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@article{Timmins:2024:10.1200/JCO.23.01101,
author = {Timmins, IR and Jones, ME and O'Brien, KM and Adami, H-O and Aune, D and Baglietto, L and Bertrand, KA and Brantley, KD and Chen, Y and Clague, DeHart J and Clendenen, TV and Dossus, L and Eliassen, AH and Fletcher, O and Fournier, A and Håkansson, N and Hankinson, SE and Houlston, RS and Joshu, CE and Kirsh, VA and Kitahara, CM and Koh, W-P and Linet, MS and Park, HL and Lynch, BM and May, AM and Mellemkjær, L and Milne, RL and Palmer, JR and Ricceri, F and Rohan, TE and Ruddy, KJ and Sánchez, M-J and Shu, X-O and Smith-Byrne, K and Steindorf, K and Sund, M and Vachon, CM and Vatten, LJ and Visvanathan, K and Weiderpass, E and Willett, WC and Wolk, A and Yuan, J-M and Zheng, W and Nichols, HB and Sandler, DP and Swerdlow, AJ and Schoemaker, MJ},
doi = {10.1200/JCO.23.01101},
journal = {J Clin Oncol},
pages = {927--939},
title = {International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts.},
url = {http://dx.doi.org/10.1200/JCO.23.01101},
volume = {42},
year = {2024}
}

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TY  - JOUR
AB  - PURPOSE: There is strong evidence that leisure-time physical activity is protective against postmenopausal breast cancer risk but the association with premenopausal breast cancer is less clear. The purpose of this study was to examine the association of physical activity with the risk of developing premenopausal breast cancer. METHODS: We pooled individual-level data on self-reported leisure-time physical activity across 19 cohort studies comprising 547,601 premenopausal women, with 10,231 incident cases of breast cancer. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% CIs for associations of leisure-time physical activity with breast cancer incidence. HRs for high versus low levels of activity were based on a comparison of risk at the 90th versus 10th percentiles of activity. We assessed the linearity of the relationship and examined subtype-specific associations and effect modification across strata of breast cancer risk factors, including adiposity. RESULTS: Over a median 11.5 years of follow-up (IQR, 8.0-16.1 years), high versus low levels of leisure-time physical activity were associated with a 6% (HR, 0.94 [95% CI, 0.89 to 0.99]) and a 10% (HR, 0.90 [95% CI, 0.85 to 0.95]) reduction in breast cancer risk, before and after adjustment for BMI, respectively. Tests of nonlinearity suggested an approximately linear relationship (Pnonlinearity = .94). The inverse association was particularly strong for human epidermal growth factor receptor 2-enriched breast cancer (HR, 0.57 [95% CI, 0.39 to 0.84]; Phet = .07). Associations did not vary significantly across strata of breast cancer risk factors, including subgroups of adiposity. CONCLUSION: This large, pooled analysis of cohort studies adds to evidence that engagement in higher levels of leisure-time physical activity may lead to reduced premenopausal breast cancer risk.
AU  - Timmins,IR
AU  - Jones,ME
AU  - O'Brien,KM
AU  - Adami,H-O
AU  - Aune,D
AU  - Baglietto,L
AU  - Bertrand,KA
AU  - Brantley,KD
AU  - Chen,Y
AU  - Clague,DeHart J
AU  - Clendenen,TV
AU  - Dossus,L
AU  - Eliassen,AH
AU  - Fletcher,O
AU  - Fournier,A
AU  - Håkansson,N
AU  - Hankinson,SE
AU  - Houlston,RS
AU  - Joshu,CE
AU  - Kirsh,VA
AU  - Kitahara,CM
AU  - Koh,W-P
AU  - Linet,MS
AU  - Park,HL
AU  - Lynch,BM
AU  - May,AM
AU  - Mellemkjær,L
AU  - Milne,RL
AU  - Palmer,JR
AU  - Ricceri,F
AU  - Rohan,TE
AU  - Ruddy,KJ
AU  - Sánchez,M-J
AU  - Shu,X-O
AU  - Smith-Byrne,K
AU  - Steindorf,K
AU  - Sund,M
AU  - Vachon,CM
AU  - Vatten,LJ
AU  - Visvanathan,K
AU  - Weiderpass,E
AU  - Willett,WC
AU  - Wolk,A
AU  - Yuan,J-M
AU  - Zheng,W
AU  - Nichols,HB
AU  - Sandler,DP
AU  - Swerdlow,AJ
AU  - Schoemaker,MJ
DO  - 10.1200/JCO.23.01101
EP  - 939
PY  - 2024///
SP  - 927
TI  - International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts.
T2  - J Clin Oncol
UR  - http://dx.doi.org/10.1200/JCO.23.01101
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38079601
VL  - 42
ER  -

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