Imperial College London
Alternate

ProfessorStuartCook

Faculty of Medicine, Institute of Clinical Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 1346stuart.cook

 
 
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Location

 

RF 16Sydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lim:2018:10.1371/journal.pbio.2004285,
author = {Lim, WK and Davila, S and Teo, JX and Yang, C and Pua, CJ and Blocker, C and Lim, JQ and Ching, J and Yap, JJL and Tan, SY and Sahlen, A and Chin, CW-L and Teh, BT and Rozen, SG and Cook, SA and Yeo, KK and Tan, P},
doi = {10.1371/journal.pbio.2004285},
journal = {PLoS Biology},
pages = {1--18},
title = {Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research},
url = {http://dx.doi.org/10.1371/journal.pbio.2004285},
volume = {16},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The use of consumer-grade wearables for purposes beyond fitness tracking has not been comprehensively explored. We generated and analyzed multidimensional data from 233 normal volunteers, integrating wearable data, lifestyle questionnaires, cardiac imaging, sphingolipid profiling, and multiple clinical-grade cardiovascular and metabolic disease markers. We show that subjects can be stratified into distinct clusters based on daily activity patterns and that these clusters are marked by distinct demographic and behavioral patterns. While resting heart rates (RHRs) performed better than step counts in being associated with cardiovascular and metabolic disease markers, step counts identified relationships between physical activity and cardiac remodeling, suggesting that wearable data may play a role in reducing overdiagnosis of cardiac hypertrophy or dilatation in active individuals. Wearable-derived activity levels can be used to identify known and novel activity-modulated sphingolipids that are in turn associated with insulin sensitivity. Our findings demonstrate the potential for wearables in biomedical research and personalized health.
AU  - Lim,WK
AU  - Davila,S
AU  - Teo,JX
AU  - Yang,C
AU  - Pua,CJ
AU  - Blocker,C
AU  - Lim,JQ
AU  - Ching,J
AU  - Yap,JJL
AU  - Tan,SY
AU  - Sahlen,A
AU  - Chin,CW-L
AU  - Teh,BT
AU  - Rozen,SG
AU  - Cook,SA
AU  - Yeo,KK
AU  - Tan,P
DO  - 10.1371/journal.pbio.2004285
EP  - 18
PY  - 2018///
SN  - 1544-9173
SP  - 1
TI  - Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research
T2  - PLoS Biology
UR  - http://dx.doi.org/10.1371/journal.pbio.2004285
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426253300015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004285
UR  - http://hdl.handle.net/10044/1/98510
VL  - 16
ER  -
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