Publications
191 results found
Andersson KE, Williams GS, Davis DM, et al., 2007, Quantifying the reduction in accessibility of the inhibitory NK cell receptor Ly49A caused by binding MHC class I proteins in cis, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 37, Pages: 516-527, ISSN: 0014-2980
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- Citations: 34
Nolte-'t Hoen ENM, Almeida CR, Cohen NR, et al., 2007, Increased surveillance of cells in mitosis by human NK cells suggests a novel strategy for limiting tumor growth and viral replication, BLOOD, Vol: 109, Pages: 670-673, ISSN: 0006-4971
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- Citations: 28
Benninger RKP, Hofmann O, Onfelt B, et al., 2007, Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 46, Pages: 2228-2231, ISSN: 1433-7851
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- Citations: 24
Onfelt B, Nedvetzki S, Benninger RKP, et al., 2006, Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 8476-8483, ISSN: 0022-1767
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- Citations: 337
Almeida CR, Davis DM, 2006, Segregation of HLA-C from ICAM-1 at NK cell immune synapses is controlled by its cell surface density, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 6904-6910, ISSN: 0022-1767
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- Citations: 56
Treanor B, Lanigan PMP, Kumar S, et al., 2006, Microclusters of inhibitory killer immunoglobulin like receptor signaling at natural killer cell immunological synapses, Journal of Cell Biology, Vol: 174, Pages: 153-161, ISSN: 1540-8140
We report the supramolecular organization of killer Ig–like receptor (KIR) phosphorylation using a technique applicable to imaging phosphorylation of any green fluorescent protein–tagged receptor at an intercellular contact or immune synapse. Specifically, we use fluorescence lifetime imaging (FLIM) to report Förster resonance energy transfer (FRET) between GFP-tagged KIR2DL1 and a Cy3-tagged generic anti-phosphotyrosine monoclonal antibody. Visualization of KIR phosphorylation in natural killer (NK) cells contacting target cells expressing cognate major histocompatibility complex class I proteins revealed that inhibitory signaling is spatially restricted to the immune synapse. This explains how NK cells respond appropriately when simultaneously surveying susceptible and resistant target cells. More surprising, phosphorylated KIR was confined to microclusters within the aggregate of KIR, contrary to an expected homogeneous distribution of KIR signaling across the immune synapse. Also, yellow fluorescent protein–tagged Lck, a kinase important for KIR phosphorylation, accumulated in a multifocal distribution at inhibitory synapses. Spatial confinement of receptor phosphorylation within the immune synapse may be critical to how activating and inhibitory signals are integrated in NK cells.
Davis DM, 2006, Intrigue at the immune synapse, SCIENTIFIC AMERICAN, Vol: 294, Pages: 48-55, ISSN: 0036-8733
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- Citations: 17
Lanigan PMP, Dunsby C, McGinty J, et al., 2006, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy
We demonstrate that spectral selection from a supercontinuum generated in a microstructured fibre can provide a continuously electronically tunable ultrafast spatially coherent source for confocal microscopy and both scanning and wide field fluorescence lifetime imaging. © 2005 Optical Society of America.
Vistulo de Abreu F, Nolte-'Hoen ENM, Almeida CR, et al., 2006, Cellular frustration: A new conceptual framework for understanding cell-mediated immune responses, 5th International Conference on Artificial Immune Systems, Publisher: SPRINGER-VERLAG BERLIN, Pages: 37-51, ISSN: 0302-9743
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- Citations: 7
Onfelt B, Purbhoo MA, Nedvetzki S, et al., 2005, Long-distance calls between cells connected by tunneling nanotubules., Sci STKE, Vol: 2005
Long membrane tethers between cells, known as membrane nantotubes or tunneling nanotubules, create supracellular structures that allow multiple cell bodies to act in a synchronized manner. Calcium fluxes, vesicles, and cell-surface components can all traffic between cells connected by nanotubes. Thus, complex and specific messages can be transmitted between multiple cells, and the strength of signal will suffer relatively little with the distance traveled, as compared to the use of soluble factors to transmit messages. Connecting multiple antigen-presenting cells, for example, can help amplify and coordinate immune responses that are distal to an antigenic site. Conversely, because the ability of a pathogen to spread between cells is a key determinant of its capacity to multiply, pathogens may exploit nanotubes for their own transmission.
Korbel DS, Newman KC, Almeida CR, et al., 2005, Heterogeneous human NK cell responses to <i>Plasmodium falciparum</i>-infected erythrocytes, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 7466-7473, ISSN: 0022-1767
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- Citations: 84
Carlin LM, Yanagi K, Verhoef A, et al., 2005, Secretion of IFN-γ and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse, BLOOD, Vol: 106, Pages: 3874-3879, ISSN: 0006-4971
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- Citations: 22
Benninger RKP, McGinty J, Hofmann O, et al., 2005, Application of multi-dimensional fluorescence imaging to microfluidic devices, European Conference on Lasers and Electro-Optics
Wang H, McCann FE, Gordan JD, et al., 2005, Erratum: (The Journal of Experimental Medicine (October 18, 2004) 200:8 (1063-1074)), Journal of Experimental Medicine, Vol: 201, ISSN: 0022-1007
Dunsby C, Lanigan PMP, McGinty J, et al., 2005, An electronically tunable ultrafast laser source applied to fluorescence imaging and microscopy including fluorescence lifetime imaging
Lanigan PMP, Dunsby C, McGinty J, et al., 2005, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy, Pages: 1366-1368
We demonstrate that spectral selection from a supercontinuum generated in a microstructured fibre can provide a continuously electronically tunable ultrafast spatially coherent source for confocal microscopy and both scanning and wide field fluorescence lifetime imaging. © 2005 Optical Society of America.
Önfelt B, Benninger RKP, Nedvetzki S, et al., 2005, Probing intercellular communication across membrane nanotubes and immunological Synapses, 49th Annual Meeting of the Biopysical-Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 431A-431A, ISSN: 0006-3495
Benninger RKP, Onfelt B, Neil MAA, et al., 2005, Imaging lipid structure with fluorescence-detected 2-photon linear dichroism, 49th Annual Meeting of the Biopysical-Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 69A-69A, ISSN: 0006-3495
Treanor B, Lanigan PMP, Suhling K, et al., 2005, Imaging fluorescence lifetime heterogeneity applied to GFP-tagged MHC protein at an immunological synapse, JOURNAL OF MICROSCOPY-OXFORD, Vol: 217, Pages: 36-43, ISSN: 0022-2720
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- Citations: 53
Benninger RKP, Önfelt B, Neil MAA, et al., 2005, Fluorescence imaging of two-photon linear dichroism:: Cholesterol depletion disrupts molecular orientation in cell membranes, BIOPHYSICAL JOURNAL, Vol: 88, Pages: 609-622, ISSN: 0006-3495
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- Citations: 62
Dunsby C, Lanigan PMP, McGinty J, et al., 2004, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy, JOURNAL OF PHYSICS D-APPLIED PHYSICS, Vol: 37, Pages: 3296-3303, ISSN: 0022-3727
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- Citations: 87
Vanherberghen B, Andersson K, Carlin LM, et al., 2004, Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 101, Pages: 16873-16878, ISSN: 0027-8424
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- Citations: 63
Standeven LJ, Carlin LM, Borszcz P, et al., 2004, The actin cytoskeleton controls the efficiency of killer Ig-like receptor accumulation at inhibitory NK cell immune synapses, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 5617-5625, ISSN: 0022-1767
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- Citations: 38
Önfelt B, Davis DM, 2004, Can membrane nanotubes facilitate communication between immune cells?, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 32, Pages: 676-678, ISSN: 0300-5127
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- Citations: 39
Wang HY, McCann FE, Gordan JD, et al., 2004, ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 200, Pages: 1063-1074, ISSN: 0022-1007
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- Citations: 79
Taner SB, Önfelt B, Pirinen NJ, et al., 2004, Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse, TRAFFIC, Vol: 5, Pages: 651-661, ISSN: 1398-9219
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- Citations: 30
Önfelt B, Nedvetzki S, Yanagi K, et al., 2004, Cutting edge:: Membrane nanotubes connect immune cells, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 1511-1513, ISSN: 0022-1767
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- Citations: 284
Davis DM, Dustin ML, 2004, What is the importance of the immunological synapse?, TRENDS IN IMMUNOLOGY, Vol: 25, Pages: 323-327, ISSN: 1471-4906
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- Citations: 222
Eleme K, Taner SB, Önfelt B, et al., 2004, Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 199, Pages: 1005-1010, ISSN: 0022-1007
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- Citations: 85
Suhling K, Siegel J, Lanigan PMP, et al., 2004, Time-resolved fluorescence anisotropy imaging applied to live cells, OPTICS LETTERS, Vol: 29, Pages: 584-586, ISSN: 0146-9592
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- Citations: 110
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