Publications
10 results found
Otaiku AI, 2023, Religiosity and Risk of Parkinson’s Disease in England and the USA, Journal of Religion and Health, Vol: 62, Pages: 4192-4208, ISSN: 0022-4197
<jats:title>Abstract</jats:title><jats:p>Parkinson’s disease (PD) is associated with low religiosity cross-sectionally. Whether low religiosity might be associated with an increased risk for developing PD is unknown. This study investigated whether low religiosity in adulthood is associated with increased risk for developing PD. A population-based prospective cohort study was conducted. Participants from the English Longitudinal Study of Aging and the Midlife in the United States study who were free from PD at baseline (2004–2011) and completed questionnaires on self-reported religiosity, were included in a pooled analysis. Incident PD was based on self-report. Multivariable logistic regression was used to estimate odds ratios (OR) for developing PD according to baseline religiosity, with adjustment for sociodemographic characteristics, health and lifestyle factors and engagement in religious practices. Among 9,796 participants in the pooled dataset, 74 (0.8%) cases of incident PD were identified during a median follow-up of 8.1 years. In the fully adjusted model, compared with participants who considered religion very important in their lives at baseline, it was found that participants who considered religion “not at all important” in their lives had a tenfold risk of developing PD during follow-up (OR, 9.99; 95% CI 3.28–30.36). Moreover, there was a dose–response relationship between decreasing religiosity and increasing PD risk (<jats:italic>P</jats:italic> < 0.001 for trend). These associations were similar when adjusting for religious upbringing and when cases occurring within the first two years of follow-up were excluded from the analysis. The association was somewhat attenuated when religious practices were removed from the model as covariates, though it remained statistically significant (OR for “not at all important” vs. “very important”
Otaiku AI, 2023, Distressing dreams in childhood and risk of cognitive impairment or Parkinson's disease in adulthood: a national birth cohort study, eClinicalMedicine, Vol: 57, Pages: 101872-101872, ISSN: 2589-5370
Otaiku AI, 2022, Association of sleep abnormalities in older adults with risk of developing Parkinson’s disease, Sleep, Vol: 45, ISSN: 0161-8105
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Study Objectives</jats:title> <jats:p>Parkinson’s disease (PD) is associated with abnormalities of sleep macro- and microstructure as measured using polysomnography (PSG). Whether these abnormalities precede the development of PD is unknown. This study investigated the association between PSG measured sleep abnormalities in older adults and the risk of incident PD.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>A total of 2,770 men from the ancillary sleep study of the Osteoporotic Fractures in Men Study (MrOS), a population-based cohort from the United States, who were free from PD baseline and underwent overnight PSG, were included in this longitudinal analysis. Incident PD was based on a clinical diagnosis from a medical professional. Multivariable logistic regression was used to estimate odds ratios (OR) for incident PD by quartiles of PSG measures, with adjustment for sociodemographic characteristics, medical comorbidities, and lifestyle factors.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>During a median follow-up of 9.8 years, 70 (2.5%) cases of incident PD were identified. Longer total sleep time, lower rapid eye movement sleep (REM) percentage, a lower α/θ ratio during non-REM sleep and higher minimum oxygen saturations during REM sleep, were each associated with an increased risk of developing PD. Conversely, a higher awakening index was associated with a decreased risk of developing PD. The OR for the highest risk quartiles compared to the lowest risk quartiles, ranged from 2.1 to 3.7 (p’s &lt; .05). The associations remained significant w
Otaiku AI, 2022, Distressing dreams, cognitive decline, and risk of dementia: A prospective study of three population-based cohorts, eClinicalMedicine, Vol: 52, Pages: 101640-101640, ISSN: 2589-5370
Otaiku DAI, 2022, Distressing dreams and risk of Parkinson's disease: A population-based cohort study, eClinicalMedicine, Vol: 48, Pages: 101474-101474, ISSN: 2589-5370
Otaiku AI, 2022, Reply to: Correlation of Antidepressant Use and Symptom Time Period in Dream Enactment Behaviors, Movement Disorders Clinical Practice, Vol: 9, Pages: 132-133, ISSN: 2330-1619
Otaiku AI, 2021, Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease, Movement Disorders Clinical Practice, Vol: 8, Pages: 1041-1051, ISSN: 2330-1619
<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Dream content alterations in Parkinson's disease (PD) are associated with motor and cognitive dysfunction cross‐sectionally. Although recent studies suggest abnormal dream content in PD might also predict cognitive decline, the relationship between dream content and motor decline in PD remains unknown.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To investigate whether abnormal dream content in PD predicts both motor and cognitive decline.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Data were obtained from the Parkinson's Progression Markers Initiative cohort study. Patients were evaluated at baseline and at the 60‐month follow‐up, with validated clinical scales, including the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), Montreal Cognitive Assessment (MoCA), and the Movement Disorder Society–Unified Parkinson's Disease Rating Scale Part III (MDS‐UPDRS III). Patients were dichotomized using RBDSQ item 2, which inquires whether they frequently experience aggression in their dreams. Regression analyses were used to assess whether frequent aggressive dreams at baseline predicted longitudinal changes in MDS‐UPDRS III and MoCA scores as well as progression to Hoehn and Yahr stage 3 (H&Y ≥ 3) and cognitive impairment.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the patients, 58/224 (25.9%) reported frequent aggressive dreams at baseline. Aggressive dreams predicted a faster increase in MDS‐UPDRS III scores (β = 4.64;<jats:italic>P</jats:italic> = 0.007) and a faster decrease in MoCA scores (β = −1.49;<jats:italic>P</jats:italic> = 0.001). Fu
Pérez-Carbonell L, Lyons E, Gnoni V, et al., 2020, Adherence to wakefulness promoting medication in patients with narcolepsy, Sleep Medicine, Vol: 70, Pages: 50-54, ISSN: 1389-9457
Otaiku AI, 2019, Awakening Ptosis: A Clinical Review, Neuro-Ophthalmology, Vol: 43, Pages: 26-31, ISSN: 0165-8107
Otaiku AI, 2018, Did René Descartes Have Exploding Head Syndrome?, Journal of Clinical Sleep Medicine, Vol: 14, Pages: 675-678, ISSN: 1550-9389
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