Publications
506 results found
Pinato DJ, Stebbing J, Ishizuka M, et al., 2012, A novel and validated prognostic index in hepatocellular carcinoma: The inflammation based index (IBI), Publisher: Elsevier, Pages: 1013-1020, ISSN: 1600-0641
Background & AimsOutcome prediction is uniquely different in hepatocellular carcinoma (HCC) as the progressive functional impairment of the liver impacts patient survival independently of tumour stage. As chronic inflammation is associated with the pathogenesis of HCC, we explored the prognostic impact of a panel of inflammatory based scores, including the modified Glasgow Prognostic Score (mGPS), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), in independent cohorts.MethodsInflammatory markers, Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program (CLIP) scores were studied in a training set of 112 patients with predominantly unresectable HCC (75%). Independent predictors of survival identified in multivariate analysis were validated in an independent cohort of 466 patients with an overall lower tumour burden (BCLC-A, 56%).ResultsIn both training and validation sets, mGPS and CLIP scores emerged as independent predictors of overall survival. The predictive accuracy of the combined mGPS and CLIP score (c score 0.7, 95% CI 0.6–0.8) appeared superior to that of the CLIP score alone (c score 0.6, 95% CI 0.5–0.7).ConclusionsSystemic inflammation as measured by the mGPS, independently predicts overall survival in HCC. We have validated a novel, easy to use inflammatory score that can be used to stratify individuals. These data enable formulation of a new prognostic system, the inflammation based index in HCC (IBI). Further validation of the IBI considering treatment allocation and survival is warranted in an independent patient cohort.
Stavraka C, Pinato DJ, O'Cathail SM, et al., 2012, Multivariate screening of prognostic factors identifies a novel, simple and objective marker to optimize patient selection and predict survival benefit in early phase trials., ASCO Annual Meeting 2012
Pinato DJ, Stavraka C, O'Cathail SM, et al., 2012, Inflammation based scores can optimize the selection of patients with advanced cancer considered for early phase clinical trials., ASCO Annual Meeting 2012
Omlin A, Spicer J, Sarker D, et al., 2012, A pharmacokinetic (PK) pharmacodynamics (PD) driven first-in-human study of the oral class I PI3K inhibitor CH5132799, in patients with advanced solid tumours., ASCO Annual Meeting 2012
Omlin A, Spicer J, Sarker D, et al., 2012, A pharmacokinetic (PK) pharmacodynamics (PD) driven first-in-human study of the oral class I PI3K inhibitor CH5132799, in patients with advanced solid tumours., 48th Annual Meeting of the American-Society-of-Clinical-Oncology
Stavraka C, Pinato DJ, O'Cathail SM, et al., 2012, Multivariate screening of prognostic factors identifies a novel, simple and objective marker to optimize patient selection and predict survival benefit in early phase trials., 48th Annual Meeting of the American-Society-of-Clinical-Oncology, Publisher: J Clin Oncol
Pinato DJ, Stavraka C, O'Cathail SM, et al., 2012, Inflammation based scores can optimize the selection of patients with advanced cancer considered for early phase clinical trials., 48th Annual Meeting of the American-Society-of-Clinical-Oncology
Pinato DJ, Stavraka C, O'Cathail SM, et al., 2012, Use of inflammation-based scores to optimize the selection of patients with advanced cancer considered for early-phase clinical trials, 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Pinato DJ, North BV, Sharma R, 2012, A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI), BRITISH JOURNAL OF CANCER, Vol: 106, Pages: 1439-1445, ISSN: 0007-0920
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- Citations: 303
Pinato DJ, Stebbing J, Ishizuka M, et al., 2012, A novel and validated prognostic index in hepatocellular carcinoma: the Inflammation Based Index (IBI)., EASL International Liver Meeting
Pinato DJ, Ramachandran R, Toloue Kalami Toussi S, et al., 2012, Role of the hypoxic signalling pathways in the histopathological prediction of malignancy in phaeochromocytomas and paragangliomas, British Endocrine Society annual meeting
Pinato DJ, Rossi D, Minh MT, et al., 2012, Hepatitis B virus and lymphomagenesis: Novel insights into an occult relationship, DIGESTIVE AND LIVER DISEASE, Vol: 44, Pages: 235-238, ISSN: 1590-8658
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- Citations: 4
Pinato DJ, Mauri FA, Ramakrishnan R, et al., 2012, Inflammation-Based Prognostic Indices in Malignant Pleural Mesothelioma, JOURNAL OF THORACIC ONCOLOGY, Vol: 7, Pages: 587-594, ISSN: 1556-0864
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- Citations: 115
Parvizi N, Alsafi A, Vergine M, et al., 2011, Expression of Somatostatin Receptors in Phaeochromocytoma and Paragangliomas., Multidisciplinary Endocrine Symposium 2011
Pinato DJ, Krell J, Wasan H, et al., 2011, Neoplastic infiltration of the sphenoid wing: A rare manifestation of metastatic colorectal cancer, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Vol: 7, Pages: 399-400, ISSN: 1743-7555
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- Citations: 5
Pinato DJ, Wasan HS, Maslen L, et al., 2011, A novel inflammatory-based prognostic score in hepatocellular carcinoma., ASCO Annual Meeting 2011
Background: In the management of hepatocellular cancer (HCC) several prognostic systems exist however these are inconsistent. Inflammation is associated with both pathogenesis and prognosis of HCC. We therefore explored the prognostic impact of 3 inflammation based prognostic scores; the Glasgow Prognostic Score (GPS), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), and compared their accuracy with the conventional BCLC and CLIP scores in order to identify a more adequate prognostic model for HCC. Methods: Patients had a diagnosis of HCC either on radiological or histological criteria as per American Association for the Study of the Liver guidelines. Patients with a history of inflammatory disease or infection were excluded. Clinical variables including demographic data, CBP, albumin, CRP, AFP, liver function tests, tumour stage including number and diameter of hepatic lesions, Child-Turcotte Pugh class, CLIP and BCLC scores were collected. GPS, NLR and PLR scoring systems were generated. Kaplan Meier statistics and log rank test were used to assess OS with each prognostic score. C-index was used to rank different staging systems. Results were then validated in an independent data set. Results: 112 consecutive patients presenting between 1993 and 2010 were included (mean age 62, range 20-83), Child Turcotte Pugh Class A 65%, intermediate/advanced BCLC Staging Algorithm 81%. Median overall survival 6.3 months. On univariate analysis GPS (p<0.001), NLR (p=0.006), PLR (p=0.01), CLIP (p<0.001) and BCLC score (p=0.002) were significant predictors of overall survival. Multivariate analysis: GPS (p=0.01) and CLIP scores (p=0.006) independent predictors of survival. CLIP score and GPS ranked as most informative staging systems, with a respective c-index score of 0.685 (95% CI 0.549-0.820) and 0.640 (95% CI 0.532-0.747). The predictive accuracy of the combined GPS and CLIP score was superior to that of the CLIP score alone, combined c-index score
Burlone ME, Minh MT, Pinato DJ, et al., 2011, HBV AND LYMPHOMAGENESIS: NOVEL INSIGHTS INTO AN OCCULT RELATIONSHIP, 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER, Pages: S155-S155, ISSN: 0168-8278
Sharma R, Pinato D, Wasan HS, et al., 2011, A novel inflammatory-based prognostic score in hepatocellular carcinoma, ASCO
Pirisi M, Leutner M, Pinato DJ, et al., 2010, Reliability and Reproducibility of the Edmondson Grading of Hepatocellular Carcinoma Using Paired Core Biopsy and Surgical Resection Specimens, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, Vol: 134, Pages: 1818-1822, ISSN: 0003-9985
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- Citations: 26
Fontanini E, Cussigh A, Fabris C, et al., 2010, Gender-related Distribution of the Interleukin-1β and Interleukin-1 Receptor Antagonist Gene Polymorphisms in Patients with End-stage Liver Disease, INFLAMMATION, Vol: 33, Pages: 251-258, ISSN: 0360-3997
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- Citations: 7
Pinato DJ, Fabris C, Falleti E, et al., 2009, Interleukin-6, gender and risk of Hepatocellular Carcinoma in patients with end-stage liver disease., AISF Annual Meeting, Publisher: Elsevier, Pages: 27-28
Falleti E, Fabris C, Toniutto P, et al., 2009, Interleukin-6 Polymorphisms and Gender: Relationship with the Occurrence of Hepatocellular Carcinoma in Patients with End-Stage Liver Disease, ONCOLOGY, Vol: 77, Pages: 304-313, ISSN: 0030-2414
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- Citations: 35
Pinato DJ, 2008, Angelo Vescovi, Encyclopedia of stem cell research, Editors: Svendsen, Ebert, Publisher: Sage Publications, Inc
Pinato DJ, 2008, Clinical Trials involving Stem Cells within the US: Cancer, Encyclopedia of stem cell research, Editors: Svendsen, Ebert, Publisher: Sage Publications, Inc
Pinato DJ, 2008, Italy (Italian stem cell research), Encyclopedia of stem cell research, Editors: Svendsen, Ebert, Publisher: Sage Publications, Inc
Pinato DJ, 2008, Piero Anversa, Encyclopedia of stem cell research, Editors: Svendsen, Ebert, Publisher: Sage Publications, Inc
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