Imperial College London
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ProfessorAdamHampshire

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 7993a.hampshire

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Winder-Rhodes:2015:10.1016/j.neurobiolaging.2014.12.006,
author = {Winder-Rhodes, SE and Hampshire, A and Rowe, JB and Peelle, JE and Robbins, TW and Owen, AM and Barker, RA},
doi = {10.1016/j.neurobiolaging.2014.12.006},
journal = {Neurobiol Aging},
pages = {1519--1528},
title = {Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals.},
url = {http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.006},
volume = {36},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Genetic variation is associated with differences in the function of the brain as well as its susceptibility to disease. The common H1 haplotypic variant of the microtubule-associated protein tau gene (MAPT) has been related to an increased risk for Parkinson's disease (PD). Furthermore, among PD patients, H1 homozygotes have an accelerated progression to dementia. We investigated the neurocognitive correlates of MAPT haplotypes using functional magnetic resonance imaging. Thirty-seven nondemented patients with PD (19 H1/H1, 18 H2 carriers) and 40 age-matched controls (21 H1/H1, 19 H2 carriers) were scanned during performance of a picture memory encoding task. Behaviorally, H1 homozygosity was associated with impaired picture recognition memory in PD patients and control subjects. These impairments in the H1 homozygotes were accompanied by an altered blood-oxygen level-dependent response in the medial temporal lobe during successful memory encoding. Additional age-related differences in blood-oxygen level-dependent response were observed in the medial temporal lobes of H1 homozygotes with PD. These results suggest that common variation in MAPT is not only associated with the dementia of PD but also differences in the neural circuitry underlying aspects of cognition in normal aging.
AU  - Winder-Rhodes,SE
AU  - Hampshire,A
AU  - Rowe,JB
AU  - Peelle,JE
AU  - Robbins,TW
AU  - Owen,AM
AU  - Barker,RA
DO  - 10.1016/j.neurobiolaging.2014.12.006
EP  - 1528
PY  - 2015///
SP  - 1519
TI  - Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals.
T2  - Neurobiol Aging
UR  - http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.006
UR  - https://www.ncbi.nlm.nih.gov/pubmed/25577413
VL  - 36
ER  -
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