Imperial College London
Alternate

ProfessorSebastianJohnston

Faculty of Medicine, National Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)7931 376 544s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Psarras:2004:10.1016/s1526-0542(04)90034-6,
author = {Psarras, S and Papadopoulos, NG and Johnston, SL},
doi = {10.1016/s1526-0542(04)90034-6},
journal = {Paediatr Respir Rev},
pages = {S179--S184},
title = {Pathogenesis of respiratory syncytial virus bronchiolitis-related wheezing.},
url = {http://dx.doi.org/10.1016/s1526-0542(04)90034-6},
volume = {5 Suppl A},
year = {2004}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory syncytial virus (RSV) is a common cause of virus infection of the human respiratory tract during the first two years of life, with virtually all children experiencing at least one infection within this period. Although this usually leads to mild respiratory illness, some infants develop more severe disease (bronchiolitis, pneumonia, etc.) affecting the lower airways and frequently requiring hospitalisation. There is evidence that bronchiolitis hospitalisations have increased during the last two decades and many of the hospitalised children develop wheezing later in life. The immune response to the virus is probably a major factor in the development or the expression of the pathological phenotype. In particular, a bias towards type-2 cytokine responses seems to be associated with more severe disease, whereas a type-1 response leads to more effective viral clearance and milder illness. Although the virus by itself triggers a type-1 response, a preexisting type-1 deficiency may contribute to the severity of the disease. In that sense, RSV bronchiolitis may serve as a marker, reflecting predisposition of the individual for virus induced wheezing early in life and/or asthma later in life.
AU  - Psarras,S
AU  - Papadopoulos,NG
AU  - Johnston,SL
DO  - 10.1016/s1526-0542(04)90034-6
EP  - 184
PY  - 2004///
SN  - 1526-0542
SP  - 179
TI  - Pathogenesis of respiratory syncytial virus bronchiolitis-related wheezing.
T2  - Paediatr Respir Rev
UR  - http://dx.doi.org/10.1016/s1526-0542(04)90034-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/14980267
VL  - 5 Suppl A
ER  -
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