Imperial College London
Alternate

ProfessorStuartCook

Faculty of Medicine, Institute of Clinical Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 1346stuart.cook

 
 
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Location

 

RF 16Sydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhang:2018:10.1007/s10334-017-0668-2,
author = {Zhang, S and Le, TT and Kabus, S and Su, B and Hausenloy, DJ and Cook, SA and Chin, CWL and Tan, RS},
doi = {10.1007/s10334-017-0668-2},
journal = {Magnetic Resonance Materials in Physics, Biology and Medicine},
pages = {115--129},
title = {Cardiac magnetic resonance T1 and extracellular volume mapping with motion correction and co-registration based on fast elastic image registration},
url = {http://dx.doi.org/10.1007/s10334-017-0668-2},
volume = {31},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Our aim was to investigate the technical feasibility of a novel motion compensation method for cardiac magntic resonance (MR) T1 and extracellular volume fraction (ECV) mapping. MATERIALS AND METHODS: Native and post-contrast T1 maps were obtained using modified look-locker inversion recovery (MOLLI) pulse sequences with acquisition scheme defined in seconds. A nonrigid, nonparametric, fast elastic registration method was applied to generate motion-corrected T1 maps and subsequently ECV maps. Qualitative rating was performed based on T1 fitting-error maps and overlay images. Local deformation vector fields were produced for quantitative assessment. Intra- and inter-observer reproducibility were compared with and without motion compensation. RESULTS: Eighty-two T1 and 39 ECV maps were obtained in 21 patients with diverse myocardial diseases. Approximately 60% demonstrated clear quality improvement after motion correction for T1 mapping, particularly for the poor-rating cases (23% before vs 2% after). Approximately 67% showed further improvement with co-registration in ECV mapping. Although T1 and ECV values were not clinically significantly different before and after motion compensation, there was improved intra- and inter-observer reproducibility after motion compensation. CONCLUSIONS: Automated motion correction and co-registration improved the qualitative assessment and reproducibility of cardiac MR T1 and ECV measurements, allowing for more reliable ECV mapping.
AU  - Zhang,S
AU  - Le,TT
AU  - Kabus,S
AU  - Su,B
AU  - Hausenloy,DJ
AU  - Cook,SA
AU  - Chin,CWL
AU  - Tan,RS
DO  - 10.1007/s10334-017-0668-2
EP  - 129
PY  - 2018///
SN  - 0968-5243
SP  - 115
TI  - Cardiac magnetic resonance T1 and extracellular volume mapping with motion correction and co-registration based on fast elastic image registration
T2  - Magnetic Resonance Materials in Physics, Biology and Medicine
UR  - http://dx.doi.org/10.1007/s10334-017-0668-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29270904
UR  - http://hdl.handle.net/10044/1/98437
VL  - 31
ER  -
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