Publications
308 results found
Morley-Smith AC, Omerovic E, Lyon AR, 2013, Irreversible apical ballooning may also occur, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 74, Pages: 415-415, ISSN: 1750-8460
Ng FS, Shadi IT, Peters NS, et al., 2013, Selective heart rate reduction with ivabradine slows ischaemia-induced electrophysiological changes and reduces ischaemia-reperfusion-induced ventricular arrhythmias, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 59, Pages: 67-75, ISSN: 0022-2828
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- Citations: 23
Toepfer C, Caorsi V, Kampourakis T, et al., 2013, Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 13446-13454
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- Citations: 51
Louch WE, Lyon AR, 2013, Mind the store: modulating Ca<SUP>2+</SUP> reuptake with a leaky sarcoplasmic reticulum, CARDIOVASCULAR RESEARCH, Vol: 98, Pages: 165-168, ISSN: 0008-6363
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- Citations: 2
Sikkel MB, Collins TP, Rowlands C, et al., 2013, Flecainide reduces Ca<SUP>2+</SUP> spark and wave frequency via inhibition of the sarcolemmal sodium current, CARDIOVASCULAR RESEARCH, Vol: 98, Pages: 286-296, ISSN: 0008-6363
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- Citations: 64
Gorelik J, Wright PT, Lyon AR, et al., 2013, Spatial control of the βAR system in heart failure: the transverse tubule and beyond, CARDIOVASCULAR RESEARCH, Vol: 98, Pages: 216-224, ISSN: 0008-6363
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- Citations: 36
Sikkel MB, Collins TP, Rowlands C, et al., 2013, Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply, CARDIOVASCULAR RESEARCH, Vol: 98, Pages: 327-328, ISSN: 0008-6363
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- Citations: 10
Demir OM, Darragh K, Pakrashi T, et al., 2013, Integrating the management of elevated resting heart rate in a specialist tertiary centre heart failure clinic, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S202-S202, ISSN: 1388-9842
Mills A, Harding S, Lyon A, et al., 2013, MiR-1 and SERCA2a gene therapy in the failing heart, Conference of the British-Society-for-Gene-and-Cell-Therapy (BSGCT), Publisher: MARY ANN LIEBERT INC, Pages: A34-A34, ISSN: 1043-0342
Richardson JA, Hayward C, Khanna A, et al., 2013, Predictive value of future ventricular arrhythmic risk in patients with chronic heart failure from annual remote telemonitoring, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S247-S247, ISSN: 1388-9842
Khan JM, Lyon AR, Harding SE, 2013, The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 169, Pages: 304-317, ISSN: 0007-1188
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- Citations: 53
Shah G, Scadding G, Nguyen-Lu N, et al., 2013, Peri-operative cardiac arrest with ST elevation secondary to gelofusin anaphylaxis - Kounis syndrome in the anaesthetic room, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 164, Pages: E22-E26, ISSN: 0167-5273
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- Citations: 20
Tranter MH, Wright PT, Sikkel MB, et al., 2013, Takotsubo cardiomyopathy: the pathophysiology, Heart Failure Clinics, Vol: 9, Pages: 187-196
Toepfer C, caorsi V, Kampourakis T, et al., 2013, Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease., The Journal of Biological Chemistry
Gulati A, Jabbour A, Ismail TF, et al., 2013, Association of Fibrosis With Mortality and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 309, Pages: 896-908, ISSN: 0098-7484
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- Citations: 762
Morley-Smith AC, Omerovic E, Lyon AR, 2013, Erratum: Takotsubo cardiomyopathy (British Journal of Hospital Medicine (2013) 74:2 (96)), British Journal of Hospital Medicine, Vol: 74, ISSN: 1750-8460
Morley-Smith AC, Omerovic E, Lyon AR, 2013, Takotsubo cardiomyopathy (vol 74, pg 96, 2013), BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 74, Pages: 175-175, ISSN: 1750-8460
Caorsi V, Toepfer C, Sikkel MB, et al., 2013, Non-linear optical microscopy sheds light on cardiovascular disease, PLoS ONE, Vol: 8, ISSN: 1932-6203
Many cardiac diseases have been associated with increased fibrosis and changes in the organization of fibrillar collagen. The degree of fibrosis is routinely analyzed with invasive histological and immunohistochemical methods, giving a limited and qualitative understanding of the tissue's morphological adaptation to disease. Our aim is to quantitatively evaluate the increase in fibrosis by three-dimensional imaging of the collagen network in the myocardium using the non-linear optical microscopy techniques Two-Photon Excitation microscopy (TPE) and Second Harmonic signal Generation (SHG). No sample staining is needed because numerous endogenous fluorophores are excited by a two-photon mechanism and highly non-centrosymmetric structures such as collagen generate strong second harmonic signals. We propose for the first time a 3D quantitative analysis to carefully evaluate the increased fibrosis in tissue from a rat model of heart failure post myocardial infarction. We show how to measure changes in fibrosis from the backward SHG (BSHG) alone, as only backward-propagating SHG is accessible for true in vivo applications. A 5-fold increase in collagen I fibrosis is detected in the remote surviving myocardium measured 20 weeks after infarction. The spatial distribution is also shown to change markedly, providing insight into the morphology of disease progression.
Morley-Smith AC, Lyon AR, Omerovic E, 2013, Takotsubo cardiomyopathy, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 74, Pages: 96-103, ISSN: 1750-8460
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- Citations: 2
Park JES, Lyon AR, Hector L, et al., 2012, CAN THE LUNG REVERSE REMODEL? GENE THERAPY FOR CARDIAC FAILURE ALTERS PULMONARY GENE EXPRESSION, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A20-A20, ISSN: 0040-6376
Wright PT, Diakonov I, Nikolaev VO, et al., 2012, Myocardial Gradients in Caveolar Number Modulate Cardiomyocyte Contractile Response to Specific β2AR Stimulation, CIRCULATION, Vol: 126, ISSN: 0009-7322
Bhargava A, O'Hara T, Sikkel MB, et al., 2012, Nanoscale Movement of L-Type Calcium Channels in the Cardiomyocyte Membrane Can Contribute to Arrhythmia During Heart Failure, CIRCULATION, Vol: 126, ISSN: 0009-7322
Wright PT, Nikolaev VO, Tokar S, et al., 2012, Caveolin3 Depletion Modifies β2AR-cAMP Responses at Both Cellular and Sub-Cellular Levels in Cardiomyocytes, CIRCULATION, Vol: 126, ISSN: 0009-7322
Bhattacharyya S, Roussin I, Prasad S, et al., 2012, Characterization of Cardiac Sarcoma With 2-and 3-Dimensional Echocardiography, Myocardial Contrast Echocardiography and Cardiac Magnetic Resonance Imaging, CIRCULATION, Vol: 126, Pages: E298-E300, ISSN: 0009-7322
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- Citations: 2
Debney MT, Ng FS, Lyon AR, et al., 2012, INCREASING GAP JUNCTION COUPLING WITH ROTIGAPTIDE REDUCES THE INCIDENCE OF VENTRICULAR ARRHYTHMIAS DURING REGIONAL ISCHAEMIA, Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR), Publisher: BMJ PUBLISHING GROUP, Pages: A3-A3, ISSN: 1355-6037
Paur H, Wright PT, Sikkel MB, et al., 2012, High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy., Circulation Journal, Vol: 6, Pages: 697-706
Shao Y, Redfors B, Lyon AR, et al., 2012, Trends in publications on stress-induced cardiomyopathy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 157, Pages: 435-436, ISSN: 0167-5273
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- Citations: 23
Pryse-Hawkins H, Davidson L, Fallon L, et al., 2012, AUDIT OF TERTIARY HEART FAILURE OUTPATIENT SERVICE TO ASSESS COMPLIANCE WITH UPDATED NICE GUIDELINES, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A10-A11, ISSN: 1355-6037
Roney CH, Ng FS, Chowdhury RA, et al., 2012, Hysteresis of cardiac action potential duration restitution occurs in the absence of calcium transient duration hysteresis - a dual optical mapping study of ex vivo rat hearts, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S63-S63, ISSN: 0008-6363
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- Citations: 1
Mills AM, Collins T, O'gara P, et al., 2012, Induced downregulation of miR-1 expression in cultured adult rat cardiomyocytes replicates the elevated NCX function observed in heart failure, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S68-S68, ISSN: 0008-6363
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