Imperial College London

ProfessorAnneDell

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Carbohydrate Bichemistry
 
 
 
//

Contact

 

a.dell

 
 
//

Location

 

101BSir Ernst Chain BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Blois:2020:10.1007/s00281-020-00801-4,
author = {Blois, SM and Verlohren, S and Wu, G and Clark, G and Dell, A and Haslam, SM and Barrientos, G},
doi = {10.1007/s00281-020-00801-4},
journal = {Seminars in Immunopathology},
pages = {469--486},
title = {Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)},
url = {http://dx.doi.org/10.1007/s00281-020-00801-4},
volume = {42},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
AU - Blois,SM
AU - Verlohren,S
AU - Wu,G
AU - Clark,G
AU - Dell,A
AU - Haslam,SM
AU - Barrientos,G
DO - 10.1007/s00281-020-00801-4
EP - 486
PY - 2020///
SN - 1863-2297
SP - 469
TI - Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
T2 - Seminars in Immunopathology
UR - http://dx.doi.org/10.1007/s00281-020-00801-4
UR - https://link.springer.com/article/10.1007%2Fs00281-020-00801-4
UR - http://hdl.handle.net/10044/1/80551
VL - 42
ER -