Training staff at Pinggu site

Investigators

Team members

The International Study of Macro-and Micro-Nutrients (INTERMAP) is an epidemiological investigation of relationships between micro- and macronutrient intakes, timed 24-hour urinary biochemistry and metabolic phenotypes, and BP.  Data were collected during 1997-1999 on 4,680 women and men ages 40-59 (including metabolomics data) from diverse population samples in USA, People’s Republic of China, Japan and UK at four visits.  Standardized quality-controlled data collection included BP measurements; interviewer-administered in-depth multi-pass 24-hr dietary recalls; questionnaire data on occupation, education, other socio-demographic traits, medical history, and other possible confounders; two timed 24-hr urine collections including 8% split specimens for external quality control.

Urinary aliquots from both 24-hr collections were shipped to a Central Laboratory (Leuven, Belgium), and analysed there for urinary sodium, potassium, calcium, magnesium, urea, creatinine, albumin, and 23 amino acids. Subsequently, all urine specimens were shipped to Imperial College London, where urinary metabolome-wide proton nuclear magnetic resonance (1H NMR) spectroscopic profiling were completed.  Direct injection mass spectrometry (DIMS) is currently underway to enhance the INTERMAP metabolic profiling database. 

INTERMAP is funded primarily by the US National Heart, Lung, and Blood Institute; Chicago Health Research Foundation; project grant from the West Midlands National Health Service Research and Development and Grant No. R2019EPH from the Chest, Heart, and Stroke Association, Northern Ireland; Grant (A) from the Japanese Ministry of Education, Science, Sports and Culture; national agencies in China.

INTERMAP China Prospective (ICP) Study is funded by Wellcome Trust and National Natural Science Foundation of China, fieldwork completed in December 2016.


Recent publications

  • Chekmeneva E, Dos Santos Correia G, Chan Q, Wijeyesekera A, Tin A, Young JH, Elliott P, Nicholson JK, Holmes E. Optimization and application of direct infusion nanoelectrospray HRMS method for large-scale urinary metabolic phenotyping in molecular epidemiology. J Proteome Res. 2017 (In press)
  • Garcia-Perez I, Posma JM, Gibson R, Chambers ES, Hansen TH, Vestergaard H, Hansen T, Beckmann M, Pedersen O, Elliott P, Stamler J, Nicholson JK, Draper J, Mathers JC, Holmes E, Frost G. Objective assessment of dietary patterns by use of metabolic phenotyping: A randomised, controlled, crossover trial. Lancet Diabetes Endocrinol. 2017;5:184-195
  • Oude Griep LM, Seferidi P, Stamler J, Van Horn L, Chan Q, Tzoulaki I, Steffen LM, Miura K, Ueshima H, Okuda N, Zhao L, Soedamah-Muthu SS, Daviglus ML, Elliott P, Group IR. Relation of unprocessed, processed red meat and poultry consumption to blood pressure in East Asian and Western adults. J Hypertens. 2016;34:1721-1729
  • Okuda N, Okayama A, Miura K, Yoshita K, Saito S, Nakagawa H, Sakata K, Miyagawa N, Chan Q, Elliott P, Ueshima H, Stamler J. Food sources of dietary sodium in the Japanese adult population: The international study of macro-/micronutrients and blood pressure (INTERMAP). Eur J Nutr. 2016
  • Nakamura Y, Ueshima H, Okuda N, Miura K, Kita Y, Miyagawa N, Yoshita K, Nakagawa H, Sakata K, Saitoh S, Okamura T, Okayama A, Choudhry SR, Rodriguez B, Masaki KH, Chan Q, Elliott P, Stamler J. Relationship of three different types of low-carbohydrate diet to cardiometabolic risk factors in a Japanese population: The INTERMAP/INTERLIPID Study. Eur J Nutr. 2016;55:1515-1524
  • Chan Q, Loo RL, Ebbels TM, Van Horn L, Daviglus ML, Stamler J, Nicholson JK, Holmes E, Elliott P. Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: An overview. Hypertens Res. 2016
  • Blaise BJ, Correia G, Tin A, Young JH, Vergnaud AC, Lewis M, Pearce JT, Elliott P, Nicholson JK, Holmes E, Ebbels TM. Power analysis and sample size determination in metabolic phenotyping. Anal Chem. 2016;88:5179-5188
  • Chan Q, Stamler J, Griep LM, Daviglus ML, Horn LV, Elliott P. An update on nutrients and blood pressure. J Atheroscler Thromb. 2016;23:276-289
  • Elliott P, Posma JM, Chan Q, Garcia-Perez I, Wijeyesekera A, Bictash M, Ebbels TM, Ueshima H, Zhao L, van Horn L, Daviglus M, Stamler J, Holmes E, Nicholson JK. Urinary metabolic signatures of human adiposity. Science Translational Medicine. 2015;7:285ra262
  • Aljuraiban GS, Griep LM, Chan Q, Daviglus ML, Stamler J, Van Horn L, Elliott P, Frost GS. Total, insoluble and soluble dietary fibre intake in relation to blood pressure: The INTERMAP study. The British Journal of Nutrition. 2015;114:1480-1486