Imperial College London


Faculty of MedicineNational Heart & Lung Institute








GSB 311Royal BromptonRoyal Brompton Campus





Anne Burke-Gaffney is a Research Lecturer in Vascular Biology at the National Heart and Lung Institute, based at the Royal Brompton Hospital Campus, London.

A graduate of University College Dublin (BSc Pharmacology, 1988 and PhD, 1993) she secured National Asthma Campaign and subsequently British Heart Foundation funding to carry out her post-doctoral training within the NHLI. In 2002 she was awarded a Wellcome Trust University Lectureship. 

Her research concerns the cellular and molecular mechanisms of the systemic inflammatory response and vasoplegic syndromes and biomarkers for these conditions. Current focus of research includes: the role of Robo receptors and their Slit glycoprotein ligands and the involvement of the endothelial glycocalyx and associated proteins, such as syndecan-1. She is involved in multidisciplinary translational research integrating basic science and clinical studies in order to provide new insights into these syndromes.

More recently, through collaborations with clinical and non-clinical colleagues, she has also developed a research interest into the role of endothelial dysfunction in pulmonary arterial hypertension (PAH); a devastating disease that affects mostly young people, causing right heart failure and ultimately death. It is anticipated that a greater understanding of endothelial dysfunction in PAH will reveal potential novel targets for the development of drug therapies that could eventually reverse the condition.



Patel S, Burke-Gaffney A, 2019, The value of mobile tablet computers (iPads) in the undergraduate medical curriculum: an Imperial College medical student view reply, Advances in Medical Education and Practice, Vol:9, ISSN:1179-7258, Pages:769-769

Nikolakopoulou Z, Hector LR, Creagh-Brown BC, et al., 2019, Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery, Biomarkers in Medicine, Vol:13, ISSN:1752-0363, Pages:205-218

Mohiaddin H, Wong TDFK, Burke-Gaffney A, et al., 2018, Drug-coated balloon-only percutaneous coronary intervention for the treatment of De novo coronary artery disease: a systematic review, Cardiology and Therapy, Vol:7, ISSN:2193-6544, Pages:127-149


Mahomed AS, Burke-Gaffney A, Moledina S, et al., 2019, THE EFFECTS OF BMPRII LOSS ON ENDOTHELIAL SHEAR ADAPTATION IN THE PULMONARY VASCULAR ENDOTHELIUM, Winter Meeting of the British-Thoracic-Society, BMJ PUBLISHING GROUP, Pages:A61-A61, ISSN:0040-6376

Mahomed A, Burke-Gaffney A, Moledina S, et al., 2019, Late Breaking Abstract - The effects of BMPRII loss on endothelial shear adaptation in the pulmonary vascular endothelium, International Congress of the European-Respiratory-Society (ERS), EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN:0903-1936

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