Imperial College London
Alternate

DrAlexanderLyon

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3409a.lyon Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rekha:2018:10.1038/s41598-018-35071-6,
author = {Rekha, B and Velmurugan, G and Freddy, AJ and Anusha, S and Ramprasath, T and Karthik, KV and Suresh, S and Kulshrestha, P and Mithieux, G and Lyon, AR and Selvam, GS and Ramasamy, S},
doi = {10.1038/s41598-018-35071-6},
journal = {Scientific Reports},
title = {Chronic intake of 4-Methylimidazole induces hyperinsulinemia and hypoglycaemia via pancreatic beta cell hyperplasia and glucose dyshomeostasis},
url = {http://dx.doi.org/10.1038/s41598-018-35071-6},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Caramel colours are the preferential food colouring agent globally, reaches wide age groups through eatables. Colas, a sweetened carbonated drink are most common caramel coloured beverage and its consumption is linked with diabetes, obesity, pancreatic cancer and other endocrine disorders. A major by-product produced during caramelization is 4-methylimidazole (4-MEI) that is detected in noteworthy concentrations in colas and other beverages. Previous studies revealed the neurotoxic and carcinogenic potential of 4-MEI in animals at higher doses but the effect of 4-MEI at theoretical maximum daily intake dose on glucose homeostasis is unexplored. Here, mice treated with 4-MEI (32 µg/kg bodyweight/day) for seven weeks exhibited severe hypoglycaemia and hyperinsulinemia mediated by hyperplasia of pancreatic beta cells and induces metabolic alterations. On combinatorial treatment, 4-MEI suppressed the glucogenic potential of non-artificial sweeteners and promotes lipogenesis. Furthermore, increased levels of C-peptide, LDL-cholesterol and triglycerides were observed in the humans with regular intake of 4-MEI containing beverages. In summary, 4-MEI induced pancreatic beta cell hyperplasia and leads to disruption of glucose and lipid homeostasis. This study suggests the need for further assessment and reconsideration of the wide usage of 4-MEI containing caramels as food additives.
AU  - Rekha,B
AU  - Velmurugan,G
AU  - Freddy,AJ
AU  - Anusha,S
AU  - Ramprasath,T
AU  - Karthik,KV
AU  - Suresh,S
AU  - Kulshrestha,P
AU  - Mithieux,G
AU  - Lyon,AR
AU  - Selvam,GS
AU  - Ramasamy,S
DO  - 10.1038/s41598-018-35071-6
PY  - 2018///
SN  - 2045-2322
TI  - Chronic intake of 4-Methylimidazole induces hyperinsulinemia and hypoglycaemia via pancreatic beta cell hyperplasia and glucose dyshomeostasis
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-018-35071-6
UR  - http://hdl.handle.net/10044/1/64576
VL  - 8
ER  -
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