Publications
276 results found
Millington KA, Fortune SM, Low J, et al., 2011, Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for <i>Mycobacterium tuberculosis</i> infection, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 5730-5735, ISSN: 0027-8424
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- Citations: 119
Pollock K, Tam H, Montamat-Sicotte D, et al., 2011, Screening for latent tuberculosis infection in HIV: should we do more?, HIV MEDICINE, Vol: 12, Pages: 42-42, ISSN: 1464-2662
Sester U, Fousse M, Dirks J, et al., 2011, Whole-Blood Flow-Cytometric Analysis of Antigen-Specific CD4 T-Cell Cytokine Profiles Distinguishes Active Tuberculosis from Non-Active States, PLOS ONE, Vol: 6, ISSN: 1932-6203
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- Citations: 96
Sridhar S, Pollock K, Lalvani A, 2011, Redefining latent tuberculosis, Future Microbiol, Vol: 6, Pages: 1021-1035, ISSN: 1746-0921
TB remains a public health problem worldwide, in part due to latent TB infection that serves as a global reservoir of potential disease. In the 20th century, the natural history of TB was defined by clinical symptoms, the tuberculin skin test and chest x-ray. The last decade witnessed the invention and application of IFN-gamma release assays and newer immunological tools that enabled a re-appraisal of the natural history of TB. Here, we review the conventional understanding of latent TB and recount how immunology has redefined latent TB as a spectrum of pathogen burden and host immune control. We discuss recent and future advances in the fields of TB immunology and diagnostics that will improve public health strategies to control TB.
Casey R, Blumenkrantz D, Millington K, et al., 2010, Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis, PLoS One, Vol: 5, ISSN: 1932-6203
BACKGROUND: IFN-gamma and IL-2 cytokine-profiles define three functional T-cell subsets which may correlate with pathogen load in chronic intracellular infections. We therefore investigated the feasibility of the immunospot platform to rapidly enumerate T-cell subsets by single-cell IFN-gamma/IL-2 cytokine-profiling and establish whether immunospot-based T-cell signatures distinguish different clinical stages of human tuberculosis infection. METHODS: We used fluorophore-labelled anti-IFN-gamma and anti-IL-2 antibodies with digital overlay of spatially-mapped colour-filtered images to enumerate dual and single cytokine-secreting M. tuberculosis antigen-specific T-cells in tuberculosis patients and in latent tuberculosis infection (LTBI). We validated results against established measures of cytokine-secreting T-cells. RESULTS: Fluorescence-immunospot correlated closely with single-cytokine enzyme-linked-immunospot for IFN-gamma-secreting T-cells and IL-2-secreting T-cells and flow-cytometry-based detection of dual IFN-gamma/IL-2-secreting T-cells. The untreated tuberculosis signature was dominated by IFN-gamma-only-secreting T-cells which shifted consistently in longitudinally-followed patients during treatment to a signature dominated by dual IFN-gamma/IL-2-secreting T-cells in treated patients. The LTBI signature differed from active tuberculosis, with higher proportions of IL-2-only and IFN-gamma/IL-2-secreting T-cells and lower proportions of IFN-gamma-only-secreting T-cells. CONCLUSIONS: Fluorescence-immunospot is a quantitative, accurate measure of functional T-cell subsets; identification of cytokine-signatures of pathogen burden, distinct clinical stages of M. tuberculosis infection and long-term immune containment suggests application for treatment monitoring and vaccine evaluation.
Millington KA, Gooding S, Hinks TSC, et al., 2010, <i>Mycobacterium tuberculosis</i>-Specific Cellular Immune Profiles Suggest Bacillary Persistence Decades after Spontaneous Cure in Untreated Tuberculosis, JOURNAL OF INFECTIOUS DISEASES, Vol: 202, Pages: 1685-1689, ISSN: 0022-1899
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- Citations: 46
Pollock K, Montamat-Sicotte D, Cooke G, et al., 2010, Exploring polyfunctional T cells in HIV and <i>Mycobacterium tuberculosis</i> co-infection; multi-colour flow for a multi-faceted problem, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 147-147, ISSN: 0019-2805
Pareek M, Watson JP, Kon OM, et al., 2010, PREVALENCE OF LATENT TUBERCULOSIS INFECTION IN IMMIGRANTS TO THE UK: FINDINGS FROM A MULTI-CENTRE STUDY, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A5-A6, ISSN: 0040-6376
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- Citations: 1
Sridhar S, Begom S, Bermingham A, et al., 2010, Cross-reactive T cells to pandemic influenza H1N1 are predominantly of an effector phenotype, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 176-176, ISSN: 0019-2805
Hingley-Wilson S, Kon OM, Hsu T, et al., 2010, <i>Mycobacterium tuberculosis</i> RD1 is a requisite for virulence-associated cellular recruitment, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 173-173, ISSN: 0019-2805
Montamat-Sicotte D, Millington K, Willcox CR, et al., 2010, Mycolic acid-specific T-cells in human tuberculosis are dynamically related to antigen load and exhibit memory expansion after cure, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 171-171, ISSN: 0019-2805
Singanayagam A, George PM, Connell DW, et al., 2010, Characterisation of tuberculous mediastinal lymphadenopathy on CT and correlation with biomarkers and chest radiograph findings., British Thoracic Society
Spavieri J, Allmendinger A, Kaiser M, et al., 2010, Antimycobacterial, Antiprotozoal and Cytotoxic Potential of Twenty-one Brown Algae (Phaeophyceae) from British and Irish Waters, PHYTOTHERAPY RESEARCH, Vol: 24, Pages: 1724-1729, ISSN: 0951-418X
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- Citations: 17
Asgheddi M, Abdullah M, ODonoghue M, et al., 2010, PREVALENCE OF VIRAL HEPATITIS IN PATIENTS UNDERGOING ANTI-TUBERCULOSIS THERAPY IN WEST LONDON, 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: WILEY-BLACKWELL, Pages: 685A-686A, ISSN: 0270-9139
Allmendinger A, Spavieri J, Kaiser M, et al., 2010, Antiprotozoal, Antimycobacterial and Cytotoxic Potential of Twenty-Three British and Irish Red Algae, PHYTOTHERAPY RESEARCH, Vol: 24, Pages: 1099-1103, ISSN: 0951-418X
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- Citations: 28
Spavieri J, Kaiser M, Casey R, et al., 2010, Antiprotozoal, Antimycobacterial and Cytotoxic Potential of Some British Green Algae, PHYTOTHERAPY RESEARCH, Vol: 24, Pages: 1095-1098, ISSN: 0951-418X
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- Citations: 67
Dodd PJ, Millington KA, Ghani AC, et al., 2010, Interpreting Tuberculin Skin Tests in a Population With a High Prevalence of HIV, Tuberculosis, and Nonspecific Tuberculin Sensitivity, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 171, Pages: 1037-1045, ISSN: 0002-9262
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- Citations: 7
Lalvani A, Pareek M, 2010, Interferon gamma release assays: principles and practice, ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, Vol: 28, Pages: 245-252, ISSN: 0213-005X
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- Citations: 109
Mutsvangwa J, Millington KA, Chaka K, et al., 2010, Identifying recent <i>Mycobacterium tuberculosis</i> transmission in the setting of high HIV and TB burden, THORAX, Vol: 65, Pages: 315-320, ISSN: 0040-6376
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- Citations: 22
Lalvani A, Pareek M, 2010, A 100 year update on diagnosis of tuberculosis infection, BRITISH MEDICAL BULLETIN, Vol: 93, Pages: 69-84, ISSN: 0007-1420
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- Citations: 88
Westwood IM, Bhakta S, Russell AJ, et al., 2010, Identification of arylamine <i>N</i>-acetyltransferase inhibitors as an approach towards novel anti-tuberculars, PROTEIN & CELL, Vol: 1, Pages: 82-95, ISSN: 1674-800X
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- Citations: 43
Lalvani A, Sridhar S, 2010, BCG vaccination: 90 years on and still so much to learn, Thorax, Vol: 65, Pages: 1036-1038, ISSN: 1468-3296
Joshi MS, Lalvani A, 2010, 'Home from home': risk perceptions, malaria and the use of chemoprophylaxis among UK South Asians, ETHNICITY & HEALTH, Vol: 15, Pages: 365-375, ISSN: 1355-7858
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- Citations: 13
Hinks TSC, Dosanjh DPS, Innes JA, et al., 2009, Frequencies of Region of Difference 1 Antigen-Specific but Not Purified Protein Derivative-Specific Gamma Interferon-Secreting T Cells Correlate with the Presence of Tuberculosis Disease but Do Not Distinguish Recent from Remote Latent Infections, INFECTION AND IMMUNITY, Vol: 77, Pages: 5486-5495, ISSN: 0019-9567
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- Citations: 28
Pareek M, White PJ, Lalvani A, et al., 2009, MODELLING THE HEALTH IMPACT AND COST-EFFECTIVENESS OF SCREENING NEW ENTRANTS TO THE UK FOR LATENT TUBERCULOSIS INFECTION, JOURNAL OF INFECTION, Vol: 59, Pages: S442-S442, ISSN: 0163-4453
Molyneaux PL, Muttardi K, Connell DW, et al., 2009, CLINICAL UTILITY OF ENDOBRONCHIAL ULTRASOUND-GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION (EBUS-TBNA) FOR THE DIAGNOSIS OF MEDIASTINAL TUBERCULOUS LYMPHADENITIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A124-A125, ISSN: 0040-6376
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- Citations: 1
Connell DW, Nathavitharana R, Jepson A, et al., 2009, PROLONGED INFECTIVITY IN URBAN UK PATIENTS WITH TB: AN UNDERAPPRECIATED PROBLEM?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A126-A126, ISSN: 0040-6376
Shora F, Cook G, Lewis J, et al., 2009, ROLE FOR 2-[FLUORINE-18]FLUORO-2-DEOXY-D-GLUCOSE (FDG) POSITRON EMISSION TOMOGRAPHY SCANNING IN ACTIVE TUBERCULOSIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A125-A125, ISSN: 0040-6376
Pareek M, Abubakar I, White PJ, et al., 2009, INCONSISTENT AND INCOHERENT METHODS OF SCREENING NEW ENTRANTS TO THE UK FOR TUBERCULOSIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A106-A107, ISSN: 0040-6376
Lalvani A, Hingley-Wilson S, 2009, Live or let die-does HIV exacerbate tuberculosis by attenuating <i>M-tuberculosis</i>-induced apoptosis?, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 86, Pages: 9-11, ISSN: 0741-5400
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- Citations: 1
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