Imperial College London
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DrChristopherButler

Faculty of Medicine, School of Public Health

Reader in Chronic and Complex Diseases
 
 
 
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Contact

 

christopher.butler Website

 
 
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Location

 

Department of Brain SciencesSir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2021:10.3390/jpm11121318,
author = {de, Rojas I and Hernández, I and Montrreal, L and Quintela, I and Calero, M and Royo, JL and Huerto, Vilas R and González-Pérez, A and Franco-Macías, E and Macías, J and Menéndez-González, M and Frank-García, A and Diez-Fairen, M and Lage, C and García-Madrona, S and Aguilera, N and García-González, P and Puerta, R and Sotolongo-Grau, O and Alonso-Lana, S and Rábano, A and Arias, Pastor A and Pastor, AB and Corma-Gómez, A and Martín, Montes A and Martínez, Rodríguez C and Buiza-Rueda, D and Periñán, MT and Rodriguez-Rodriguez, E and Alvarez, I and Rosas, Allende I and Pineda, JA and Bernal, Sánchez-Arjona M and Fernández-Fuertes, M and Mendoza, S and Del, Ser T and Gr, AceDegesco Consortium and Garcia-Ribas, G and Sánchez-Juan, P and Pastor, P and Bullido, MJ and Álvarez, V and Real, LM and Mir, P and Piñol-Ripoll, G and García-Alberca, JM and Medina, M and Orellana, A and Butler, CR and Marquié, M and Sáez, ME and Carracedo, Á and Tárraga, L and Boada, M and Ruiz, A},
doi = {10.3390/jpm11121318},
journal = {Journal of Personalized Medicine},
pages = {1--11},
title = {Genomic characterization of host factors related to SARS-CoV-2 infection in people with dementia and control populations: The GR@ACE/DEGESCO study.},
url = {http://dx.doi.org/10.3390/jpm11121318},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
AU  - de,Rojas I
AU  - Hernández,I
AU  - Montrreal,L
AU  - Quintela,I
AU  - Calero,M
AU  - Royo,JL
AU  - Huerto,Vilas R
AU  - González-Pérez,A
AU  - Franco-Macías,E
AU  - Macías,J
AU  - Menéndez-González,M
AU  - Frank-García,A
AU  - Diez-Fairen,M
AU  - Lage,C
AU  - García-Madrona,S
AU  - Aguilera,N
AU  - García-González,P
AU  - Puerta,R
AU  - Sotolongo-Grau,O
AU  - Alonso-Lana,S
AU  - Rábano,A
AU  - Arias,Pastor A
AU  - Pastor,AB
AU  - Corma-Gómez,A
AU  - Martín,Montes A
AU  - Martínez,Rodríguez C
AU  - Buiza-Rueda,D
AU  - Periñán,MT
AU  - Rodriguez-Rodriguez,E
AU  - Alvarez,I
AU  - Rosas,Allende I
AU  - Pineda,JA
AU  - Bernal,Sánchez-Arjona M
AU  - Fernández-Fuertes,M
AU  - Mendoza,S
AU  - Del,Ser T
AU  - Gr,AceDegesco Consortium
AU  - Garcia-Ribas,G
AU  - Sánchez-Juan,P
AU  - Pastor,P
AU  - Bullido,MJ
AU  - Álvarez,V
AU  - Real,LM
AU  - Mir,P
AU  - Piñol-Ripoll,G
AU  - García-Alberca,JM
AU  - Medina,M
AU  - Orellana,A
AU  - Butler,CR
AU  - Marquié,M
AU  - Sáez,ME
AU  - Carracedo,Á
AU  - Tárraga,L
AU  - Boada,M
AU  - Ruiz,A
DO  - 10.3390/jpm11121318
EP  - 11
PY  - 2021///
SN  - 2075-4426
SP  - 1
TI  - Genomic characterization of host factors related to SARS-CoV-2 infection in people with dementia and control populations: The GR@ACE/DEGESCO study.
T2  - Journal of Personalized Medicine
UR  - http://dx.doi.org/10.3390/jpm11121318
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34945790
UR  - https://www.mdpi.com/2075-4426/11/12/1318
UR  - http://hdl.handle.net/10044/1/93362
VL  - 11
ER  -
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