Imperial College London
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DrDagfinnAune

Faculty of Medicine, School of Public Health

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 8478d.aune

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Horn:2023:10.3390/nu15051232,
author = {Horn, JW and Feng, T and Mørkedal, B and Aune, D and Strand, LB and Horn, J and Mukamal, KJ and Janszky, I},
doi = {10.3390/nu15051232},
journal = {Nutrients},
pages = {1--13},
title = {Body mass index measured repeatedly over 42 years as a risk factor for ischemic stroke: the HUNT study.},
url = {http://dx.doi.org/10.3390/nu15051232},
volume = {15},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Higher BMI in middle age is associated with ischemic stroke, but little is known about BMI over adulthood, and the risk for ischemic stroke as most studies relied on a single measurement of BMI. METHODS: BMI was measured four times over a period of 42 years. We calculated average BMI values and group-based trajectory models and related these to the prospective risk of ischemic stroke after the last examination in Cox models with a follow-up time of 12 years. RESULTS: A total of 14,139 participants, with a mean age of 65.2 years and 55.4% women, had information on BMI from all four examinations, and we observed 856 ischemic strokes. People with overweight and obesity over adulthood had a higher risk for ischemic stroke with a multivariable-adjusted hazard ratio of 1.29 (95% CI 1.11-1.48) and 1.27 (95% CI 0.96-1.67), respectively, when compared to normal weight participants. Excess weight tended to have stronger effects earlier than later in life. A trajectory of developing obesity throughout life was associated with higher risk than other trajectories. CONCLUSIONS: High average BMI, especially at an early age, is a risk factor for ischemic stroke. Early weight control and long-term weight reduction for those with high BMI may decrease the later occurrence of ischemic stroke.
AU  - Horn,JW
AU  - Feng,T
AU  - Mørkedal,B
AU  - Aune,D
AU  - Strand,LB
AU  - Horn,J
AU  - Mukamal,KJ
AU  - Janszky,I
DO  - 10.3390/nu15051232
EP  - 13
PY  - 2023///
SN  - 2072-6643
SP  - 1
TI  - Body mass index measured repeatedly over 42 years as a risk factor for ischemic stroke: the HUNT study.
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu15051232
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36904231
UR  - https://www.mdpi.com/2072-6643/15/5/1232
UR  - http://hdl.handle.net/10044/1/103243
VL  - 15
ER  -
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