Imperial College London
Alternate

ProfessorStuartCook

Faculty of Medicine, Institute of Clinical Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 1346stuart.cook

 
 
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Location

 

RF 16Sydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aw:2018:10.1038/s41598-018-33850-9,
author = {Aw, T-C and Huang, W-T and Le, T-T and Pua, C-J and Ang, B and Phua, S-K and Yeo, K-K and Cook, SA and Chin, CWL},
doi = {10.1038/s41598-018-33850-9},
journal = {Scientific Reports},
title = {High-sensitivitycardiac troponinsin cardio-healthy subjects: a cardiovascular magnetic resonance imaging study},
url = {http://dx.doi.org/10.1038/s41598-018-33850-9},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The 99th percentile upper reference limits (URL) of high-sensitivity cardiac troponin (hs-cTn) in healthy subjects are essential for diagnosis and management of cardiovascular diseases. Unless screened stringently, subclinical disease affects the derived URL. In 779 healthy subjects(49% males; 17-88 years) screened by cardiovascular magnetic resonance (CMR), the gold standard for assessing cardiac volumes and myocardial mass; and estimated glomerular filtration rate (eGFR), the 99th percentile URL of hsTnT (Roche) and hs-cTnI (Abbott) were similar to the published URL. The overall 99th percentile URL of hsTnT and hsTnI were 15.2 and 21.2 ng/L, respectively; males had higher values than females (hsTnT: 16.8 versus 11.9 ng/L and hsTnI: 38.8 versus 14.4 ng/L). Correlation between hsTnT and hsTnI was modest (r = 0.45; p < 0.001). A larger proportion of healthy volunteers <60 years had detectable hsTnI compared to hsTnT (n = 534; 30.0% versus 18.3%, p < 0.001). Lower eGFR was an independent clinical determinant of hsTnT, but not hsTnI. Both hs-cTn concentrations were independently associated with myocardial mass and cardiac volumes (p < 0.01 for all), but only hsTnI was independently associated with CMR multi-directional strain measures and extent of LV trabeculations (p < 0.05 for all). Differences exist between hs-cTn assays and may influence their selection depending on cardiac conditions, patient population and local factors.
AU  - Aw,T-C
AU  - Huang,W-T
AU  - Le,T-T
AU  - Pua,C-J
AU  - Ang,B
AU  - Phua,S-K
AU  - Yeo,K-K
AU  - Cook,SA
AU  - Chin,CWL
DO  - 10.1038/s41598-018-33850-9
PY  - 2018///
SN  - 2045-2322
TI  - High-sensitivitycardiac troponinsin cardio-healthy subjects: a cardiovascular magnetic resonance imaging study
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-018-33850-9
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30337631
UR  - http://hdl.handle.net/10044/1/98438
VL  - 8
ER  -
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