Imperial College London
Portrait Picture

Professor Timothy Constandinou

Faculty of Engineering, Department of Electrical and Electronic Engineering

Professor of Bioelectronics
 
 
 
//

Contact

 

+44 (0)20 7594 0790t.constandinou Website

 
 
//

Assistant

 

Miss Izabela Wojcicka-Grzesiak +44 (0)20 7594 0701

 
//

Location

 

B407Bessemer BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@inproceedings{Meimandi:2023:10.1109/BioSensors58001.2023.10280954,
author = {Meimandi, A and Feng, P and Carminati, M and Constandinou, TG and Carrara, S},
doi = {10.1109/BioSensors58001.2023.10280954},
title = {Implantable Biosensor for Brain Dopamine using Microwire-Based Electrodes},
url = {http://dx.doi.org/10.1109/BioSensors58001.2023.10280954},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - This paper systematically demonstrates the feasibility of wirelessly monitoring dopamine concentration in the brain with an implantable biosensor. The biosensor was realized using microwires, and then, the dopamine concentration was measured in-vitro ranging from 0.3 μ M to 2 μ M, corresponding to the physio-pathological concentration range in human brain. The obtained results were used to design and optimise a full-custom CMOS sensor interface for in-vivo dopamine monitoring. The key component of this interface is a potentiostat with a maximum power consumption of 10.24 μ W in a 10kHz sampling frequency. The CMOS interface automatically subtracts the background current up to 2.34 μ A. The obtained sensitivity in dopamine detection has been evaluated in 150μ A/μ M, with a Limit of Detection (LoD) of 33 nM, thus being suitable for dopamine monitoring in human brain.
AU  - Meimandi,A
AU  - Feng,P
AU  - Carminati,M
AU  - Constandinou,TG
AU  - Carrara,S
DO  - 10.1109/BioSensors58001.2023.10280954
PY  - 2023///
TI  - Implantable Biosensor for Brain Dopamine using Microwire-Based Electrodes
UR  - http://dx.doi.org/10.1109/BioSensors58001.2023.10280954
ER  -
Download