Imperial College London
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DrDipenderGill

Faculty of Medicine, School of Public Health

Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)7904 843 810dipender.gill

 
 
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Location

 

School of a Public HealthMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Xie:2022:10.1001/jamainternmed.2022.3858,
author = {Xie, J and Prats-Uribe, A and Feng, Q and Wang, Y and Gill, D and Paredes, R and Prieto-Alhambra, D},
doi = {10.1001/jamainternmed.2022.3858},
journal = {JAMA Internal Medicine},
pages = {1063--1070},
title = {Clinical and genetic risk factors for acute incident venous Thromboembolism in ambulatory patients with COVID-19.},
url = {http://dx.doi.org/10.1001/jamainternmed.2022.3858},
volume = {182},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance: The risk of venous thromboembolism (VTE) in ambulatory COVID-19 is controversial. In addition, the association of vaccination with COVID-19-related VTE and relevant clinical and genetic risk factors remain to be elucidated. Objective: To quantify the association between ambulatory COVID-19 and short-term risk of VTE, study the potential protective role of vaccination, and investigate clinical and genetic risk factors for post-COVID-19 VTE. Design, Setting, and Participants: This population-based cohort study of patients with COVID-19 from UK Biobank included participants with SARS-CoV-2 infection that was confirmed by a positive polymerase chain test reaction result between March 1, 2020, and September 3, 2021, who were then propensity score matched to COVID-19-naive people during the same period. Participants with a history of VTE who used antithrombotic drugs (1 year before index dates) or tested positive in hospital were excluded. Exposures: First infection with SARS-CoV-2, age, sex, ethnicity, socioeconomic status, obesity, vaccination status, and inherited thrombophilia. Main Outcomes and Measures: The primary outcome was a composite VTE, including deep vein thrombosis or pulmonary embolism, which occurred 30 days after the infection. Hazard ratios (HRs) with 95% CIs were calculated using cause-specific Cox models. Results: In 18818 outpatients with COVID-19 (10580 women [56.2%]; mean [SD] age, 64.3 [8.0] years) and 93179 matched uninfected participants (52177 women [56.0%]; mean [SD] age, 64.3 [7.9] years), the infection was associated with an increased risk of VTE in 30 days (incidence rate of 50.99 and 2.37 per 1000 person-years for infected and uninfected people, respectively; HR, 21.42; 95% CI, 12.63-36.31). However, risk was substantially attenuated among the fully vaccinated (HR, 5.95; 95% CI, 1.82-19.5; interaction P = .02). In patients with COVID-19, older age, male sex, and obesity were independently associated with highe
AU  - Xie,J
AU  - Prats-Uribe,A
AU  - Feng,Q
AU  - Wang,Y
AU  - Gill,D
AU  - Paredes,R
AU  - Prieto-Alhambra,D
DO  - 10.1001/jamainternmed.2022.3858
EP  - 1070
PY  - 2022///
SN  - 2168-6106
SP  - 1063
TI  - Clinical and genetic risk factors for acute incident venous Thromboembolism in ambulatory patients with COVID-19.
T2  - JAMA Internal Medicine
UR  - http://dx.doi.org/10.1001/jamainternmed.2022.3858
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35980616
UR  - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2795466
UR  - http://hdl.handle.net/10044/1/99188
VL  - 182
ER  -
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