally important, is the substantially higher prevalence of psychiatric disorders in transplant candidates and recipients than in the general population. However, the psychology of a potential recipient of a uterine graft in order to bring about fertility has not been adequately explored or reviewed scientifically. We have presented here an outline of the areas which should be included in a psychological assessment for patients wishing to undergo UTn.
Ghaem-Maghami S, 2014, Mini commentary on 'Metabolic tumour volume and total lesion glycolysis, measured using preoperative <SUP>18</SUP>F-FDG PET/CT, predicts the recurrence of endometrial cancer', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 121, Pages: 1106-1106, ISSN: 1470-0328
Hopkins TG, Weir J, Mura M, et al., 2014, The mRNA-binding protein LARP1 is a pro-survival factor that promotes tumourigenicity and chemotherapy resistance in ovarian cancer, EUROPEAN JOURNAL OF CANCER, Vol: 50, Pages: S26-S26, ISSN: 0959-8049
Maine CJ, Aziz NHA, Chatterjee J, et al., 2014, Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer, CANCER IMMUNOLOGY IMMUNOTHERAPY, Vol: 63, Pages: 215-224, ISSN: 0340-7004
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- Citations: 89
Saso S, Hurst S, Chatterjee J, et al., 2014, Test of long- term uterine survival after allogeneic transplantation in rabbits, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, Vol: 40, Pages: 754-762, ISSN: 1341-8076
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- Citations: 17
Kyrgiou M, Valasoulis G, Stasinou S-M, et al., 2014, Proportion of Cervical Excision for CIN as a Predictor of Future Pregnancy Outcomes: A Prospective Study, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 208A-208A, ISSN: 1933-7191
Kyrgiou M, Pugh R, Hird V, et al., 2014, Fertility-Sparing Treatment for Young Women with Atypical Hyperplasia and Early Endometrial Cancer with High-Dose Medrocyprogesterone Acetate, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 208A-208A, ISSN: 1933-7191
Clancy NT, Saso S, Stoyanov D, et al., 2014, Multispectral Imaging of Organ Viability during Uterine Transplantation Surgery, Conference on Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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- Citations: 8
Kaijser J, Sayasneh A, Van Hoorde K, et al., 2013, Presurgical diagnosis of adnexal tumours using mathematical models and scoring systems: a systematic review and meta-analysis, HUMAN REPRODUCTION UPDATE, Vol: 20, Pages: 449-462, ISSN: 1355-4786
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- Citations: 142
van der Stegen SJC, Davies DM, Wilkie S, et al., 2013, Preclinical In Vivo Modeling of Cytokine Release Syndrome Induced by ErbB-Retargeted Human T Cells: Identifying a Window of Therapeutic Opportunity?, JOURNAL OF IMMUNOLOGY, Vol: 191, Pages: 4589-4598, ISSN: 0022-1767
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- Citations: 94
Kyrgiou M, Chatterjee J, Lyus R, et al., 2013, The role of cytology and other prognostic factors in endometrial cancer, JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 33, Pages: 729-734, ISSN: 0144-3615
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- Citations: 6
Kyrgiou M, Warwick JANE, Swart A, et al., 2013, LAPAROSCOPIC VERSUS OPEN HYSTERECTOMY FOR EARLY STAGE ENDOMETRIAL CANCER: RESULTS FROM THE MRC ASTEC TRIAL, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 23, ISSN: 1048-891X
Kyrgiou M, Papakonstantinou K, Valasoulis G, et al., 2013, FOLLOW-UP AND OUTCOMES OF WOMEN WITH UNTREATED CIN2 LESIONS: IS THERE A ROLE FOR THE USE OF HPV-RELATED BIOMARKERS, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 23, ISSN: 1048-891X
Hopkins TG, Jayantha C, Gabra H, et al., 2013, OUTCOMES IN MUCINOUS OVARIAN CARCINOMAS: 10 YEARS OF EXPERIENCE IN A TERTIARY CENTRE, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 23, ISSN: 1048-891X
Kyrgiou M, Pugh R, Hird V, et al., 2013, FERTILITY-SPARING TREATMENT FOR YOUNG WOMEN WITH ATYPICAL HYPERPLASIA AND EARLY ENDOMETRIAL CANCERWITH HIGH-DOSE MEDROXYPROGESTERONE ACETATE, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 23, ISSN: 1048-891X
Teo PY, Yang C, Hedrick JL, et al., 2013, Hydrophobic modification of low molecular weight polyethylenimine for improved gene transfection, BIOMATERIALS, Vol: 34, Pages: 7971-7979, ISSN: 0142-9612
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- Citations: 92
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