Imperial College London
Portrait Picture

ProfessorBorisLenhard

Faculty of Medicine, Institute of Clinical Sciences

Professor of Computational Biology
 
 
 
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Contact

 

+44 (0)20 7594 0911b.lenhard Website

 
 
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Assistant

 

Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318

 
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Location

 

6.12CLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Haberle:2016:10.1016/j.semcdb.2016.01.014,
author = {Haberle, V and Lenhard, B},
doi = {10.1016/j.semcdb.2016.01.014},
journal = {Seminars in Cell & Developmental Biology},
pages = {11--23},
title = {Promoter architectures and developmental gene regulation.},
url = {http://dx.doi.org/10.1016/j.semcdb.2016.01.014},
volume = {57},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Core promoters are minimal regions sufficient to direct accurate initiation of transcription and are crucial for regulation of gene expression. They are highly diverse in terms of associated core promoter motifs, underlying sequence composition and patterns of transcription initiation. Distinctive features of promoters are also seen at the chromatin level, including nucleosome positioning patterns and presence of specific histone modifications. Recent advances in identifying and characterizing promoters using next-generation sequencing-based technologies have provided the basis for their classification into functional groups and have shed light on their modes of regulation, with important implications for transcriptional regulation in development. This review discusses the methodology and the results of genome-wide studies that provided insight into the diversity of RNA polymerase II promoter architectures in vertebrates and other Metazoa, and the association of these architectures with distinct modes of regulation in embryonic development and differentiation.
AU  - Haberle,V
AU  - Lenhard,B
DO  - 10.1016/j.semcdb.2016.01.014
EP  - 23
PY  - 2016///
SN  - 1096-3634
SP  - 11
TI  - Promoter architectures and developmental gene regulation.
T2  - Seminars in Cell & Developmental Biology
UR  - http://dx.doi.org/10.1016/j.semcdb.2016.01.014
UR  - http://hdl.handle.net/10044/1/29890
VL  - 57
ER  -
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