Publications
308 results found
Miragoli M, Lab MJ, Singh A, et al., 2012, The progression towards heart failure exposes the heart to a mechano-arrhythmic response related to the cellular membrane compliance, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S46-S47, ISSN: 0008-6363
Lyon AR, Harding SE, 2012, Oxford Textbook of Heart Failure, Oxford Textbook of Heart Failure, Editors: McDonagh, Gardner, Clark, Dargie, Publisher: Oxford University Press, USA, ISBN: 9780199577729
In full colour throughout, containing over 300 illustrations, and supported by detailed referencing from the huge evidence base that has developed over the last ...
Lyon AR, Nikolaev VO, Miragoli M, et al., 2012, Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure, Circulation: Heart Failure, Vol: 5, Pages: 357-365
Kumaraswamy R, Lyon AR, Volkman I, et al., 2012, SERCA2a gene therapy restores microRNA-1 1 expression in heart failure via an AKT/FoxO3A-dependent pathway, E. Heart J., Vol: 33, Pages: 1067-1075
Lyon AR, Nikolaev VO, Miragoli M, et al., 2011, Plasticity of Surface Structures and Beta 2-adrenergic Receptor Localization in Failing Ventricular Cardiomyocytes During Recovery From Heart Failure, CIRCULATION, Vol: 124, ISSN: 0009-7322
Ng FS, Cooper SA, Chowdhury RA, et al., 2011, Short-term enhancement of gap junctional coupling during early myocardial infarction modifies late susceptibility to ventricular arrhythmias, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 797-797, ISSN: 0195-668X
Kumar S, Wilding D, Sikkel MB, et al., 2011, High-speed 2D and 3D fluorescence microscopy of cardiac myocytes, OPTICS EXPRESS, Vol: 19, Pages: 13839-13847, ISSN: 1094-4087
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- Citations: 49
Lyon AR, Bannister ML, Collins T, et al., 2011, SERCA2a Gene Transfer Decreases Sarcoplasmic Reticulum Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 4, Pages: 362-372, ISSN: 1941-3149
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- Citations: 135
Lyon AR, Thomas G, Cobb V, et al., 2011, Cardiology, Publisher: Churchill Livingstone, ISBN: 9780443068423
Miragoli M, Moshkov A, Novak P, et al., 2011, Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells, Journal of the Royal Society Interface, Vol: 8, Pages: 913-925, ISSN: 1742-5662
Cardiovascular diseases are complex pathologies that include alterations of various cell functions at the levels of intact tissue, single cells and subcellular signalling compartments. Conventional techniques to study these processes are extremely divergent and rely on a combination of individual methods, which usually provide spatially and temporally limited information on single parameters of interest. This review describes scanning ion conductance microscopy (SICM) as a novel versatile technique capable of simultaneously reporting various structural and functional parameters at nanometre resolution in living cardiovascular cells at the level of the whole tissue, single cells and at the subcellular level, to investigate the mechanisms of cardiovascular disease. SICM is a multimodal imaging technology that allows concurrent and dynamic analysis of membrane morphology and various functional parameters (cell volume, membrane potentials, cellular contraction, single ion-channel currents and some parameters of intracellular signalling) in intact living cardiovascular cells and tissues with nanometre resolution at different levels of organization (tissue, cellular and subcellular levels). Using this technique, we showed that at the tissue level, cell orientation in the inner and outer aortic arch distinguishes atheroprone and atheroprotected regions. At the cellular level, heart failure leads to a pronounced loss of T-tubules in cardiac myocytes accompanied by a reduction in Z-groove ratio. We also demonstrated the capability of SICM to measure the entire cell volume as an index of cellular hypertrophy. This method can be further combined with fluorescence to simultaneously measure cardiomyocyte contraction and intracellular calcium transients or to map subcellular localization of membrane receptors coupled to cyclic adenosine monophosphate production. The SICM pipette can be used for patch-clamp recordings of membrane potential and single channel currents. In conclusio
Kumar S, Wilding D, Sikkel MB, et al., 2011, Application of oblique plane microscopy to high speed live cell imaging, Conference on Advanced Microscopy Techniques II, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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- Citations: 1
Ng FS, Owusu-Agyei AA, Chang ETY, et al., 2010, ZP1210, a Novel Gap Junction Modulator, Attenuates Conduction Slowing and Prevents Cx43 Dephosphorylation During Metabolic Stress, American Heart Association (AHA) Scientific Sessions 2010, Pages: A13633-A13633
Lyon AR, Joudrey PJ, Jin D, et al., 2010, Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 49, Pages: 565-575, ISSN: 0022-2828
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- Citations: 45
Lyon AR, Bannister ML, Coward E, et al., 2010, STABILISATION OF SR LEAK IN HEART FAILURE AFTER SERCA2A GENE THERAPY, Annual Conference and Exhibition of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A10-A10, ISSN: 1355-6037
Jin H, Nass RD, Joudrey PJ, et al., 2010, Altered Spatiotemporal Dynamics of the Mitochondrial Membrane Potential in the Hypertrophied Heart, BIOPHYSICAL JOURNAL, Vol: 98, Pages: 2063-2071, ISSN: 0006-3495
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- Citations: 15
Chen Q-Z, Ishii H, Thouas GA, et al., 2010, An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart, BIOMATERIALS, Vol: 31, Pages: 3885-3893, ISSN: 0142-9612
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- Citations: 141
Lyon AR, Bannister ML, Kohlbrenner E, et al., 2010, Stabilisation of SR Leak in Heart Failure After SERCA2a Gene Therapy, 7th Annual Conference of the British-Society-for-Gene-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: 503-503, ISSN: 1043-0342
Nikolaev VO, Moshkov A, Lyon AR, et al., 2010, Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation., Science (New York, N.Y.), Vol: 327, Pages: 1653-7
The beta1- and beta2-adrenergic receptors (betaARs) on the surface of cardiomyocytes mediate distinct effects on cardiac function and the development of heart failure by regulating production of the second messenger cyclic adenosine monophosphate (cAMP). The spatial localization in cardiomyocytes of these betaARs, which are coupled to heterotrimeric guanine nucleotide-binding proteins (G proteins), and the functional implications of their localization have been unclear. We combined nanoscale live-cell scanning ion conductance and fluorescence resonance energy transfer microscopy techniques and found that, in cardiomyocytes from healthy adult rats and mice, spatially confined beta2AR-induced cAMP signals are localized exclusively to the deep transverse tubules, whereas functional beta1ARs are distributed across the entire cell surface. In cardiomyocytes derived from a rat model of chronic heart failure, beta2ARs were redistributed from the transverse tubules to the cell crest, which led to diffuse receptor-mediated cAMP signaling. Thus, the redistribution of beta(2)ARs in heart failure changes compartmentation of cAMP and might contribute to the failing myocardial phenotype.
Park J, Hector LR, Lyon AR, et al., 2010, Mechanical Strain At The Pulmonary Microvasculature Induces Monocyte Chemoattractant Protein-1 (MCP-1) Which Contributes To Pulmonary Inflammation And Remodelling In Chronic Heart Failure, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, ISSN: 1073-449X
Park JES, Lyon AR, Hector LR, et al., 2009, MECHANICAL STRAIN AT THE PULMONARY MICROVASCULATURE INDUCES MONOCYTE CHEMOATTRACTANT PROTEIN-1 WHICH CONTRIBUTES TO PULMONARY INFLAMMATION AND REMODELLING IN CHRONIC HEART FAILURE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A58-A58, ISSN: 0040-6376
Lyon AR, Coward E, Dubb S, et al., 2009, Stabilisation of SR Leak in Heart Failure After SERCA2a Gene Therapy, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S688-S689, ISSN: 0009-7322
Agarwal S, Lyon A, Nachev P, et al., 2009, The nervous heart: a case report and discussion of an under-recognized clinical problem, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 102, Pages: 807-809, ISSN: 1460-2725
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- Citations: 5
Lyon A, Akar FG, 2009, Active propagation of waves of mitochondrial membrane potential collapse across the intact heart, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 729-730, ISSN: 0195-668X
Lyon AR, MacLeod KT, Zhang Y, et al., 2009, Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 6854-6859, ISSN: 0027-8424
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- Citations: 279
Dunsby C, 2008, Optically sectioned imaging by oblique plane microscopy, OPTICS EXPRESS, Vol: 16, Pages: 20306-20316, ISSN: 1094-4087
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- Citations: 176
Lyon AR, Park J, Liang L, et al., 2008, Gene Transfer Of The Peripheral Type Benzodiazepine Receptor Alters The Spatio-temporal Dynamics Of The Mitochondrial Membrane Potential (ΔΨ<sub>M</sub>) Across The Intact Heart, 81st Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S528-S528, ISSN: 0009-7322
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- Citations: 3
Jin H, Chemaly ER, Lyon A, et al., 2008, Spatial Heterogeneity Of The Mitochondrial Membrane Potential Underlying Arrhythmias In Pressure Overload Hypertrophy, 81st Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S531-S531, ISSN: 0009-7322
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- Citations: 3
Jawad H, Lyon AR, Harding SE, et al., 2008, Myocardial tissue engineering, BRITISH MEDICAL BULLETIN, Vol: 87, Pages: 31-47, ISSN: 0007-1420
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- Citations: 124
Lyon AR, Harding SE, Peters NS, 2008, Cardiac Stem Cell Therapy and Arrhythmogenicity: Prometheus and the arrows of Apollo and Artemis, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 1, Pages: 207-216, ISSN: 1937-5387
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- Citations: 1
Jin H, Lyon AR, Akar FG, 2008, Arrhythmia mechanisms in the failing heart, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 31, Pages: 1048-1056, ISSN: 0147-8389
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- Citations: 39
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