Imperial College London
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DrDanielaFecht

Faculty of Medicine, School of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3314d.fecht

 
 
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Location

 

1119Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hvidtfeldt:2021:10.1016/j.envres.2020.110568,
author = {Hvidtfeldt, UA and Chen, J and Andersen, ZJ and Atkinson, R and Bauwelinck, M and Bellander, T and Brandt, J and Brunekreef, B and Cesaroni, G and Concin, H and Fecht, D and Forastiere, F and van, Gils CH and Gulliver, J and Hertel, O and Hoek, G and Hoffmann, B and de, Hoogh K and Janssen, N and Jørgensen, JT and Katsouyanni, K and Jöckel, K-H and Ketzel, M and Klompmaker, JO and Lang, A and Leander, K and Liu, S and Ljungman, PLS and Magnusson, PKE and Mehta, AJ and Nagel, G and Oftedal, B and Pershagen, G and Peter, RS and Peters, A and Renzi, M and Rizzuto, D and Rodopoulou, S and Samoli, E and Schwarze, PE and Severi, G and Sigsgaard, T and Stafoggia, M and Strak, M and Vienneau, D and Weinmayr, G and Wolf, K and Raaschou-Nielsen, O},
doi = {10.1016/j.envres.2020.110568},
journal = {Environmental Research},
title = {Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort},
url = {http://dx.doi.org/10.1016/j.envres.2020.110568},
volume = {193},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: An association between long-term exposure to fine particulate matter (PM2.5) and lung cancer has been established in previous studies. PM2.5 is a complex mixture of chemical components from various sources and little is known about whether certain components contribute specifically to the associated lung cancer risk. The present study builds on recent findings from the "Effects of Low-level Air Pollution: A Study in Europe" (ELAPSE) collaboration and addresses the potential association between specific elemental components of PM2.5 and lung cancer incidence. METHODS: We pooled seven cohorts from across Europe and assigned exposure estimates for eight components of PM2.5 representing non-tail pipe emissions (copper (Cu), iron (Fe), and zinc (Zn)), long-range transport (sulfur (S)), oil burning/industry emissions (nickel (Ni), vanadium (V)), crustal material (silicon (Si)), and biomass burning (potassium (K)) to cohort participants' baseline residential address based on 100 m by 100 m grids from newly developed hybrid models combining air pollution monitoring, land use data, satellite observations, and dispersion model estimates. We applied stratified Cox proportional hazards models, adjusting for potential confounders (age, sex, calendar year, marital status, smoking, body mass index, employment status, and neighborhood-level socio-economic status). RESULTS: The pooled study population comprised 306,550 individuals with 3916 incident lung cancer events during 5,541,672 person-years of follow-up. We observed a positive association between exposure to all eight components and lung cancer incidence, with adjusted HRs of 1.10 (95% CI 1.05, 1.16) per 50 ng/m3 PM2.5 K, 1.09 (95% CI 1.02, 1.15) per 1 ng/m3 PM2.5 Ni, 1.22 (95% CI 1.11, 1.35) per 200 ng/m3 PM2.5 S, and 1.07 (95% CI 1.02, 1.12) per 200 ng/m3 PM2.5 V. Effect estimates were largely unaffected by adjustment for nitrogen dioxide (NO2). After adjust
AU  - Hvidtfeldt,UA
AU  - Chen,J
AU  - Andersen,ZJ
AU  - Atkinson,R
AU  - Bauwelinck,M
AU  - Bellander,T
AU  - Brandt,J
AU  - Brunekreef,B
AU  - Cesaroni,G
AU  - Concin,H
AU  - Fecht,D
AU  - Forastiere,F
AU  - van,Gils CH
AU  - Gulliver,J
AU  - Hertel,O
AU  - Hoek,G
AU  - Hoffmann,B
AU  - de,Hoogh K
AU  - Janssen,N
AU  - Jørgensen,JT
AU  - Katsouyanni,K
AU  - Jöckel,K-H
AU  - Ketzel,M
AU  - Klompmaker,JO
AU  - Lang,A
AU  - Leander,K
AU  - Liu,S
AU  - Ljungman,PLS
AU  - Magnusson,PKE
AU  - Mehta,AJ
AU  - Nagel,G
AU  - Oftedal,B
AU  - Pershagen,G
AU  - Peter,RS
AU  - Peters,A
AU  - Renzi,M
AU  - Rizzuto,D
AU  - Rodopoulou,S
AU  - Samoli,E
AU  - Schwarze,PE
AU  - Severi,G
AU  - Sigsgaard,T
AU  - Stafoggia,M
AU  - Strak,M
AU  - Vienneau,D
AU  - Weinmayr,G
AU  - Wolf,K
AU  - Raaschou-Nielsen,O
DO  - 10.1016/j.envres.2020.110568
PY  - 2021///
SN  - 0013-9351
TI  - Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort
T2  - Environmental Research
UR  - http://dx.doi.org/10.1016/j.envres.2020.110568
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33278469
UR  - http://hdl.handle.net/10044/1/85988
VL  - 193
ER  -
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