Imperial College London
Alternate

ProfessorDebbieJarvis

Faculty of Medicine, National Heart & Lung Institute

Professor of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 7944d.jarvis

 
 
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Assistant

 

Ms Hilary Barton +44 (0)20 7594 7942

 
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Location

 

28Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chinn:2007:10.1164/rccm.200612-1840OC,
author = {Chinn, S and Heinrich, J and Anto, JM and Janson, C and Norback, D and Olivieri, M and Svanes, C and Sunyer, J and Verlato, G and Wjst, M and Zock, JP and Burney, PG and Jarvis, DL},
doi = {10.1164/rccm.200612-1840OC},
journal = {AM J RESP CRIT CARE},
pages = {20--26},
title = {Bronchial responsiveness in atopic adults increases with Exposure to cat allergen},
url = {http://dx.doi.org/10.1164/rccm.200612-1840OC},
volume = {176},
year = {2007}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale: The association of asthma with sensitization and allergen exposure is known to be complex. There have been few studies of bronchial responsiveness in relation to both risk factors in adults.Objectives: To determine the relation of bronchial responsiveness to allergen exposure and IgE sensitization in a community study taking into account the major determinants of bronchial responsiveness in adulthood.Methods: Cross-sectional data were drawn from 1,884 participants in 20 centers in the European Community Respiratory Health Survey follow-up, which included measurement of house dust mite and cat allergen in mattress dust samples, and IgE sensitization to four allergens. Bronchial responsiveness to methacholine was expressed as a continuous variable, and analyzed by multiple regression.Measurements and Main Results: The trend toward greater bronchial responsiveness with increasing exposure to cat allergen was greater in those sensitized to any of the four allergens than those not sensitized (p = 0.001); there was no significant interaction between cat sensitization and Fel d 1 exposure. No trend was found with house dust mite allergen exposure. The difference in bronchial responsiveness between those exposed to the highest levels compared with the lowest was approximately -2.02 doubling doses of PD20 (95% confidence interval, -3.06 to -0.97), and nearly as great in those exposed to more moderate levels.Conclusions: Cat allergen exposure at moderate levels may be harmful to all atopic adults. The clinical implication is that it is insufficient to test patients with asthma for cat sensitization; all atopic individuals may benefit from reduced cat exposure.
AU  - Chinn,S
AU  - Heinrich,J
AU  - Anto,JM
AU  - Janson,C
AU  - Norback,D
AU  - Olivieri,M
AU  - Svanes,C
AU  - Sunyer,J
AU  - Verlato,G
AU  - Wjst,M
AU  - Zock,JP
AU  - Burney,PG
AU  - Jarvis,DL
DO  - 10.1164/rccm.200612-1840OC
EP  - 26
PY  - 2007///
SN  - 1073-449X
SP  - 20
TI  - Bronchial responsiveness in atopic adults increases with Exposure to cat allergen
T2  - AM J RESP CRIT CARE
UR  - http://dx.doi.org/10.1164/rccm.200612-1840OC
VL  - 176
ER  -
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