Imperial College London
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DrClaraLopes Novo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Fellow
 
 
 
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Contact

 

c.lopes-novo

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Novo:2013:nar/gkt169,
author = {Novo, C and Arnoult, N and Bordes, W-Y and Castro-Vega, L and Gibaud, A and Dutrillaux, B and Bacchetti, S and Londono-Vallejo, A},
doi = {nar/gkt169},
journal = {Nucleic Acids Research},
pages = {4792--4801},
title = {The heterochromatic chromosome caps in great apes impact telomere metabolism},
url = {http://dx.doi.org/10.1093/nar/gkt169},
volume = {41},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In contrast with the limited sequence divergence accumulated after separation of higher primate lineages, marked cytogenetic variation has been associated with the genome evolution in these species. Studying the impact of such structural variations on defined molecular processes can provide valuable insights on how genome structural organization contributes to organismal evolution. Here, we show that telomeres on chromosome arms carrying subtelomeric heterochromatic caps in the chimpanzee, which are completely absent in humans, replicate later than telomeres on chromosome arms without caps. In gorilla, on the other hand, a proportion of the subtelomeric heterochromatic caps present in most chromosome arms are associated with large blocks of telomere-like sequences that follow a replication program different from that of bona fide telomeres. Strikingly, telomere-containing RNA accumulates extrachromosomally in gorilla mitotic cells, suggesting that at least some aspects of telomere-containing RNA biogenesis have diverged in gorilla, perhaps in concert with the evolution of heterochromatic caps in this species.
AU  - Novo,C
AU  - Arnoult,N
AU  - Bordes,W-Y
AU  - Castro-Vega,L
AU  - Gibaud,A
AU  - Dutrillaux,B
AU  - Bacchetti,S
AU  - Londono-Vallejo,A
DO  - nar/gkt169
EP  - 4801
PY  - 2013///
SN  - 0305-1048
SP  - 4792
TI  - The heterochromatic chromosome caps in great apes impact telomere metabolism
T2  - Nucleic Acids Research
UR  - http://dx.doi.org/10.1093/nar/gkt169
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318570000012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/nar/article/41/9/4792/2409080
UR  - http://hdl.handle.net/10044/1/81124
VL  - 41
ER  -
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