Imperial College London
Alternate

ProfessorCarelLe Roux

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7970 719 453c.leroux

 
 
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Location

 

08, east wingCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maghsoodi:2016:10.1177/0004563216667964,
author = {Maghsoodi, N and Alaghband-Zadeh, J and Cross, G and Werling, M and Fandriks, L and Docherty, NG and Olbers, T and Dew, T and Sherwood, R and Vincent, RP and Le, Roux CW},
doi = {10.1177/0004563216667964},
journal = {Annals of Clinical Biochemistry},
title = {ANNALS EXPRESS: Elevated Fasting & Post-prandial C-Terminal Telopeptide (CTX) after Roux-en-Y gastric bypass (RYGB)},
url = {http://dx.doi.org/10.1177/0004563216667964},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Roux-en-Y gastric bypass (RYGB) increases circulating Bile Acids (BAs) concentrations, known mediators of post-prandial suppression of markers of bone resorption. Long-term data however indicate that RYGB confers an increased risk of bone loss on recipients. METHODS: Thirty six obese individuals, median age 44 (26-64) with median BMI at baseline of 42.5 (40.4 - 46) were studied before and 15 months after RYGB. After an overnight fast, patients received a 400 Kcal mixed meal. Blood samples were collected pre-meal then at 30 minute periods for 120 mins. Pre and post-meal samples were analysed for total BAs, Parathyroid Hormone (PTH) and C-terminal Telopeptide (CTX). RESULTS: Body weight loss post-RYGB was associated with a median 4.9-fold increase in peak post-prandial total BA concentration and a median 2.4-fold increase in cumulative food evoked BA response. Median fasting PTH, post-prandial reduction in PTH and total PTH release over 120 minutes remained unchanged after surgery. After surgery, median fasting CTX increased 2.3 fold, peak post-prandial levels increased 3.8 fold and total release was increased 1.9-fold CONCLUSIONS: : Fasting and postprandial total BAs and CTX are increased above normal range after RYGB. These changes occur in spite of improved Vitamin D status with supplementation. These results suggest that post-RYGB increases in total BAs do not effectively oppose an ongoing resorptive signal operative along the gut-bone axis. Serial measurement of CTX may be of value as a risk marker for long-term skeletal pathology in patients post-RYGB.
AU  - Maghsoodi,N
AU  - Alaghband-Zadeh,J
AU  - Cross,G
AU  - Werling,M
AU  - Fandriks,L
AU  - Docherty,NG
AU  - Olbers,T
AU  - Dew,T
AU  - Sherwood,R
AU  - Vincent,RP
AU  - Le,Roux CW
DO  - 10.1177/0004563216667964
PY  - 2016///
SN  - 0004-5632
TI  - ANNALS EXPRESS: Elevated Fasting & Post-prandial C-Terminal Telopeptide (CTX) after Roux-en-Y gastric bypass (RYGB)
T2  - Annals of Clinical Biochemistry
UR  - http://dx.doi.org/10.1177/0004563216667964
ER  -
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