Imperial College London
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ProfessorAlfriedVogler

Faculty of Natural Sciences, Department of Life Sciences (Silwood Park)

Professor of Molecular Systematics
 
 
 
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Contact

 

+44 (0)20 7942 5613a.vogler

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ge:2021:molbev/msaa334,
author = {Ge, D and Feijó, A and Wen, Z and Abramov, AV and Lu, L and Cheng, J and Pan, S and Ye, S and Xia, L and Jiang, X and Vogler, AP and Yang, Q},
doi = {molbev/msaa334},
journal = {Molecular Biology and Evolution},
pages = {1905--1923},
title = {Demographic history and genomic response to environmental changes in a rapid radiation of wild rats},
url = {http://dx.doi.org/10.1093/molbev/msaa334},
volume = {38},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - For organisms to survive and prosper in a harsh environment, particularly under rapid climate change, poses tremendous challenges. Recent studies have highlighted the continued loss of megafauna in terrestrial ecosystems and the subsequent surge of small mammals, such as rodents, bats, lagomorphs, and insectivores. However, the ecological partitioning of these animals will likely lead to large variation in their responses to environmental change. In the present study, we investigated the evolutionary history and genetic adaptations of white-bellied rats (Niviventer Marshall, 1976), which are widespread in the natural terrestrial ecosystems in Asia but also known as important zoonotic pathogen vectors and transmitters. The southeastern Qinghai-Tibet Plateau (QHTP) was inferred as the origin center of this genus, with parallel diversification in temperate and tropical niches. Demographic history analyses from mitochondrial and nuclear sequences of Niviventer demonstrated population size increases and range expansion for species in Southeast Asia, and habitat generalists elsewhere. Unexpectedly, population increases were seen in N. eha, which inhabits the highest elevation among Niviventer species. Genome scans of nuclear exons revealed that among the congeneric species, N. eha has the largest number of positively selected genes. Protein functions of these genes are mainly related to olfaction, taste and tumor suppression. Extensive genetic modification presents a major strategy in response to global changes in these alpine species.
AU  - Ge,D
AU  - Feijó,A
AU  - Wen,Z
AU  - Abramov,AV
AU  - Lu,L
AU  - Cheng,J
AU  - Pan,S
AU  - Ye,S
AU  - Xia,L
AU  - Jiang,X
AU  - Vogler,AP
AU  - Yang,Q
DO  - molbev/msaa334
EP  - 1923
PY  - 2021///
SN  - 0737-4038
SP  - 1905
TI  - Demographic history and genomic response to environmental changes in a rapid radiation of wild rats
T2  - Molecular Biology and Evolution
UR  - http://dx.doi.org/10.1093/molbev/msaa334
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33386846
UR  - http://hdl.handle.net/10044/1/86328
VL  - 38
ER  -
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