Imperial College London
Alternate

Professor Aldo R. Boccaccini

Faculty of Engineering, Department of Materials

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6731a.boccaccini

 
 
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Location

 

210Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patra:2014:10.1160/TH14-05-0480,
author = {Patra, C and Boccaccini, AR and Engel, FB},
doi = {10.1160/TH14-05-0480},
journal = {Thrombosis and Haemostasis},
pages = {532--547},
title = {Vascularisation for cardiac tissue engineering: the extracellular matrix.},
url = {http://dx.doi.org/10.1160/TH14-05-0480},
volume = {113},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiovascular diseases present a major socio-economic burden. One major problem underlying most cardiovascular and congenital heart diseases is the irreversible loss of contractile heart muscle cells, the cardiomyocytes. To reverse damage incurred by myocardial infarction or by surgical correction of cardiac malformations, the loss of cardiac tissue with a thickness of a few millimetres needs to be compensated. A promising approach to this issue is cardiac tissue engineering. In this review we focus on the problem of in vitro vascularisation as implantation of cardiac patches consisting of more than three layers of cardiomyocytes (> 100 µm thick) already results in necrosis. We explain the need for vascularisation and elaborate on the importance to include non-myocytes in order to generate functional vascularised cardiac tissue. We discuss the potential of extracellular matrix molecules in promoting vascularisation and introduce nephronectin as an example of a new promising candidate. Finally, we discuss current biomaterial-based approaches including micropatterning, electrospinning, 3D micro-manufacturing technology and porogens. Collectively, the current literature supports the notion that cardiac tissue engineering is a realistic option for future treatment of paediatric and adult patients with cardiac disease.
AU  - Patra,C
AU  - Boccaccini,AR
AU  - Engel,FB
DO  - 10.1160/TH14-05-0480
EP  - 547
PY  - 2014///
SN  - 0340-6245
SP  - 532
TI  - Vascularisation for cardiac tissue engineering: the extracellular matrix.
T2  - Thrombosis and Haemostasis
UR  - http://dx.doi.org/10.1160/TH14-05-0480
VL  - 113
ER  -
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