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@article{Zunt:2018:10.1016/S1474-4422(18)30387-9,
author = {Zunt, JR and Kassebaum, NJ and Blake, N and Glennie, L and Wright, C and Nichols, E and Abd-Allah, F and Abdela, J and Abdelalim, A and Adamu, AA and Adib, MG and Ahmadi, A and Ahmed, MB and Aichour, AN and Aichour, I and Aichour, MTE and Akseer, N and Al-Raddadi, RM and Alahdab, F and Alene, KA and Aljunid, SM and AlMazora, MA and Khalid and Alvis-Guzman, N and Animut, MD and Anjomshoa, M and Ansha, MG and Asghar, RJ and Avokpaho, EFGA and Awasthi, A and Badali, H and Barac, A and Baernighausen, TW and Bassat, Q and Bedi, N and Belachew, AB and Bhattacharyya, K and Bhutta, ZA and Bijani, A and Butt, ZA and Carvalho, F and Castaneda-Orjuela, CA and Chitheer, A and Choi, J-YJ and Christopher, DJ and Dang, AK and Daryani, A and Demoz, GT and Djalalinia, S and Huyen, PD and Dubey, M and Dubljanin, E and Duken, EE and Zaki, MES and Elyazar, IR and Fakhim, H and Fernandes, E and Fischer, F and Fukumoto, T and Ganji, M and Gebre, AK and Gebremeskel, A and Gessner, BD and Gopalani, SV and Guo},
doi = {10.1016/S1474-4422(18)30387-9},
journal = {Lancet Neurology},
pages = {1061--1082},
title = {Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016},
url = {http://dx.doi.org/10.1016/S1474-4422(18)30387-9},
volume = {17},
year = {2018}
}

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TY  - JOUR
AB  - BackgroundAcute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels and trends of global meningitis burden that could help to guide introduction, continuation, and ongoing development of vaccines and treatment programmes.MethodsThe Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2016 study estimated meningitis burden due to one of four types of cause: pneumococcal, meningococcal, Haemophilus influenzae type b, and a residual category of other causes. Cause-specific mortality estimates were generated via cause of death ensemble modelling of vital registration and verbal autopsy data that were subject to standardised data processing algorithms. Deaths were multiplied by the GBD standard life expectancy at age of death to estimate years of life lost, the mortality component of disability-adjusted life-years (DALYs). A systematic analysis of relevant publications and hospital and claims data was used to estimate meningitis incidence via a Bayesian meta-regression tool. Meningitis deaths and cases were split between causes with meta-regressions of aetiological proportions of mortality and incidence, respectively. Probabilities of long-term impairment by cause of meningitis were applied to survivors and used to estimate years of life lived with disability (YLDs). We assessed the relationship between burden metrics and Socio-demographic Index (SDI), a composite measure of development based on fertility, income, and education.FindingsGlobal meningitis deaths decreased by 21·0% from 1990 to 2016, from 403012 (95% uncertainty interval [UI] 319426–458514) to 318400 (265218–408705). Incident cases globally increased from 2·50 million (95% UI 2·19–2·91) in 1990 to 2·82 million (2·46–3·31) in 2016. Meningitis mortality and incidence were closely related to SDI. The highest mortality rates an
AU  - Zunt,JR
AU  - Kassebaum,NJ
AU  - Blake,N
AU  - Glennie,L
AU  - Wright,C
AU  - Nichols,E
AU  - Abd-Allah,F
AU  - Abdela,J
AU  - Abdelalim,A
AU  - Adamu,AA
AU  - Adib,MG
AU  - Ahmadi,A
AU  - Ahmed,MB
AU  - Aichour,AN
AU  - Aichour,I
AU  - Aichour,MTE
AU  - Akseer,N
AU  - Al-Raddadi,RM
AU  - Alahdab,F
AU  - Alene,KA
AU  - Aljunid,SM
AU  - AlMazora,MA
AU  - Khalid
AU  - Alvis-Guzman,N
AU  - Animut,MD
AU  - Anjomshoa,M
AU  - Ansha,MG
AU  - Asghar,RJ
AU  - Avokpaho,EFGA
AU  - Awasthi,A
AU  - Badali,H
AU  - Barac,A
AU  - Baernighausen,TW
AU  - Bassat,Q
AU  - Bedi,N
AU  - Belachew,AB
AU  - Bhattacharyya,K
AU  - Bhutta,ZA
AU  - Bijani,A
AU  - Butt,ZA
AU  - Carvalho,F
AU  - Castaneda-Orjuela,CA
AU  - Chitheer,A
AU  - Choi,J-YJ
AU  - Christopher,DJ
AU  - Dang,AK
AU  - Daryani,A
AU  - Demoz,GT
AU  - Djalalinia,S
AU  - Huyen,PD
AU  - Dubey,M
AU  - Dubljanin,E
AU  - Duken,EE
AU  - Zaki,MES
AU  - Elyazar,IR
AU  - Fakhim,H
AU  - Fernandes,E
AU  - Fischer,F
AU  - Fukumoto,T
AU  - Ganji,M
AU  - Gebre,AK
AU  - Gebremeskel,A
AU  - Gessner,BD
AU  - Gopalani,SV
AU  - Guo,Y
AU  - Gupta,R
AU  - Hailu,GB
AU  - Haj-Mirzaian,A
AU  - Hamidi,S
AU  - Hay,S
AU  - Henok,A
AU  - Irvani,SSN
AU  - Jha,RP
AU  - Jurisson,M
AU  - Kahsay,A
AU  - Karami,M
AU  - Karch,A
AU  - Kasaeian,A
AU  - Kassa,TD
AU  - Kefale,AT
AU  - Khader,YS
AU  - Khalil,IA
AU  - Khan,EA
AU  - Khang,Y-H
AU  - Khubchandani,J
AU  - Kimokoti,RW
AU  - Kisa,A
AU  - Lami,FH
AU  - Levi,M
AU  - Li,S
AU  - Loy,CT
AU  - Majdan,M
AU  - Majeed,A
AU  - Mantovani,LG
AU  - Martins-Melo,FR
AU  - McAlinden,C
AU  - Mehta,V
AU  - Melese,A
AU  - Memish,ZA
AU  - Mengistu,G
AU  - Mestrovic,T
AU  - Mezgebe,HB
AU  - Miazgowski,B
AU  - Milosevic,B
AU  - Mokdad,AH
AU  - Monasta,L
AU  - Moradi,G
AU  - Moraga,P
AU  - Mousavi,SM
AU  - Mueller,UO
AU  - Murthy,S
AU  - Mustafa,G
AU  - Naheed,A
AU  - Naik,G
AU  - Newton,CRJ
AU  - Nirayo,YL
AU  - Nixon,MR
AU  - Ofori-Asenso,R
AU  - Ogbo,FA
AU  - Olagunju,TO
AU  - Olusanya,BO
AU  - Ortiz,JR
AU  - Owolabi,MO
AU  - Patel,S
AU  - Pinilla-Monsalve,GD
AU  - Postma,MJ
AU  - Qorbani,M
AU  - Rafiei,A
AU  - Rahimi-Movaghar,V
AU  - Reiner,RC
AU  - Renzaho,AMN
AU  - Rezai,MS
AU  - Roba,KT
AU  - Ronfani,L
AU  - Roshandel,G
AU  - Rostami,A
AU  - Safari,S
AU  - Safiri,S
AU  - Sagar,R
AU  - Samy,AM
AU  - Milicevic,MMS
AU  - Sartorius,B
AU  - Sarvi,S
AU  - Sawhney,M
AU  - Saxena,S
AU  - Shafieesabet,A
AU  - Shaikh,MA
AU  - Sharif,M
AU  - Shigematsu,M
AU  - Si,S
AU  - Skiadaresi,E
AU  - Smith,M
AU  - Somayaji,R
AU  - Sufiyan,MB
AU  - Tawye,NY
AU  - Temsah,M-H
AU  - Tortajada-Girbes,M
AU  - Khanh,BT
AU  - Ukwaja,KN
AU  - Ullah,I
AU  - Vujcic,IS
AU  - Wagnew,F
AU  - Waheed,Y
AU  - Weldegwergs,KG
AU  - Winkler,AS
AU  - Wiyeh,AB
AU  - Wiysonge,CS
AU  - Wyper,GMA
AU  - Yimer,EM
AU  - Yonemoto,N
AU  - Zaidi,Z
AU  - Zenebe,ZM
AU  - Feigin,VL
AU  - Vos,T
AU  - Murray,CJL
DO  - 10.1016/S1474-4422(18)30387-9
EP  - 1082
PY  - 2018///
SN  - 1474-4422
SP  - 1061
TI  - Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
T2  - Lancet Neurology
UR  - http://dx.doi.org/10.1016/S1474-4422(18)30387-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000450119300016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/66684
VL  - 17
ER  -

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